dbPTM

GIP3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GIP3_YEAST
UniProt AC	Q03016
Protein Name	GLC7-interacting protein 3
Gene Name	GIP3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1276
Subcellular Localization	Cytoplasm . Endoplasmic reticulum .
Protein Description
Protein Sequence	MITNTEFDVPVDWLYKGKSRRKTNTKPSRPSTSPASSSSTSSSKNGDNSTSGNRSSNDKPRARSSSVSNAALCNTEKPDLKRNDGNTSASDTDNIPLLTPINSGNRSDSADIDNPATVDAIDLIDNDDNGSSTQFVRKKRSTSISNAVVSSKPRLASSAINATASSSVGKGKHPPISSPSNATLKRSNSTSGEKTKRSIFGSLFSKRSTSSSASTAKKPLPVVNTSTTENESGGIKAVATPDPRVKEISSPMRGVAPTASKPQTPILPSPALAVKDLSTVSLKRVSFAVDKFESDPPQQLPSRTPKKGNILIPDDMISEVPSISVGISSSNQSAKSTNSNIKGPLYTKKSKEYILALENQKLALREAAKHQQEAHFAANRIAFEVANFKTASDAGGKLTEKSSEGTITKQREEVSPPNVEADRELENNKLAENLSKAGIDKPIHMHEHYFKEPDQDKYQDGHSIENNEVTLDVIYTRCCHLREILPIPSTLRQVKDKTAPLQILKFLNPKPTLIDILSFCDFITIAPIHTIVFDNVALNQDMFRIIISALVNSTVLDKLSLRNVRIDQDGWKLLCKFLLLNKSLNKLDISQTKIKSDLAESLYRHNMDWNLFTDVLSQRSHKPIEELLFNGIQFSKIPYSCFARLLTSFATQKNFPESGIRLGLAGATTSNISQDCLKFIFNWMSQYNVQGVDLAFNDLSTMIKPMVGKLSALSYDNLRYFILNSTNISTSYDLALLLKYLSKLPNLIFLDLSNLSQCFPDILPYMYKYLPRFPNLKRIHLDSNNLTLKELAVVCNILIKCKSLSHVSMTNQNVENFYLMNGTDSPVQQTNTDGDLDSSSTLDVKGQFAKNSFSSTLYAFARDSPNLIGLDFDYDLISEEIQSRIALCLMRNMKRTMDSTFQLDELDSQDDLLFDGSLVTMTAESVLEKLNLLSDKSTKVKKDTTKRYLLKKYIEKFHILHHNVQHTIDTMFEKRKSGELPLQEKENLVRLLLLEQNLCNILELFSHNPNLNDVLGSSRDDSKESVDSSEDSKLPALKHVESGYHVPEEKIQPENDVITARPHLMATDSGKTIDVFTGKPLVFKHTSSSTSVGCKKQEEEEGELHKWGFFVQQQRSLYPENESTRQTPFASGDTPINTETAGKSTSSPSVSTSNNETATTSLFSPANPKILPKIPSGAVLRSAIMKAKGIDSIDDLIQNVNSNNIELENIYGESIQNSASTFTPGVDSDVSAPNTDKGSVETLPAVSTDDPNCEVKVTATYDKLLNNLSMERSIRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	RKTNTKPSRPSTSPA CCCCCCCCCCCCCCC	59.38	20377248
31	Phosphorylation	NTKPSRPSTSPASSS CCCCCCCCCCCCCCC	40.17	23749301
32	Phosphorylation	TKPSRPSTSPASSSS CCCCCCCCCCCCCCC	41.22	20377248
33	Phosphorylation	KPSRPSTSPASSSST CCCCCCCCCCCCCCC	23.86	21440633
36	Phosphorylation	RPSTSPASSSSTSSS CCCCCCCCCCCCCCC	33.85	21440633
38	Phosphorylation	STSPASSSSTSSSKN CCCCCCCCCCCCCCC	34.83	21551504
39	Phosphorylation	TSPASSSSTSSSKNG CCCCCCCCCCCCCCC	33.97	21551504
41	Phosphorylation	PASSSSTSSSKNGDN CCCCCCCCCCCCCCC	34.26	21551504
42	Phosphorylation	ASSSSTSSSKNGDNS CCCCCCCCCCCCCCC	45.48	21551504
43	Phosphorylation	SSSSTSSSKNGDNST CCCCCCCCCCCCCCC	29.88	21551504
51	Phosphorylation	KNGDNSTSGNRSSND CCCCCCCCCCCCCCC	33.61	23749301
55	Phosphorylation	NSTSGNRSSNDKPRA CCCCCCCCCCCCCCC	37.18	21440633
56	Phosphorylation	STSGNRSSNDKPRAR CCCCCCCCCCCCCCC	45.90	28889911
64	Phosphorylation	NDKPRARSSSVSNAA CCCCCCCCCCHHHHH	26.44	17330950
65	Phosphorylation	DKPRARSSSVSNAAL CCCCCCCCCHHHHHH	29.25	25533186
66	Phosphorylation	KPRARSSSVSNAALC CCCCCCCCHHHHHHC	30.71	17330950
68	Phosphorylation	RARSSSVSNAALCNT CCCCCCHHHHHHCCC	23.77	22890988
75	Phosphorylation	SNAALCNTEKPDLKR HHHHHCCCCCCCCCC	44.37	22890988
87	Phosphorylation	LKRNDGNTSASDTDN CCCCCCCCCCCCCCC	31.06	28889911
92	Phosphorylation	GNTSASDTDNIPLLT CCCCCCCCCCCCCCC	28.57	28889911
99	Phosphorylation	TDNIPLLTPINSGNR CCCCCCCCCCCCCCC	29.79	21082442
103	Phosphorylation	PLLTPINSGNRSDSA CCCCCCCCCCCCCCC	37.86	21082442
107	Phosphorylation	PINSGNRSDSADIDN CCCCCCCCCCCCCCC	39.66	28889911
109	Phosphorylation	NSGNRSDSADIDNPA CCCCCCCCCCCCCCC	29.14	28889911
141	Phosphorylation	QFVRKKRSTSISNAV HHCCCCCCCCHHHHH	35.07	22890988
142	Phosphorylation	FVRKKRSTSISNAVV HCCCCCCCCHHHHHH	33.83	17330950
143	Phosphorylation	VRKKRSTSISNAVVS CCCCCCCCHHHHHHC	25.85	17330950
145	Phosphorylation	KKRSTSISNAVVSSK CCCCCCHHHHHHCCC	20.64	22890988
150	Phosphorylation	SISNAVVSSKPRLAS CHHHHHHCCCCCHHH	26.50	22890988
151	Phosphorylation	ISNAVVSSKPRLASS HHHHHHCCCCCHHHH	34.76	22890988
167	Phosphorylation	INATASSSVGKGKHP HHHHCCCCCCCCCCC	32.18	17563356
177	Phosphorylation	KGKHPPISSPSNATL CCCCCCCCCCCCCCC	41.80	21551504
178	Phosphorylation	GKHPPISSPSNATLK CCCCCCCCCCCCCCC	32.82	28889911
180	Phosphorylation	HPPISSPSNATLKRS CCCCCCCCCCCCCCC	40.83	28889911
183	Phosphorylation	ISSPSNATLKRSNST CCCCCCCCCCCCCCC	36.74	21440633
208	Phosphorylation	GSLFSKRSTSSSAST HHHHCCCCCCCCCCC	36.06	21440633
209	Phosphorylation	SLFSKRSTSSSASTA HHHCCCCCCCCCCCC	36.34	28889911
210	Phosphorylation	LFSKRSTSSSASTAK HHCCCCCCCCCCCCC	24.44	28889911
212	Phosphorylation	SKRSTSSSASTAKKP CCCCCCCCCCCCCCC	26.46	23749301
240	Phosphorylation	GGIKAVATPDPRVKE CCEEEEECCCCCHHH	22.94	21440633
249	Phosphorylation	DPRVKEISSPMRGVA CCCHHHCCCCCCCCC	29.49	28152593
250	Phosphorylation	PRVKEISSPMRGVAP CCHHHCCCCCCCCCC	28.51	25521595
258	Phosphorylation	PMRGVAPTASKPQTP CCCCCCCCCCCCCCC	33.55	22369663
260	Phosphorylation	RGVAPTASKPQTPIL CCCCCCCCCCCCCCC	47.55	22369663
264	Phosphorylation	PTASKPQTPILPSPA CCCCCCCCCCCCCCC	22.33	22369663
269	Phosphorylation	PQTPILPSPALAVKD CCCCCCCCCCEEECC	21.25	17330950
401	Ubiquitination	AGGKLTEKSSEGTIT CCCCCCCCCCCCCCC	54.79	23749301
402	Phosphorylation	GGKLTEKSSEGTITK CCCCCCCCCCCCCCE	27.65	28889911
403	Phosphorylation	GKLTEKSSEGTITKQ CCCCCCCCCCCCCEE	51.63	28889911
458	Phosphorylation	KEPDQDKYQDGHSIE CCCCCCCCCCCCCCC	21.81	22369663
463	Phosphorylation	DKYQDGHSIENNEVT CCCCCCCCCCCCCEE	36.81	22369663
470	Phosphorylation	SIENNEVTLDVIYTR CCCCCCEEEEHHEEE	15.86	22369663
475	Phosphorylation	EVTLDVIYTRCCHLR CEEEEHHEEEECCHH	6.49	22369663
476	Phosphorylation	VTLDVIYTRCCHLRE EEEEHHEEEECCHHH	13.20	22369663
498	Phosphorylation	LRQVKDKTAPLQILK HHHHCCCCCCHHHHH	43.57	19795423
874	Phosphorylation	LIGLDFDYDLISEEI EEECCCCHHHCCHHH	16.79	27017623
878	Phosphorylation	DFDYDLISEEIQSRI CCCHHHCCHHHHHHH	36.15	27017623
925	Phosphorylation	LVTMTAESVLEKLNL EEEEEHHHHHHHHCC	29.54	28889911
934	Phosphorylation	LEKLNLLSDKSTKVK HHHHCCCCCCCCCCC	46.27	28889911
937	Phosphorylation	LNLLSDKSTKVKKDT HCCCCCCCCCCCCHH	38.15	28889911
938	Phosphorylation	NLLSDKSTKVKKDTT CCCCCCCCCCCCHHH	45.67	28889911
977	Phosphorylation	TMFEKRKSGELPLQE HHHHHHHCCCCCHHH	41.34	21440633
1022	Phosphorylation	LGSSRDDSKESVDSS CCCCCCCCHHHCCCC	42.48	19779198
1025	Phosphorylation	SRDDSKESVDSSEDS CCCCCHHHCCCCCCC	34.65	22369663
1028	Phosphorylation	DSKESVDSSEDSKLP CCHHHCCCCCCCCCC	33.21	22369663
1029	Phosphorylation	SKESVDSSEDSKLPA CHHHCCCCCCCCCCH	40.74	22369663
1032	Phosphorylation	SVDSSEDSKLPALKH HCCCCCCCCCCHHHH	31.85	26447709
1042	Phosphorylation	PALKHVESGYHVPEE CHHHHHHCCCCCCHH	43.49	20377248
1044	Phosphorylation	LKHVESGYHVPEEKI HHHHHCCCCCCHHHC	14.66	21440633
1059	Phosphorylation	QPENDVITARPHLMA CCCCCCCCCCCCEEE	19.23	21440633
1067	Phosphorylation	ARPHLMATDSGKTID CCCCEEECCCCCEEE	19.41	19823750
1069	Phosphorylation	PHLMATDSGKTIDVF CCEEECCCCCEEEEE	37.52	20377248
1072	Phosphorylation	MATDSGKTIDVFTGK EECCCCCEEEEECCC	26.40	23607784
1077	Phosphorylation	GKTIDVFTGKPLVFK CCEEEEECCCEEEEE	44.11	23607784
1079	Acetylation	TIDVFTGKPLVFKHT EEEEECCCEEEEEEC	31.92	24489116
1087	Phosphorylation	PLVFKHTSSSTSVGC EEEEEECCCCCCCCC	23.24	28889911
1088	Phosphorylation	LVFKHTSSSTSVGCK EEEEECCCCCCCCCC	38.50	28889911
1089	Phosphorylation	VFKHTSSSTSVGCKK EEEECCCCCCCCCCC	25.19	30377154
1090	Phosphorylation	FKHTSSSTSVGCKKQ EEECCCCCCCCCCCC	29.40	30377154
1091	Phosphorylation	KHTSSSTSVGCKKQE EECCCCCCCCCCCCC	20.61	30377154
1176	Phosphorylation	KILPKIPSGAVLRSA CCCCCCCCCHHHHHH	42.74	21440633
1263	Acetylation	KVTATYDKLLNNLSM EEEECHHHHHHHCCC	44.45	24489116
1269	Phosphorylation	DKLLNNLSMERSIRL HHHHHHCCCCCCCCC	22.26	21440633
1273	Phosphorylation	NNLSMERSIRL---- HHCCCCCCCCC----	9.96	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GIP3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GIP3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GIP3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLO3_YEAST	GLO3	genetic	16269340
ATC3_YEAST	DRS2	genetic	16269340
SEC62_YEAST	SEC62	genetic	16269340
DAP1_YEAST	DAP1	genetic	16269340
AP3D_YEAST	APL5	genetic	16269340
2ABA_YEAST	CDC55	genetic	19269370
SWI6_YEAST	SWI6	genetic	19269370
SSB2_YEAST	SSB2	physical	19536198
HSP7F_YEAST	SSE1	physical	19536198
HSP71_YEAST	SSA1	physical	19536198
PP12_YEAST	GLC7	physical	20489023
RPB2_YEAST	RPB2	physical	20489023
BMT2_YEAST	BMT2	genetic	27708008
ODPB_YEAST	PDB1	genetic	27708008
SNF5_YEAST	SNF5	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
SWI6_YEAST	SWI6	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GIP3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-99; SER-103; THR-264 ANDSER-925, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-99; SER-103 AND SER-167,AND MASS SPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-68 AND SER-143,AND MASS SPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-260; THR-264AND SER-269, AND MASS SPECTROMETRY.	17330950 [Abstract]