| UniProt ID | MSS51_YEAST | |
|---|---|---|
| UniProt AC | P32335 | |
| Protein Name | Protein MSS51, mitochondrial | |
| Gene Name | MSS51 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 436 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . |
|
| Protein Description | Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregation. When bound to COX1, MSS51 is unable to interact with the COX1 mRNA and translation is halted. This may be a feedback control that ensures that COX1 is only produced as long as potentially harmful assembly intermediates are not accumulating.. | |
| Protein Sequence | MTVLYAPSGATQLYFHLLRKSPHNRLVVSHQTRRHLMGFVRNALGLDPPPSPEDPTPENRFHPWDQSPSVDLRERAAKIRTLAHCPVTGKDINYTCPLSGIPTHHSREAWEMDKAYHDSKKYEILKKVNIYEHDLRSGRPFPEFDFPQQQGYDKAVNLTNWDLFFYTRSFYSMDTEFQLAAVTKMLSYPITIGSLLHKFSPYSLNPKGPITLEGLKSLAALRYTLYPLENRSLPTTTKNRAMRIFILGARAEAQLPGHVWKQLQFLFPEQSFEIHFIGPECLYKRDKQEYVKSTTPVVQRVDETLKFIYRTNFFEVFHEAQDFFPYDPYMDVFFTFHPGYASPESHGSWMGETMKALLETKCAIFTTGFNKKDLTDDINLVKSKYGKEMDVLMEPVRNVFGSTKWELNDMNPQEVYQFNMYIAGFRGKRYHTIKRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTVLYAPSG ------CEEEECCCC | 21.15 | 28889911 | |
| 5 | Phosphorylation | ---MTVLYAPSGATQ ---CEEEECCCCHHH | 16.48 | 28889911 | |
| 8 | Phosphorylation | MTVLYAPSGATQLYF CEEEECCCCHHHHHH | 32.65 | 28889911 | |
| 11 | Phosphorylation | LYAPSGATQLYFHLL EECCCCHHHHHHHHH | 23.72 | 28889911 | |
| 14 | Phosphorylation | PSGATQLYFHLLRKS CCCHHHHHHHHHHCC | 4.52 | 28889911 | |
| 51 | Phosphorylation | LGLDPPPSPEDPTPE CCCCCCCCCCCCCCC | 46.85 | 23749301 | |
| 106 | Phosphorylation | SGIPTHHSREAWEMD CCCCCCCCHHHHHHH | 24.98 | 30377154 | |
| 216 | Acetylation | PITLEGLKSLAALRY CCCHHHHHHHHHHHE | 55.04 | 24489116 | |
| 216 | Ubiquitination | PITLEGLKSLAALRY CCCHHHHHHHHHHHE | 55.04 | 23749301 | |
| 306 | Acetylation | QRVDETLKFIYRTNF HHHHHHHHHHHHCCH | 36.82 | 24489116 | |
| 382 | Acetylation | TDDINLVKSKYGKEM CCHHHHHHHHHCCCC | 44.38 | 24489116 | |
| 387 | Acetylation | LVKSKYGKEMDVLME HHHHHHCCCCCEEEH | 46.94 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MSS51_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MSS51_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MSS51_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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