| UniProt ID | GLO3_YEAST | |
|---|---|---|
| UniProt AC | P38682 | |
| Protein Name | ADP-ribosylation factor GTPase-activating protein GLO3 | |
| Gene Name | GLO3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 493 | |
| Subcellular Localization | Golgi apparatus . | |
| Protein Description | GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum.. | |
| Protein Sequence | MSNDEGETFATEQTTQQVFQKLGSNMENRVCFDCGNKNPTWTSVPFGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTINNLRRFKLGGNHKARDFFLKNNGKQLLNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELVLNGQDSSDSPLDTDSDASRSTSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTPKTTVTKTRSSILTASRKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDLFDQFKKEAQQEKEDEFTNSSSSTKIRQNDYDSQFMNNSKGNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLTPKFAKLGFGMTMNDANDLAKQQKESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSFDEAANREAHDKLKTFDNATSISSSSYFGEDKEVDEFGNPINSSGSGAGNFDGRNSNNGFIDFNASADDELQMLRDVVEQGAEKLGSYLRDYLRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSNDEGETF ------CCCCCCCCC | 53.65 | 28152593 | |
| 75 | Acetylation | VKSSTLDKWTINNLR EECCCCCCEEECCCC | 49.72 | 24489116 | |
| 113 | Acetylation | NTANVDAKTKYTSPV HHCCCCCCCCCCCHH | 40.88 | 24489116 | |
| 118 | Phosphorylation | DAKTKYTSPVAKKYK CCCCCCCCHHHHHEE | 17.81 | 23749301 | |
| 134 | Acetylation | HLDKKVQKDMELYPS ECCCCHHHCHHHCCH | 63.13 | 24489116 | |
| 139 | Phosphorylation | VQKDMELYPSELVLN HHHCHHHCCHHEEEC | 7.45 | 22369663 | |
| 141 | Phosphorylation | KDMELYPSELVLNGQ HCHHHCCHHEEECCC | 29.97 | 22369663 | |
| 150 | Phosphorylation | LVLNGQDSSDSPLDT EEECCCCCCCCCCCC | 28.32 | 25521595 | |
| 151 | Phosphorylation | VLNGQDSSDSPLDTD EECCCCCCCCCCCCC | 50.85 | 22369663 | |
| 153 | Phosphorylation | NGQDSSDSPLDTDSD CCCCCCCCCCCCCCC | 29.34 | 22369663 | |
| 157 | Phosphorylation | SSDSPLDTDSDASRS CCCCCCCCCCCHHHC | 45.12 | 25521595 | |
| 159 | Phosphorylation | DSPLDTDSDASRSTS CCCCCCCCCHHHCCC | 36.85 | 20377248 | |
| 162 | Phosphorylation | LDTDSDASRSTSKEN CCCCCCHHHCCCCCC | 31.58 | 20377248 | |
| 164 | Phosphorylation | TDSDASRSTSKENSV CCCCHHHCCCCCCCH | 34.24 | 20377248 | |
| 165 | Phosphorylation | DSDASRSTSKENSVD CCCHHHCCCCCCCHH | 42.58 | 22369663 | |
| 166 | Phosphorylation | SDASRSTSKENSVDD CCHHHCCCCCCCHHH | 38.94 | 22369663 | |
| 167 | Ubiquitination | DASRSTSKENSVDDF CHHHCCCCCCCHHHH | 62.09 | 24961812 | |
| 167 | Acetylation | DASRSTSKENSVDDF CHHHCCCCCCCHHHH | 62.09 | 24489116 | |
| 170 | Phosphorylation | RSTSKENSVDDFFSN HCCCCCCCHHHHHHC | 28.19 | 22369663 | |
| 176 | Phosphorylation | NSVDDFFSNWQKPSS CCHHHHHHCCCCCCC | 36.83 | 22369663 | |
| 180 | Acetylation | DFFSNWQKPSSNSSS HHHHCCCCCCCCCCC | 38.18 | 24489116 | |
| 180 | Ubiquitination | DFFSNWQKPSSNSSS HHHHCCCCCCCCCCC | 38.18 | 24961812 | |
| 182 | Phosphorylation | FSNWQKPSSNSSSKL HHCCCCCCCCCCCCE | 49.54 | 22369663 | |
| 183 | Phosphorylation | SNWQKPSSNSSSKLN HCCCCCCCCCCCCEE | 49.62 | 20377248 | |
| 185 | Phosphorylation | WQKPSSNSSSKLNVN CCCCCCCCCCCEEEC | 37.63 | 20377248 | |
| 186 | Phosphorylation | QKPSSNSSSKLNVNT CCCCCCCCCCEEECC | 35.42 | 22369663 | |
| 187 | Phosphorylation | KPSSNSSSKLNVNTG CCCCCCCCCEEECCC | 40.77 | 20377248 | |
| 188 | Ubiquitination | PSSNSSSKLNVNTGS CCCCCCCCEEECCCC | 46.13 | 24961812 | |
| 193 | Phosphorylation | SSKLNVNTGSLAPKN CCCEEECCCCCCCCC | 24.70 | 30377154 | |
| 195 | Phosphorylation | KLNVNTGSLAPKNNT CEEECCCCCCCCCCC | 21.22 | 21440633 | |
| 199 | Ubiquitination | NTGSLAPKNNTTGST CCCCCCCCCCCCCCC | 58.17 | 23749301 | |
| 203 | Phosphorylation | LAPKNNTTGSTPKTT CCCCCCCCCCCCCCE | 31.12 | 28889911 | |
| 205 | Phosphorylation | PKNNTTGSTPKTTVT CCCCCCCCCCCCEEE | 39.17 | 28889911 | |
| 206 | Phosphorylation | KNNTTGSTPKTTVTK CCCCCCCCCCCEEEE | 30.10 | 23749301 | |
| 214 | Phosphorylation | PKTTVTKTRSSILTA CCCEEEECHHHHHHH | 26.81 | 22369663 | |
| 216 | Phosphorylation | TTVTKTRSSILTASR CEEEECHHHHHHHCC | 27.28 | 22369663 | |
| 217 | Phosphorylation | TVTKTRSSILTASRK EEEECHHHHHHHCCC | 20.51 | 22369663 | |
| 222 | Phosphorylation | RSSILTASRKKPVLN HHHHHHHCCCCCCCC | 39.12 | 30377154 | |
| 237 | Phosphorylation | SQDKKKHSILSSSRK CCHHHHCCHHHCCCC | 33.82 | 30377154 | |
| 241 | Phosphorylation | KKHSILSSSRKPTRL HHCCHHHCCCCCCCC | 30.62 | 30377154 | |
| 246 | Phosphorylation | LSSSRKPTRLTAKKV HHCCCCCCCCCCEEC | 41.15 | 23749301 | |
| 256 | Phosphorylation | TAKKVDKSQAEDLFD CCEECCHHHHHHHHH | 30.11 | 21551504 | |
| 266 | Succinylation | EDLFDQFKKEAQQEK HHHHHHHHHHHHHHH | 44.03 | 23954790 | |
| 266 | Acetylation | EDLFDQFKKEAQQEK HHHHHHHHHHHHHHH | 44.03 | 24489116 | |
| 273 | Ubiquitination | KKEAQQEKEDEFTNS HHHHHHHHHHHCCCC | 67.15 | 23749301 | |
| 278 | Phosphorylation | QEKEDEFTNSSSSTK HHHHHHCCCCCCCCE | 31.95 | 22369663 | |
| 280 | Phosphorylation | KEDEFTNSSSSTKIR HHHHCCCCCCCCEEC | 28.65 | 22369663 | |
| 281 | Phosphorylation | EDEFTNSSSSTKIRQ HHHCCCCCCCCEECC | 30.31 | 22369663 | |
| 282 | Phosphorylation | DEFTNSSSSTKIRQN HHCCCCCCCCEECCC | 41.68 | 25521595 | |
| 283 | Phosphorylation | EFTNSSSSTKIRQND HCCCCCCCCEECCCC | 35.35 | 22369663 | |
| 284 | Phosphorylation | FTNSSSSTKIRQNDY CCCCCCCCEECCCCC | 32.22 | 25521595 | |
| 293 | Phosphorylation | IRQNDYDSQFMNNSK ECCCCCCHHHCCCCC | 21.06 | 21440633 | |
| 299 | Phosphorylation | DSQFMNNSKGNNNNS CHHHCCCCCCCCCCC | 36.61 | 21440633 | |
| 306 | Phosphorylation | SKGNNNNSIDDINTQ CCCCCCCCCCCCCCC | 29.53 | 22369663 | |
| 312 | Phosphorylation | NSIDDINTQPDEFND CCCCCCCCCHHHHHH | 41.64 | 22369663 | |
| 324 | Phosphorylation | FNDFLNDTSNSFDTT HHHHHHCCCCCCCCC | 28.83 | 20377248 | |
| 325 | Phosphorylation | NDFLNDTSNSFDTTR HHHHHCCCCCCCCCH | 33.08 | 22369663 | |
| 327 | Phosphorylation | FLNDTSNSFDTTRKE HHHCCCCCCCCCHHH | 25.02 | 22369663 | |
| 330 | Phosphorylation | DTSNSFDTTRKEQQD CCCCCCCCCHHHHHH | 26.87 | 22369663 | |
| 331 | Phosphorylation | TSNSFDTTRKEQQDT CCCCCCCCHHHHHHC | 41.40 | 22369663 | |
| 333 | Ubiquitination | NSFDTTRKEQQDTLT CCCCCCHHHHHHCCC | 58.75 | 24961812 | |
| 338 | Phosphorylation | TRKEQQDTLTPKFAK CHHHHHHCCCHHHHH | 28.35 | 24909858 | |
| 340 | Phosphorylation | KEQQDTLTPKFAKLG HHHHHCCCHHHHHHC | 26.90 | 25521595 | |
| 342 | Ubiquitination | QQDTLTPKFAKLGFG HHHCCCHHHHHHCCC | 53.36 | 24961812 | |
| 342 | Acetylation | QQDTLTPKFAKLGFG HHHCCCHHHHHHCCC | 53.36 | 24489116 | |
| 345 | Ubiquitination | TLTPKFAKLGFGMTM CCCHHHHHHCCCCCC | 52.88 | 24961812 | |
| 367 | Acetylation | KQQKESQKIAQGPRY HHHHHHHHHHCCCHH | 49.65 | 25381059 | |
| 386 | Ubiquitination | AERYGTQKAISSDQL HHHHCCCCCCCCCCC | 47.74 | 24961812 | |
| 389 | Phosphorylation | YGTQKAISSDQLFGR HCCCCCCCCCCCCCC | 32.49 | 22369663 | |
| 390 | Phosphorylation | GTQKAISSDQLFGRG CCCCCCCCCCCCCCC | 24.22 | 22369663 | |
| 398 | Phosphorylation | DQLFGRGSFDEAANR CCCCCCCCHHHHHCH | 28.32 | 22369663 | |
| 410 | Ubiquitination | ANREAHDKLKTFDNA HCHHHHHHHHCCCCC | 41.85 | 24961812 | |
| 413 | Phosphorylation | EAHDKLKTFDNATSI HHHHHHHCCCCCCCC | 46.81 | 22369663 | |
| 418 | Phosphorylation | LKTFDNATSISSSSY HHCCCCCCCCCCCCC | 32.61 | 22369663 | |
| 419 | Phosphorylation | KTFDNATSISSSSYF HCCCCCCCCCCCCCC | 20.33 | 22369663 | |
| 421 | Phosphorylation | FDNATSISSSSYFGE CCCCCCCCCCCCCCC | 24.76 | 22369663 | |
| 422 | Phosphorylation | DNATSISSSSYFGED CCCCCCCCCCCCCCC | 22.95 | 22369663 | |
| 423 | Phosphorylation | NATSISSSSYFGEDK CCCCCCCCCCCCCCC | 23.44 | 22369663 | |
| 424 | Phosphorylation | ATSISSSSYFGEDKE CCCCCCCCCCCCCCC | 26.82 | 22369663 | |
| 425 | Phosphorylation | TSISSSSYFGEDKEV CCCCCCCCCCCCCCC | 19.97 | 22369663 | |
| 430 | Ubiquitination | SSYFGEDKEVDEFGN CCCCCCCCCCCCCCC | 56.16 | 19722269 | |
| 442 | Phosphorylation | FGNPINSSGSGAGNF CCCCCCCCCCCCCCC | 32.27 | 28889911 | |
| 444 | Phosphorylation | NPINSSGSGAGNFDG CCCCCCCCCCCCCCC | 27.67 | 29734811 | |
| 464 | Phosphorylation | GFIDFNASADDELQM CCEECCCCCCHHHHH | 33.08 | 30377154 | |
| 482 | Ubiquitination | VVEQGAEKLGSYLRD HHHHHHHHHHHHHHH | 58.58 | 23749301 | |
| 485 | Phosphorylation | QGAEKLGSYLRDYLR HHHHHHHHHHHHHHC | 31.28 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLO3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLO3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLO3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; THR-324; SER-389;SER-390; SER-398 AND SER-419, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282; SER-306 ANDSER-398, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, AND MASSSPECTROMETRY. | |
