TIM18_YEAST - dbPTM
TIM18_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TIM18_YEAST
UniProt AC Q08749
Protein Name Mitochondrial import inner membrane translocase subunit TIM18
Gene Name TIM18
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 192
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex..
Protein Sequence MLLFPGLKPVLNASTVIVNPVRAVFPGLVLSTKRSFYSINRLNAENKINDIANTSKEASSSVQMFKPPEFSQFKDSYQKDYERIAKYTLIPLTMVPFYASFTGGVINPLLDASLSSIFLIYLQYGFTSCIIDYIPKEKYPRWHKLALYCLYGGSMLSLYGIYELETKNNGFVDLVKKLWNENDDHLYIFGRN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationLKPVLNASTVIVNPV
CCCCCCCCEEEECCH
23.3321126336
151PhosphorylationKLALYCLYGGSMLSL
HHHHHHHHCCHHHHH
18.8419779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TIM18_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TIM18_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TIM18_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TIM22_YEASTTIM22physical
10648604
TIM54_YEASTTIM54physical
10648604
TIM22_YEASTTIM22physical
10637294
TIM54_YEASTTIM54physical
10637294
DIC1_YEASTDIC1physical
15591051
TCPZ_YEASTCCT6genetic
14504216
ICY1_YEASTICY1genetic
14504216
PBP1_YEASTPBP1genetic
14504216
TIM22_YEASTTIM22genetic
10637294
TIP41_YEASTTIP41genetic
14504216
SSB1_YEASTSSB1genetic
14504216
TIM10_YEASTTIM10genetic
10648604
TIM9_YEASTTIM9genetic
10648604
TIM54_YEASTTIM54genetic
10637294
SIF2_YEASTSIF2genetic
17314980
SNT1_YEASTSNT1genetic
17314980
PHO23_YEASTPHO23genetic
17314980
RXT2_YEASTRXT2genetic
17314980
CDC73_YEASTCDC73genetic
17314980
SAP30_YEASTSAP30genetic
17314980
SPT8_YEASTSPT8genetic
17314980
SIN3_YEASTSIN3genetic
17314980
HOS2_YEASTHOS2genetic
17314980
MTU1_YEASTSLM3genetic
17314980
SET3_YEASTSET3genetic
17314980
LEO1_YEASTLEO1genetic
17314980
VPS71_YEASTVPS71genetic
17314980
VID22_YEASTVID22genetic
17314980
RCF1_YEASTRCF1genetic
17314980
PFD4_YEASTGIM3genetic
17314980
RMD5_YEASTRMD5genetic
17314980
UBP8_YEASTUBP8genetic
17314980
ARD1_YEASTARD1genetic
17314980
PFD1_YEASTPFD1genetic
17314980
SPT3_YEASTSPT3genetic
17314980
SDS3_YEASTSDS3genetic
17314980
DEP1_YEASTDEP1genetic
17314980
RSC8_YEASTRSC8genetic
17314980
BRE1_YEASTBRE1genetic
17314980
RXT3_YEASTRXT3genetic
17314980
PFD6_YEASTYKE2genetic
17314980
BUB3_YEASTBUB3genetic
17314980
MED5_YEASTNUT1genetic
17314980
SUS1_YEASTSUS1genetic
17314980
MED20_YEASTSRB2genetic
17314980
SWI6_YEASTSWI6genetic
17314980
MPH1_YEASTMPH1genetic
17314980
MED31_YEASTSOH1genetic
17314980
CWC26_YEASTBUD13genetic
17314980
PP4R3_YEASTPSY2genetic
17314980
AIM4_YEASTAIM4genetic
17314980
MED9_YEASTCSE2genetic
17314980
RAD50_YEASTRAD50genetic
17314980
MUB1_YEASTMUB1genetic
17314980
MCK1_YEASTMCK1genetic
17314980
T2EB_YEASTTFA2genetic
17314980
VPS72_YEASTVPS72genetic
17314980
DOT6_YEASTDOT6genetic
17314980
YML9_YEASTYML119Wgenetic
17314980
LSM6_YEASTLSM6genetic
17314980
PUS3_YEASTDEG1genetic
17314980
TIM22_YEASTTIM22physical
17113393
TIM54_YEASTTIM54physical
17113393
TIM10_YEASTTIM10physical
17882259
TCPZ_YEASTCCT6genetic
17893242
IRC20_YEASTIRC20genetic
19547744
TIM22_YEASTTIM22physical
18458057
SWC3_YEASTSWC3genetic
21987634
LONM_YEASTPIM1genetic
21987634
URA7_YEASTURA7genetic
21987634
MRX3_YEASTYBL095Wgenetic
21987634
FAT1_YEASTFAT1genetic
21987634
UBC4_YEASTUBC4genetic
21987634
FZO1_YEASTFZO1genetic
21987634
SWC5_YEASTSWC5genetic
21987634
PAT1_YEASTPAT1genetic
21987634
COX9_YEASTCOX9genetic
21987634
CBS1_YEASTCBS1genetic
21987634
BRE1_YEASTBRE1genetic
21987634
S2538_YEASTYDL119Cgenetic
21987634
YD157_YEASTYDL157Cgenetic
21987634
RRG1_YEASTRRG1genetic
21987634
DOP1_YEASTDOP1genetic
21987634
SEC1_YEASTSEC1genetic
21987634
SSD1_YEASTSSD1genetic
21987634
OMS1_YEASTOMS1genetic
21987634
SWA2_YEASTSWA2genetic
21987634
SWR1_YEASTSWR1genetic
21987634
UGO1_YEASTUGO1genetic
21987634
VPS72_YEASTVPS72genetic
21987634
MZM1_YEASTMZM1genetic
21987634
UCRI_YEASTRIP1genetic
21987634
AFG3_YEASTAFG3genetic
21987634
ISC1_YEASTISC1genetic
21987634
ICP55_YEASTICP55genetic
21987634
UBP3_YEASTUBP3genetic
21987634
FMP10_YEASTFMP10genetic
21987634
MDJ1_YEASTMDJ1genetic
21987634
RPOM_YEASTRPO41genetic
21987634
PSB7_YEASTPRE4genetic
21987634
SHY1_YEASTSHY1genetic
21987634
PHB1_YEASTPHB1genetic
21987634
CBP4_YEASTCBP4genetic
21987634
PET54_YEASTPET54genetic
21987634
PHB2_YEASTPHB2genetic
21987634
COX6_YEASTCOX6genetic
21987634
GEP4_YEASTGEP4genetic
21987634
PTH_YEASTPTH1genetic
21987634
MDM31_YEASTMDM31genetic
21987634
FMC1_YEASTFMC1genetic
21987634
MRS1_YEASTMRS1genetic
21987634
PT130_YEASTPET130genetic
21987634
LSM1_YEASTLSM1genetic
21987634
PBS2_YEASTPBS2genetic
21987634
RPA34_YEASTRPA34genetic
21987634
ATP12_YEASTATP12genetic
21987634
CYC1_YEASTCYC1genetic
21987634
PTK2_YEASTPTK2genetic
21987634
MG101_YEASTMGM101genetic
21987634
RS4A_YEASTRPS4Agenetic
21987634
RS4B_YEASTRPS4Agenetic
21987634
MAOM_YEASTMAE1genetic
21987634
MDM35_YEASTMDM35genetic
21987634
PMIP_YEASTOCT1genetic
21987634
CTK1_YEASTCTK1genetic
21987634
CBT1_YEASTCBT1genetic
21987634
SET3_YEASTSET3genetic
21987634
RL40A_YEASTRPL40Bgenetic
21987634
RL40B_YEASTRPL40Bgenetic
21987634
IZH3_YEASTIZH3genetic
21987634
SPT8_YEASTSPT8genetic
21987634
GEP5_YEASTGEP5genetic
21987634
UPS1_YEASTUPS1genetic
21987634
MSS51_YEASTMSS51genetic
21987634
ARV1_YEASTARV1genetic
21987634
RS28B_YEASTRPS28Bgenetic
21987634
ACON_YEASTACO1genetic
21987634
COX8_YEASTCOX8genetic
21987634
ERG6_YEASTERG6genetic
21987634
RCF1_YEASTRCF1genetic
21987634
VPS71_YEASTVPS71genetic
21987634
GSF2_YEASTGSF2genetic
21987634
CYK2_YEASTHOF1genetic
21987634
SAM37_YEASTSAM37genetic
21987634
ABF2_YEASTABF2genetic
21987634
YTA12_YEASTYTA12genetic
21987634
MUB1_YEASTMUB1genetic
21987634
AIM36_YEASTAIM36genetic
21987634
SAP30_YEASTSAP30genetic
21987634
IPYR2_YEASTPPA2genetic
21987634
GATA_YEASTHER2genetic
21987634
PHO23_YEASTPHO23genetic
21987634
TOM70_YEASTTOM70genetic
21987634
EAF7_YEASTEAF7genetic
21987634
PSD1_YEASTPSD1genetic
21987634
JJJ1_YEASTJJJ1genetic
21987634
VPS27_YEASTVPS27genetic
21987634
RCF2_YEASTRCF2genetic
21987634
BRE5_YEASTBRE5genetic
21987634
COQ10_YEASTCOQ10genetic
21987634
MDM12_YEASTMDM12genetic
21987634
H2AZ_YEASTHTZ1genetic
21987634
IF2M_YEASTIFM1genetic
21987634
MDM38_YEASTMDM38genetic
21987634
CYC2_YEASTCYC2genetic
21987634
MDM32_YEASTMDM32genetic
21987634
GEP3_YEASTGEP3genetic
21987634
MGM1_YEASTMGM1genetic
21987634
AIM41_YEASTAIM41genetic
21987634
ISU2_YEASTISU2genetic
21987634
HER1_YEASTHER1genetic
21987634
MSC6_YEASTMSC6genetic
21987634
PDE2_YEASTPDE2genetic
21987634
ALDH6_YEASTALD6genetic
21987634
MGR2_YEASTMGR2genetic
21987634
FMP30_YEASTFMP30genetic
21987634
WDR6_YEASTRTT10genetic
21987634
FUMH_YEASTFUM1genetic
21987634
YME1_YEASTYME1genetic
21987634
SYFM_YEASTMSF1genetic
21987634
MED1_YEASTMED1genetic
21987634
SDH3_YEASTSDH3physical
22152483
TIM54_YEASTTIM54physical
22152483
TIM22_YEASTTIM22physical
22152483
TIM12_YEASTTIM12physical
22152483
TIM10_YEASTTIM10physical
22152483
TIM9_YEASTTIM9physical
22152483
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
TIM22_YEASTTIM22physical
23283984
TIM54_YEASTTIM54physical
23283984
TIM22_YEASTTIM22physical
24385427
TIM54_YEASTTIM54physical
24385427
ATC3_YEASTDRS2genetic
27708008
SWD1_YEASTSWD1genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
PER1_YEASTPER1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
FMP16_YEASTFMP16genetic
27708008
APT2_YEASTAPT2genetic
27708008
GET2_YEASTGET2genetic
27708008
MNT2_YEASTMNT2genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
PEP8_YEASTPEP8genetic
27708008
YJK7_YEASTYJL107Cgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
VPS24_YEASTVPS24genetic
27708008
COXM1_YEASTCMC1genetic
27708008
RS27A_YEASTRPS27Agenetic
27708008
ERG3_YEASTERG3genetic
27708008
ALAM_YEASTALT1genetic
27708008
COA4_YEASTCOA4genetic
27708008
ERG6_YEASTERG6genetic
27708008
FAP1_YEASTFAP1genetic
27708008
ODP2_YEASTLAT1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
SWC3_YEASTSWC3genetic
27708008
GEM1_YEASTGEM1genetic
27708008
URA7_YEASTURA7genetic
27708008
ALG3_YEASTALG3genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
TTL_YEASTPBY1genetic
27708008
RXT2_YEASTRXT2genetic
27708008
YB69_YEASTYBR219Cgenetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
RIM1_YEASTRIM1genetic
27708008
SNT1_YEASTSNT1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
TGL2_YEASTTGL2genetic
27708008
RM01_YEASTMRPL1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
MCM21_YEASTMCM21genetic
27708008
SWR1_YEASTSWR1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
CEM1_YEASTCEM1genetic
27708008
RTR1_YEASTRTR1genetic
27708008
PEA2_YEASTPEA2genetic
27708008
QCR6_YEASTQCR6genetic
27708008
PALF_YEASTRIM8genetic
27708008
AAKG_YEASTSNF4genetic
27708008
HOS2_YEASTHOS2genetic
27708008
MDM34_YEASTMDM34genetic
27708008
PEX31_YEASTPEX31genetic
27708008
PHB1_YEASTPHB1genetic
27708008
QCR9_YEASTQCR9genetic
27708008
PHB2_YEASTPHB2genetic
27708008
MPC3_YEASTMPC3genetic
27708008
AP3B_YEASTAPL6genetic
27708008
TBP7_YEASTYTA7genetic
27708008
YHB7_YEASTYHL017Wgenetic
27708008
OPI1_YEASTOPI1genetic
27708008
DSE2_YEASTDSE2genetic
27708008
MNL1_YEASTMNL1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
HOS4_YEASTHOS4genetic
27708008
VTC4_YEASTVTC4genetic
27708008
NCA3_YEASTNCA3genetic
27708008
YJ09_YEASTYJR039Wgenetic
27708008
IME1_YEASTIME1genetic
27708008
YJ66_YEASTYJR096Wgenetic
27708008
MET7_YEASTSTR2genetic
27708008
DHOM_YEASTHOM6genetic
27708008
FABG_YEASTOAR1genetic
27708008
CYT2_YEASTCYT2genetic
27708008
AVT3_YEASTAVT3genetic
27708008
ELF1_YEASTELF1genetic
27708008
RM49_YEASTMRP49genetic
27708008
ASH1_YEASTASH1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
FRE2_YEASTFRE2genetic
27708008
SA190_YEASTSAP190genetic
27708008
SET3_YEASTSET3genetic
27708008
RHO4_YEASTRHO4genetic
27708008
PAM17_YEASTPAM17genetic
27708008
SPA2_YEASTSPA2genetic
27708008
HS104_YEASTHSP104genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
IZH3_YEASTIZH3genetic
27708008
COX12_YEASTCOX12genetic
27708008
ARP6_YEASTARP6genetic
27708008
UPS2_YEASTUPS2genetic
27708008
ATG26_YEASTATG26genetic
27708008
UPS1_YEASTUPS1genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
IMH1_YEASTIMH1genetic
27708008
VID22_YEASTVID22genetic
27708008
CTF3_YEASTCTF3genetic
27708008
CDC73_YEASTCDC73genetic
27708008
RCF1_YEASTRCF1genetic
27708008
VPS71_YEASTVPS71genetic
27708008
ITT1_YEASTITT1genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
COX7_YEASTCOX7genetic
27708008
SAP30_YEASTSAP30genetic
27708008
HRB1_YEASTHRB1genetic
27708008
PUB1_YEASTPUB1genetic
27708008
NIS1_YEASTNIS1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
RAS2_YEASTRAS2genetic
27708008
OCA1_YEASTOCA1genetic
27708008
TOM70_YEASTTOM70genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
PFA4_YEASTPFA4genetic
27708008
SIN3_YEASTSIN3genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
AIM39_YEASTAIM39genetic
27708008
MSB4_YEASTMSB4genetic
27708008
RTC1_YEASTRTC1genetic
27708008
TIR2_YEASTTIR2genetic
27708008
PT127_YEASTPET127genetic
27708008
CYC2_YEASTCYC2genetic
27708008
STD1_YEASTSTD1genetic
27708008
WHI5_YEASTWHI5genetic
27708008
ARF3_YEASTARF3genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
MGR2_YEASTMGR2genetic
27708008
FMP30_YEASTFMP30genetic
27708008
ATG5_YEASTATG5genetic
27708008
COX10_YEASTCOX10genetic
27708008
CTI6_YEASTCTI6genetic
27708008
RTC6_YEASTRTC6genetic
27708008
MRN1_YEASTMRN1genetic
27708008
ATG41_YEASTICY2genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
NHP6A_YEASTNHP6Agenetic
27708008
MRL1_YEASTMRL1genetic
27708008
QCR2_YEASTQCR2genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TIM18_YEAST

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