GABAT_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABAT_YEAST
• UniProt AC: P17649
• Protein Name: 4-aminobutyrate aminotransferase
• Gene Name: UGA1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 471
• Subcellular Localization: Cytoplasm .
• Protein Description: Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL)..
• Protein Sequence: MSICEQYYPEEPTKPTVKTESIPGPESQKQLKELGEVFDTRPAYFLADYEKSLGNYITDVDGNTYLDLYAQISSIALGYNNPALIKAAQSPEMIRALVDRPALGNFPSKDLDKILKQILKSAPKGQDHVWSGLSGADANELAFKAAFIYYRAKQRGYDADFSEKENLSVMDNDAPGAPHLAVLSFKRAFHGRLFASGSTTCSKPIHKLDFPAFHWPHAEYPSYQYPLDENSDANRKEDDHCLAIVEELIKTWSIPVAALIIEPIQSEGGDNHASKYFLQKLRDITLKYNVVYIIDEVQTGVGATGKLWCHEYADIQPPVDLVTFSKKFQSAGYFFHDPKFIPNKPYRQFNTWCGEPARMIIAGAIGQEISDKKLTEQCSRVGDYLFKKLEGLQKKYPENFQNLRGKGRGTFIAWDLPTGEKRDLLLKKLKLNGCNVGGCAVHAVRLRPSLTFEEKHADIFIEALAKSVNEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSICEQYYP ------CCCCCCCCC	35.63	30377154
8	Phosphorylation	MSICEQYYPEEPTKP CCCCCCCCCCCCCCC	12.12	30377154
13	Phosphorylation	QYYPEEPTKPTVKTE CCCCCCCCCCCCCCC	53.59	30377154
16	Phosphorylation	PEEPTKPTVKTESIP CCCCCCCCCCCCCCC	35.87	30377154
19	Phosphorylation	PTKPTVKTESIPGPE CCCCCCCCCCCCCHH	30.54	22369663
21	Phosphorylation	KPTVKTESIPGPESQ CCCCCCCCCCCHHHH	39.04	22369663
27	Phosphorylation	ESIPGPESQKQLKEL CCCCCHHHHHHHHHH	45.90	22369663
90	Phosphorylation	ALIKAAQSPEMIRAL HHHHHHCCHHHHHHH	20.35	25752575
109	Acetylation	ALGNFPSKDLDKILK CCCCCCHHHHHHHHH	63.65	24489116
326	N6-(pyridoxal phosphate)lysine	VDLVTFSKKFQSAGY CEEEEECHHHHHCCC	54.11	-
326	Other	VDLVTFSKKFQSAGY CEEEEECHHHHHCCC	54.11	-
339	Acetylation	GYFFHDPKFIPNKPY CCCCCCCCCCCCCCC	63.08	24489116
344	Acetylation	DPKFIPNKPYRQFNT CCCCCCCCCCCCCCC	37.76	22865919
451	Phosphorylation	VRLRPSLTFEEKHAD EEECCCCCCHHHHHH	33.08	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GABAT_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABAT_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABAT_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCE_YEAST	GAD1	genetic	21371425
G3P2_YEAST	TDH2	genetic	21623372
COX7_YEAST	COX7	genetic	21623372
UGA2_YEAST	UGA2	genetic	23447388
CDC48_YEAST	CDC48	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
GPI19_YEAST	GPI19	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
RRN7_YEAST	RRN7	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
SEC12_YEAST	SEC12	genetic	27708008
CH10_YEAST	HSP10	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.
PubMed: 18407956