IMH1_YEAST - dbPTM
IMH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IMH1_YEAST
UniProt AC Q06704
Protein Name Golgin IMH1
Gene Name IMH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 911
Subcellular Localization Cytoplasm. Golgi apparatus membrane
Peripheral membrane protein. IMH1 is recruited to the Golgi apparatus by ARL1.
Protein Description Involved in vesicular transport between an endosomal compartment and the Golgi apparatus..
Protein Sequence MFKQLSQIGKNLTDELAKGLADDMSPTPSEQQIEDDKSGLPKEIQAKLRKFEKYEQKYPLLLSAYKNEKLKSEKLEAVEKILAENTPISNIDDAVDTLPAFFQDLNNKNNLLNDEIKRLTKQNSEIPESASSETLKDKEEEFLKKEQNYKNDIDDLKKKMEALNIELDTVQKEKNDTVSGLREKIVALENILKEEREAKKQKEEVSISELKEELAIKNHSLEDSRMKITELEQNLSSKSTIMEEKSSELAELNITLKEKERKLSELEKKMKELPKAISHQNVGNNNRRKKNRNKGKKNKGGITTGDISEEETVDNSINTEEYDKLKENLQELQEKYKDCEDWKQKYEDIEAELKDAKELENSQLEKSAKELETLNTELIDTKKSLKEKNSELEEVRDMLRTVGNELVDAKDEIKESSSKQNEEVKTVKLELDDLRHKNATMIEAYEAKNTELRSKIELLSKKVEHLKNLCTEKEKEQTTSQNKVAKLNEEISQLTYEKSNITKELTSLRTSYKQKEKTVSYLEEQVKQFSEQKDVAEKSTEQLRKDHAKISNRLDLLKKENETLHNDIAKNSNSYEEYLKENGKLSERLNILQEKYNTLQNVKSNSNEHIDSIKRQCEELNVKLKESTKKILSLEDELNEYANIVQDKTREANTLRRLVSDSQTDDSSKQKELENKLAYLTDEKNKLEAELDLQTSRKATELQEWKHTVTELKSEIHALKLREEGLKSEVDALKHVNNDIKRKTQATSDDSDQLEQITSNLKLSLSKADEKNFELQSANEKLLNLNNELNKKFDRLLKNYRSLSSQLNALKERQYSDKSGRVSRSGSIGTLANANIDSSPANNSNPTKLEKIRSSSSLELDSEKNEKIAYIKNVLLGFLEHKEQRNQLLPVISMLLQLDSTDEKRLVMSLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MFKQLSQIGKNLT
--CHHHHHHHCHHHH		19.7721440633
13PhosphorylationSQIGKNLTDELAKGL
HHHCHHHHHHHHHHH		36.5027214570
25PhosphorylationKGLADDMSPTPSEQQ
HHHCCCCCCCCCHHH		32.3922369663
27PhosphorylationLADDMSPTPSEQQIE
HCCCCCCCCCHHHHC		31.9429136822
29PhosphorylationDDMSPTPSEQQIEDD
CCCCCCCCHHHHCCC		50.9822369663
37AcetylationEQQIEDDKSGLPKEI
HHHHCCCCCCCCHHH		59.7624489116
57AcetylationKFEKYEQKYPLLLSA
HHHHHHHHHHHHHHH		36.5724489116
124PhosphorylationKRLTKQNSEIPESAS
HHHHHCCCCCCCCCC		34.1229136822
129PhosphorylationQNSEIPESASSETLK
CCCCCCCCCCCCHHH		28.2622369663
131PhosphorylationSEIPESASSETLKDK
CCCCCCCCCCHHHHH		37.6822369663
132PhosphorylationEIPESASSETLKDKE
CCCCCCCCCHHHHHH		34.0322369663
134PhosphorylationPESASSETLKDKEEE
CCCCCCCHHHHHHHH		40.8422369663
150AcetylationLKKEQNYKNDIDDLK
HHHHHHHCCCHHHHH		56.5524489116
193AcetylationVALENILKEEREAKK
HHHHHHHHHHHHHHH		54.4524489116
257UbiquitinationAELNITLKEKERKLS
HHHCCCHHHHHHHHH		59.0819722269
264PhosphorylationKEKERKLSELEKKMK
HHHHHHHHHHHHHHH		43.0728889911
303PhosphorylationKKNKGGITTGDISEE
CCCCCCCCCCCCCHH		28.1822369663
304PhosphorylationKNKGGITTGDISEEE
CCCCCCCCCCCCHHH		30.8222369663
308PhosphorylationGITTGDISEEETVDN
CCCCCCCCHHHCCCC		43.6322369663
312PhosphorylationGDISEEETVDNSINT
CCCCHHHCCCCCCCH		36.1225521595
316PhosphorylationEEETVDNSINTEEYD
HHHCCCCCCCHHHHH		16.8622369663
319PhosphorylationTVDNSINTEEYDKLK
CCCCCCCHHHHHHHH		28.6422369663
322PhosphorylationNSINTEEYDKLKENL
CCCCHHHHHHHHHHH		16.4922369663
345AcetylationDCEDWKQKYEDIEAE
CCHHHHHHHHHHHHH		47.0524489116
366UbiquitinationLENSQLEKSAKELET
HHHHHHHHHHHHHHH		65.3923749301
373PhosphorylationKSAKELETLNTELID
HHHHHHHHHCHHHHH		37.6219795423
376PhosphorylationKELETLNTELIDTKK
HHHHHHCHHHHHHHH		34.9719795423
533UbiquitinationVKQFSEQKDVAEKST
HHHHHHHHHHHHHHH		50.5519722269
538UbiquitinationEQKDVAEKSTEQLRK
HHHHHHHHHHHHHHH		53.6019722269
545UbiquitinationKSTEQLRKDHAKISN
HHHHHHHHHHHHHHH		63.5619722269
570AcetylationTLHNDIAKNSNSYEE
HHHHHHHHCCCCHHH		62.3324489116
575PhosphorylationIAKNSNSYEEYLKEN
HHHCCCCHHHHHHHC		19.6130377154
578PhosphorylationNSNSYEEYLKENGKL
CCCCHHHHHHHCCCH		15.9030377154
584AcetylationEYLKENGKLSERLNI
HHHHHCCCHHHHHHH		61.4924489116
595AcetylationRLNILQEKYNTLQNV
HHHHHHHHHHHHHHH		30.7324489116
660PhosphorylationNTLRRLVSDSQTDDS
HHHHHHHCCCCCCCH		35.8222369663
662PhosphorylationLRRLVSDSQTDDSSK
HHHHHCCCCCCCHHH		27.7222369663
664PhosphorylationRLVSDSQTDDSSKQK
HHHCCCCCCCHHHHH		45.8122369663
713AcetylationKHTVTELKSEIHALK
HHHHHHHHHHHHHHH		39.5524489116
802PhosphorylationRLLKNYRSLSSQLNA
HHHHHHHHHHHHHHH		23.4227214570
819PhosphorylationERQYSDKSGRVSRSG
HHHCCCCCCCCCCCC		36.5021551504
823PhosphorylationSDKSGRVSRSGSIGT
CCCCCCCCCCCCHHH		21.2621440633
825PhosphorylationKSGRVSRSGSIGTLA
CCCCCCCCCCHHHHH		29.4122369663
827PhosphorylationGRVSRSGSIGTLANA
CCCCCCCCHHHHHCC		21.0622369663
830PhosphorylationSRSGSIGTLANANID
CCCCCHHHHHCCCCC		22.4922369663
838PhosphorylationLANANIDSSPANNSN
HHCCCCCCCCCCCCC		34.1322369663
839PhosphorylationANANIDSSPANNSNP
HCCCCCCCCCCCCCC		25.0422369663
844PhosphorylationDSSPANNSNPTKLEK
CCCCCCCCCCCHHHH		43.9522369663
847PhosphorylationPANNSNPTKLEKIRS
CCCCCCCCHHHHHHC		53.1422369663
854PhosphorylationTKLEKIRSSSSLELD
CHHHHHHCCCCCCCC		37.7422369663
855PhosphorylationKLEKIRSSSSLELDS
HHHHHHCCCCCCCCC		17.6925521595
856PhosphorylationLEKIRSSSSLELDSE
HHHHHCCCCCCCCCC		39.9422369663
857PhosphorylationEKIRSSSSLELDSEK
HHHHCCCCCCCCCCH		28.0122369663
862PhosphorylationSSSLELDSEKNEKIA
CCCCCCCCCHHHHHH		64.1922890988
867AcetylationLDSEKNEKIAYIKNV
CCCCHHHHHHHHHHH		41.8724489116
893PhosphorylationNQLLPVISMLLQLDS
HCHHHHHHHHHCCCC		12.0119779198
900PhosphorylationSMLLQLDSTDEKRLV
HHHHCCCCCCCHHHH		46.4819779198
901PhosphorylationMLLQLDSTDEKRLVM
HHHCCCCCCCHHHHH		48.0919779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IMH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IMH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IMH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IMH1_YEASTIMH1physical
9880327
ARL1_YEASTARL1physical
12620188
RIC1_YEASTRIC1genetic
10990452
RUD3_YEASTRUD3physical
19591838
ARL1_YEASTARL1physical
20841378
SRS2_YEASTSRS2genetic
21459050
ARL1_YEASTARL1physical
22767516
GCS1_YEASTGCS1genetic
22767516
IMH1_YEASTIMH1physical
22767516
SPC72_YEASTSPC72physical
22875988
GIN4_YEASTGIN4physical
22875988
FMP32_YEASTFMP32physical
22875988
ATG1_YEASTATG1physical
22875988
SEC9_YEASTSEC9physical
22875988
SPR3_YEASTSPR3physical
22875988
TAF1_YEASTTAF1physical
22875988
BZZ1_YEASTBZZ1physical
22875988
YKF0_YEASTYKL050Cphysical
22875988
BLI1_YEASTBLI1physical
22875988
LHS1_YEASTLHS1physical
22875988
SMY1_YEASTSMY1physical
22875988
DID2_YEASTDID2physical
22875988
BOS1_YEASTBOS1physical
22875988
MDN1_YEASTMDN1physical
22875988
END3_YEASTEND3physical
22875988
RUD3_YEASTRUD3physical
22875988
SVL3_YEASTSVL3physical
22875988
TBP6_YEASTYTA6physical
22875988
NOP53_YEASTNOP53physical
22875988
NIP80_YEASTNIP100physical
22875988
YP216_YEASTYPL216Wphysical
22875988
GYP5_YEASTGYP5physical
22875988
OLA1_YEASTOLA1genetic
27708008
AMN1_YEASTAMN1genetic
27708008
AGP2_YEASTAGP2genetic
27708008
MRC1_YEASTMRC1genetic
27708008
THRC_YEASTTHR4genetic
27708008
SRF1_YEASTSRF1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
TRS85_YEASTTRS85genetic
27708008
PMP3_YEASTPMP3genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
GIP2_YEASTGIP2genetic
27708008
GET2_YEASTGET2genetic
27708008
METE_YEASTMET6genetic
27708008
AIM11_YEASTAIM11genetic
27708008
BUD27_YEASTBUD27genetic
27708008
MIC19_YEASTMIC19genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YKE44_YEASTYKL044Wgenetic
27708008
SEG2_YEASTSEG2genetic
27708008
DCOR_YEASTSPE1genetic
27708008
IRS4_YEASTIRS4genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DBP7_YEASTDBP7genetic
27708008
VBA5_YEASTVBA5genetic
27708008
RIC1_YEASTRIC1genetic
27708008
TLG2_YEASTTLG2genetic
27708008
GYP1_YEASTGYP1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
ATC3_YEASTDRS2genetic
24706946
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IMH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-308; THR-312;SER-660; SER-825; SER-827; SER-854; SER-855; SER-856 AND SER-857, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-308; SER-825;SER-827; SER-854; SER-856 AND SER-857, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, AND MASSSPECTROMETRY.

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