| UniProt ID | CYK2_YEAST | |
|---|---|---|
| UniProt AC | Q05080 | |
| Protein Name | Cytokinesis protein 2 | |
| Gene Name | HOF1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 669 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Bud neck. | |
| Protein Description | Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contraction-like action.. | |
| Protein Sequence | MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGTNMDYGKLNETFNVVLSVEKARAQSHSKQSEILFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENNMIGAKRVEHNKRELLKWESNSQEYKVQLDVLKQEYKASQKFWIHEWAQLSCELQEMENARISFLQSKLQQFATSSMETYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRLKHKTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLKETENKRKLASIDKYEKPLPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSVLRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMESMTTSVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNEDDYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSKPGTKTGNIMDERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKGDYLLITEIVNKDWYKGEVYDNDRIDRNHRIGLIPYNFIQLLHQGL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 117 | Phosphorylation | ANLQARYTTLSGKIE HHHHHHHHHHHHHHH | 18.73 | 27017623 | |
| 120 | Phosphorylation | QARYTTLSGKIERLR HHHHHHHHHHHHHHH | 35.63 | 27017623 | |
| 181 | Phosphorylation | LLKWESNSQEYKVQL HHHCCCCCCCEEHHH | 33.40 | 30377154 | |
| 226 | Phosphorylation | ARISFLQSKLQQFAT HHHHHHHHHHHHHHH | 37.16 | 30377154 | |
| 286 | Phosphorylation | SKGDMNSSANWAQMS CCCCCCCCCCHHHHH | 22.18 | 19779198 | |
| 293 | Phosphorylation | SANWAQMSSISTTSK CCCHHHHHHCCCCCH | 16.67 | 27017623 | |
| 296 | Phosphorylation | WAQMSSISTTSKKTE HHHHHHCCCCCHHHH | 27.81 | 27017623 | |
| 297 | Phosphorylation | AQMSSISTTSKKTES HHHHHCCCCCHHHHH | 33.16 | 27017623 | |
| 298 | Phosphorylation | QMSSISTTSKKTESY HHHHCCCCCHHHHHH | 31.58 | 27017623 | |
| 299 | Phosphorylation | MSSISTTSKKTESYM HHHCCCCCHHHHHHH | 32.04 | 19779198 | |
| 313 | Phosphorylation | MDNIRKLSSQLKETE HHHHHHHHHHHHHHH | 21.05 | 23749301 | |
| 314 | Phosphorylation | DNIRKLSSQLKETEN HHHHHHHHHHHHHHH | 50.39 | 19823750 | |
| 319 | Phosphorylation | LSSQLKETENKRKLA HHHHHHHHHHHHHHH | 43.18 | 19823750 | |
| 337 | Phosphorylation | KYEKPLPSPEVTMAT CCCCCCCCCCCEEEE | 41.18 | 21440633 | |
| 341 | Phosphorylation | PLPSPEVTMATQFRN CCCCCCCEEEEECCC | 10.22 | 21440633 | |
| 344 | Phosphorylation | SPEVTMATQFRNSTP CCCCEEEEECCCCCC | 19.88 | 21440633 | |
| 349 | Phosphorylation | MATQFRNSTPVIRNE EEEECCCCCCCCCCC | 29.81 | 21440633 | |
| 350 | Phosphorylation | ATQFRNSTPVIRNET EEECCCCCCCCCCCC | 25.73 | 21440633 | |
| 364 | Phosphorylation | TKVVANPTLSLRSSP CEEEECCCEECCCCC | 28.87 | 28152593 | |
| 366 | Phosphorylation | VVANPTLSLRSSPVQ EEECCCEECCCCCEE | 24.98 | 25752575 | |
| 369 | Phosphorylation | NPTLSLRSSPVQLQS CCCEECCCCCEECCC | 44.26 | 28889911 | |
| 370 | Phosphorylation | PTLSLRSSPVQLQSN CCEECCCCCEECCCC | 23.74 | 21082442 | |
| 421 | Phosphorylation | MVHKRNQSLSSPSES EEEECCCCCCCCCCC | 33.49 | 19823750 | |
| 423 | Phosphorylation | HKRNQSLSSPSESSS EECCCCCCCCCCCCC | 45.51 | 20377248 | |
| 424 | Phosphorylation | KRNQSLSSPSESSSS ECCCCCCCCCCCCCC | 37.43 | 23749301 | |
| 426 | Phosphorylation | NQSLSSPSESSSSNP CCCCCCCCCCCCCCC | 52.65 | 21440633 | |
| 429 | Phosphorylation | LSSPSESSSSNPTDF CCCCCCCCCCCCCCH | 33.46 | 23749301 | |
| 430 | Phosphorylation | SSPSESSSSNPTDFS CCCCCCCCCCCCCHH | 43.33 | 19779198 | |
| 431 | Phosphorylation | SPSESSSSNPTDFSH CCCCCCCCCCCCHHH | 49.10 | 23749301 | |
| 444 | Phosphorylation | SHIKKRQSMESMTTS HHHHHHHHHHHHHHH | 28.66 | 28889911 | |
| 447 | Phosphorylation | KKRQSMESMTTSVSS HHHHHHHHHHHHHHH | 16.88 | 28889911 | |
| 449 | Phosphorylation | RQSMESMTTSVSSMA HHHHHHHHHHHHHHH | 25.79 | 19779198 | |
| 451 | Phosphorylation | SMESMTTSVSSMANS HHHHHHHHHHHHHHC | 15.73 | 19779198 | |
| 467 | Ubiquitination | DDSQRFAKSWNSSNR CHHHHHHHHCCCCCC | 53.98 | 23749301 | |
| 478 | Phosphorylation | SSNRKRKSMSHLQVP CCCCCCCCCCCCCCC | 29.56 | 28889911 | |
| 480 | Phosphorylation | NRKRKSMSHLQVPSS CCCCCCCCCCCCCCC | 28.30 | 28889911 | |
| 501 | Phosphorylation | DGGRTPNSAHNLNED CCCCCCCCCCCCCCC | 31.91 | 28889911 | |
| 516 | Phosphorylation | DYNTRRDTSTSTILF CCCCCCCCCCCEEEE | 31.90 | 23749301 | |
| 517 | Phosphorylation | YNTRRDTSTSTILFK CCCCCCCCCCEEEEC | 25.34 | 23749301 | |
| 519 | Phosphorylation | TRRDTSTSTILFKPP CCCCCCCCEEEECCC | 17.14 | 21082442 | |
| 524 | Ubiquitination | STSTILFKPPVAVRG CCCEEEECCCEEECC | 44.99 | 17644757 | |
| 563 | Phosphorylation | YEMERIQSSSKPGTK HHHHHHHCCCCCCCC | 33.92 | 23749301 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CYK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CYK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, AND MASSSPECTROMETRY. | |
