ATPO_YEAST - dbPTM
ATPO_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATPO_YEAST
UniProt AC P09457
Protein Name ATP synthase subunit 5, mitochondrial
Gene Name ATP5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 212
Subcellular Localization Mitochondrion. Mitochondrion inner membrane.
Protein Description Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements..
Protein Sequence MFNRVFTRSFASSLRAAASKAAAPPPVRLFGVEGTYATALYQAAAKNSSIDAAFQSLQKVESTVKKNPKLGHLLLNPALSLKDRNSVIDAIVETHKNLDGYVVNLLKVLSENNRLGCFEKIASDFGVLNDAHNGLLKGTVTSAEPLDPKSFKRIEKALSASKLVGQGKSLKLENVVKPEIKGGLIVELGDKTVDLSISTKIQKLNKVLEDSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationVFTRSFASSLRAAAS
HHHHHHHHHHHHHHH		28.0930377154
48PhosphorylationYQAAAKNSSIDAAFQ
HHHHHHCCCHHHHHH		28.1527214570
59AcetylationAAFQSLQKVESTVKK
HHHHHHHHHHHHHHH		53.9524489116
62PhosphorylationQSLQKVESTVKKNPK
HHHHHHHHHHHHCCC		41.3027214570
65SuccinylationQKVESTVKKNPKLGH
HHHHHHHHHCCCHHH		47.0923954790
65AcetylationQKVESTVKKNPKLGH
HHHHHHHHHCCCHHH		47.0924489116
66AcetylationKVESTVKKNPKLGHL
HHHHHHHHCCCHHHH		74.3124489116
69AcetylationSTVKKNPKLGHLLLN
HHHHHCCCHHHHHHC		76.2124489116
82AcetylationLNPALSLKDRNSVID
HCCCCCCCCCCHHHH		51.7924489116
86PhosphorylationLSLKDRNSVIDAIVE
CCCCCCCHHHHHHHH		22.7325371407
96AcetylationDAIVETHKNLDGYVV
HHHHHHCCCCCHHHH		67.6325381059
120AcetylationNRLGCFEKIASDFGV
CCCCHHHHHHHHHCC		24.2625381059
139PhosphorylationHNGLLKGTVTSAEPL
CCCCCCCCCCCCCCC		21.0128889911
149SuccinylationSAEPLDPKSFKRIEK
CCCCCCHHHHHHHHH		69.0923954790
149AcetylationSAEPLDPKSFKRIEK
CCCCCCHHHHHHHHH		69.0924489116
156AcetylationKSFKRIEKALSASKL
HHHHHHHHHHHHHHH		52.8624489116
161PhosphorylationIEKALSASKLVGQGK
HHHHHHHHHHHCCCC		24.1323749301
1682-HydroxyisobutyrylationSKLVGQGKSLKLENV
HHHHCCCCCEEECCC		44.73-
171AcetylationVGQGKSLKLENVVKP
HCCCCCEEECCCCCC		61.9324489116
177AcetylationLKLENVVKPEIKGGL
EEECCCCCCEEECCE		32.4224489116
192PhosphorylationIVELGDKTVDLSIST
EEEECCEEEEEEHHH		24.8022890988
196PhosphorylationGDKTVDLSISTKIQK
CCEEEEEEHHHHHHH		15.2722890988
198PhosphorylationKTVDLSISTKIQKLN
EEEEEEHHHHHHHHH		21.9222890988
199PhosphorylationTVDLSISTKIQKLNK
EEEEEHHHHHHHHHH		30.4222890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATPO_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATPO_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATPO_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATP7_YEASTATP7physical
10747812
YAJ9_YEASTYAR029Wgenetic
20093466
CHK1_YEASTCHK1genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
PSA3_YEASTPRE9genetic
20093466
ESL1_YEASTESL1genetic
20093466
HPM1_YEASTHPM1genetic
20093466
FIS1_YEASTFIS1genetic
20093466
PIR5_YEASTYJL160Cgenetic
20093466
MDHM_YEASTMDH1genetic
20093466
COX12_YEASTCOX12genetic
20093466
YL046_YEASTYLR046Cgenetic
20093466
PDC5_YEASTPDC5genetic
20093466
RL6B_YEASTRPL6Bgenetic
20093466
RCF1_YEASTRCF1genetic
20093466
ERG6_YEASTERG6genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
COX7_YEASTCOX7genetic
20093466
AEP2_YEASTAEP2genetic
20093466
APP1_YEASTAPP1genetic
20093466
TPM1_YEASTTPM1genetic
20093466
VPS27_YEASTVPS27genetic
20093466
IRA2_YEASTIRA2genetic
20093466
CY1_YEASTCYT1genetic
20093466
TGS1_YEASTTGS1genetic
20093466
RL21B_YEASTRPL21Bgenetic
20093466
CHMU_YEASTARO7genetic
20093466
ATP5E_YEASTATP15genetic
21623372
ADH3_YEASTADH3genetic
21623372
THDH_YEASTILV1genetic
21623372
ATP14_YEASTATP14genetic
21623372
ATPA_YEASTATP1genetic
21623372
ATPF_YEASTATP4genetic
21623372
QCR8_YEASTQCR8genetic
21623372
QCR9_YEASTQCR9genetic
21623372
CSG2_YEASTCSG2genetic
21623372
PYC2_YEASTPYC2genetic
21623372
PDX3_YEASTPDX3genetic
21623372
YPK9_YEASTYPK9genetic
22457822
ATPG_YEASTATP3physical
22940862
ATPA_YEASTATP1physical
22940862
ATPO_YEASTATP5physical
22940862
ATPF_YEASTATP4physical
22940862
ATPB_YEASTATP2physical
22940862
ATP7_YEASTATP7physical
22940862
CHK1_YEASTCHK1genetic
22282571
RM49_YEASTMRP49genetic
27708008
ATP10_YEASTATP10genetic
27708008
AEP2_YEASTAEP2genetic
27708008
SWS2_YEASTSWS2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
PSB6_YEASTPRE7genetic
27708008
IPYR_YEASTIPP1genetic
27708008
POP7_YEASTPOP7genetic
27708008
GLE1_YEASTGLE1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CCA1_YEASTCCA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
TIM16_YEASTPAM16genetic
27708008
DBP9_YEASTDBP9genetic
27708008
TAD3_YEASTTAD3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
TIM23_YEASTTIM23genetic
27708008
RIB2_YEASTRIB2genetic
27708008
PROF_YEASTPFY1genetic
27708008
SMP3_YEASTSMP3genetic
27708008
PRS10_YEASTRPT4genetic
27708008
MYO2_YEASTMYO2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
CSG2_YEASTCSG2genetic
27708008
ELO2_YEASTELO2genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
SLX8_YEASTSLX8genetic
27708008
MDM34_YEASTMDM34genetic
27708008
PHB2_YEASTPHB2genetic
27708008
COX23_YEASTCOX23genetic
27708008
FIS1_YEASTFIS1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
YJB6_YEASTYJL016Wgenetic
27708008
PHO86_YEASTPHO86genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
MDM35_YEASTMDM35genetic
27708008
MDHM_YEASTMDH1genetic
27708008
NU133_YEASTNUP133genetic
27708008
COX12_YEASTCOX12genetic
27708008
YL046_YEASTYLR046Cgenetic
27708008
PDC5_YEASTPDC5genetic
27708008
ERG6_YEASTERG6genetic
27708008
RCF1_YEASTRCF1genetic
27708008
CTL1_YEASTCTL1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
COX7_YEASTCOX7genetic
27708008
ODP2_YEASTLAT1genetic
27708008
APP1_YEASTAPP1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
IRA2_YEASTIRA2genetic
27708008
ROD1_YEASTROD1genetic
27708008
CY1_YEASTCYT1genetic
27708008
HUT1_YEASTHUT1genetic
27708008
CSR2_YEASTCSR2genetic
27708008
CHMU_YEASTARO7genetic
27708008
IME1_YEASTIME1genetic
29301906
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATPO_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND THR-139, AND MASSSPECTROMETRY.

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