TBP6_YEAST - dbPTM
TBP6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBP6_YEAST
UniProt AC P40328
Protein Name Probable 26S proteasome subunit YTA6
Gene Name YTA6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 754
Subcellular Localization
Protein Description
Protein Sequence MAHEKFSIPENFTLAQSLQLLYSVVKNQYKNLADLIINSKGNKDTVTYGKIHKNLDTLLVYVNEGLRKIEKTYTLKKGLGNLVVDHPELRSIIEDFQILGQDIRIARRKAETLMAEGNGSPSLSSSSSVLGLGTGNGLRFPKLWRMGSKRDKLKEADEKEAKINKQADNIRRARKLEEEKKLGAKLQYERDLELQREKLIELKVKEKVEFEVAQKLEEERVKREEEERKHREQAEKKRISTLKHERKTNYKSRASLDNFSSSSKSSGKIDNSLIKRRSLDVVRTSGERVRTPVRKSMEAAEIGMAAQLAWSQYQNGANHSKVSNNGSHSNELQIRYKPTPPLKKRYDYKKPTVNRPIIKSPTLNRQNSKSSRNIPTNSKLKASKSNTNKVSRRNEQNLEPSSPVLVSATAVPAESKPMRSKSGTPDKESSASSSLDSRKEDILKSVQGVDRNACEQILNEILVTDEKVYWEDIAGLRNAKNSLKEAVVYPFLRPDLFKGLREPVRGMLLFGPPGTGKTMIAKAVATESNSTFFSVSASSLLSKYLGESEKLVRALFYMAKKLSPSIIFIDEIDSMLTARSDNENESSRRIKTELLIQWSSLSSATAQSEDRNNTLDSRVLVLGATNLPWAIDDAARRRFSRKLYIPLPDYETRLYHLKRLMAKQKNSLQDLDYELITEMTEGFSGSDLTSLAKEAAMEPIRDLGDKLMFADFDKIRGIEIKDFQNALLTIKKSVSSESLQKYEEWSSKFGSNGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationLADLIINSKGNKDTV
HHHHHCCCCCCCCEE		31.3719795423
120PhosphorylationLMAEGNGSPSLSSSS
HHHCCCCCCCCCCCC		18.4721440633
125PhosphorylationNGSPSLSSSSSVLGL
CCCCCCCCCCCEECC		39.2621551504
126PhosphorylationGSPSLSSSSSVLGLG
CCCCCCCCCCEECCC		24.2121551504
128PhosphorylationPSLSSSSSVLGLGTG
CCCCCCCCEECCCCC		24.2519779198
252PhosphorylationERKTNYKSRASLDNF
HHHCCCCCHHHHCCC		23.7919823750
255PhosphorylationTNYKSRASLDNFSSS
CCCCCHHHHCCCCCC		34.8419823750
278PhosphorylationNSLIKRRSLDVVRTS
CHHHHHHCCEEEECC		32.7122369663
284PhosphorylationRSLDVVRTSGERVRT
HCCEEEECCCCCCCC		29.4923749301
285PhosphorylationSLDVVRTSGERVRTP
CCEEEECCCCCCCCC		28.2622369663
295UbiquitinationRVRTPVRKSMEAAEI
CCCCCHHHHHHHHHH		55.1519722269
329PhosphorylationVSNNGSHSNELQIRY
CCCCCCCCCCEEEEE		33.4327017623
352PhosphorylationRYDYKKPTVNRPIIK
CCCCCCCCCCCCCCC		39.0128889911
360PhosphorylationVNRPIIKSPTLNRQN
CCCCCCCCCCCCCCC		16.8321440633
368PhosphorylationPTLNRQNSKSSRNIP
CCCCCCCCCCCCCCC		26.1021440633
370PhosphorylationLNRQNSKSSRNIPTN
CCCCCCCCCCCCCCC		34.0621440633
391PhosphorylationKSNTNKVSRRNEQNL
CCCCCCCCHHHHCCC		27.4224961812
401PhosphorylationNEQNLEPSSPVLVSA
HHCCCCCCCCEEEEE		37.5921440633
402PhosphorylationEQNLEPSSPVLVSAT
HCCCCCCCCEEEEEE		29.7319823750
407PhosphorylationPSSPVLVSATAVPAE
CCCCEEEEEEEECCC		18.7519823750
409PhosphorylationSPVLVSATAVPAESK
CCEEEEEEEECCCCC		22.2328889911
415PhosphorylationATAVPAESKPMRSKS
EEEECCCCCCCCCCC		44.1328889911
420PhosphorylationAESKPMRSKSGTPDK
CCCCCCCCCCCCCCC		25.5621440633
422PhosphorylationSKPMRSKSGTPDKES
CCCCCCCCCCCCCCC		49.5022369663
424PhosphorylationPMRSKSGTPDKESSA
CCCCCCCCCCCCCCC		35.0920377248
429PhosphorylationSGTPDKESSASSSLD
CCCCCCCCCCCCCCH		36.6222369663
430PhosphorylationGTPDKESSASSSLDS
CCCCCCCCCCCCCHH		33.0122369663
432PhosphorylationPDKESSASSSLDSRK
CCCCCCCCCCCHHHH		23.5422369663
433PhosphorylationDKESSASSSLDSRKE
CCCCCCCCCCHHHHH		34.3422369663
434PhosphorylationKESSASSSLDSRKED
CCCCCCCCCHHHHHH		33.4322369663
437PhosphorylationSASSSLDSRKEDILK
CCCCCCHHHHHHHHH		51.0121440633
530PhosphorylationAVATESNSTFFSVSA
HHHCCCCCCEEEECH		35.5527017623
531PhosphorylationVATESNSTFFSVSAS
HHCCCCCCEEEECHH		32.7127017623
539PhosphorylationFFSVSASSLLSKYLG
EEEECHHHHHHHHHC		32.8027017623
599PhosphorylationTELLIQWSSLSSATA
HHHHHHHHCCCHHCC		12.6728889911
605PhosphorylationWSSLSSATAQSEDRN
HHCCCHHCCCCCCCC		27.4628889911
608PhosphorylationLSSATAQSEDRNNTL
CCHHCCCCCCCCCCC		38.7128889911
735PhosphorylationLTIKKSVSSESLQKY
HHHHHCCCHHHHHHH		35.1623749301
738PhosphorylationKKSVSSESLQKYEEW
HHCCCHHHHHHHHHH		37.7423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBP6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBP6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBP6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSP1_YEASTLSP1physical
11805837
TOP2_YEASTTOP2physical
11805837
PIL1_YEASTPIL1physical
11805837
BMH2_YEASTBMH2physical
16554755
SYEC_YEASTGUS1physical
16554755
PIL1_YEASTPIL1physical
16554755
SSB2_YEASTSSB2physical
16554755
ATG15_YEASTATG15genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RS3A1_YEASTRPS1Agenetic
27708008
PET8_YEASTPET8genetic
27708008
SCC1_YEASTMCD1genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
PRS8_YEASTRPT6genetic
27708008
YIP1_YEASTYIP1genetic
27708008
ORC6_YEASTORC6genetic
27708008
NU192_YEASTNUP192genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SYFB_YEASTFRS1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
SMP3_YEASTSMP3genetic
27708008
IWS1_YEASTSPN1genetic
27708008
AP2A_YEASTAPL3genetic
27708008
REI1_YEASTREI1genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
ACOX_YEASTPOX1genetic
27708008
SSBP1_YEASTSBP1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
AP3S_YEASTAPS3genetic
27708008
NCA3_YEASTNCA3genetic
27708008
DHOM_YEASTHOM6genetic
27708008
YJ9K_YEASTYJR146Wgenetic
27708008
PRR1_YEASTPRR1genetic
27708008
RCN1_YEASTRCN1genetic
27708008
YK21_YEASTYKR041Wgenetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
NDI1_YEASTNDI1genetic
27708008
ERG5_YEASTERG5genetic
27708008
MIC27_YEASTMIC27genetic
27708008
CYB5_YEASTCYB5genetic
27708008
MET22_YEASTMET22genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBP6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND THR-424, ANDMASS SPECTROMETRY.

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