ZIP1_YEAST - dbPTM
ZIP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZIP1_YEAST
UniProt AC P31111
Protein Name Synaptonemal complex protein ZIP1
Gene Name ZIP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 875
Subcellular Localization Nucleus. Chromosome. Synapsed meiotic chromosomes.
Protein Description Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex..
Protein Sequence MSNFFRDSSMGFKPRPNIFAKLRVRDVDSDSSANTVVENSSNCLDVGSSIEGDDTFKKPHKTSTEQELITSMSLSQRNHGYSDDMEIGSPKKTTSTDQYNRILKNDVAAIENDTDEDFEITEVREVSEGVAKETKESHGDPNDSETTLKDSKMHEYTMTNGKAPLHTSINNSSTSSNDVLLEAFTNTQRICSNLKQELQKQQQDNAKLKVRLQSYASNSDKINEKVGKYKSCLETLQERIATLTSHKNNQETKLKDLRQNHQLYQRRISGFKTSIENLNKTINDLGKNKKEADAELMKKGKEIEYLKRELDDCSGQLSEEKIKNSSLIQEMGKNREEMIKSIENFFSEDKAHHLLQFNKFEERVHDLFEKKLQKHFDVAKDTLNVGLRNTTVELSSNTETMLKQQYEDIKENLEQKMSSSKDEMAKTINELSVTQKGLIMGVQEELLTSSGNIQTALVSEMNNTRQELLDDASQTAKNYASLENLVKAYKAEIVQSNEYEERIKHLESERSTLSSQKNQIISSLGTKEAQYEDLVKKLEAKNIEISQISGKEQSLTEKNENLSNELKKVQDQLEKLNNLNITTKSNYENKISSQNEIVKALVSENDTLKQRIQQLVEIKENEQKDHTTKLEAFQKNNEQLQKLNVEVVQLKAHELELEEQNRHLKNCLEKKETGVEESLSDVKTLKQQVIVLKSEKQDITAEKLELQDNLESLEEVTKNLQQKVQSQKRELEQKIKELEEIKNHKRNEPSKKGTQNFTKPSDSPKKNATTSNLFPNNSAAIHSPMKKCPKVDHISKSRINSSKETSKFNDEFDLSSSSNDDLELTNPSPIQIKPVRGKIKKGSNCMKPPISSRKKLLLVEDEDQSLKISKKRRRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationLITSMSLSQRNHGYS
HHHHHCHHHCCCCCC		21.5628889911
82PhosphorylationSQRNHGYSDDMEIGS
HHCCCCCCCCCCCCC		31.5527214570
89PhosphorylationSDDMEIGSPKKTTST
CCCCCCCCCCCCCCH		38.9320825495
114PhosphorylationVAAIENDTDEDFEIT
CEECCCCCCCCCEEE		53.5227214570
127PhosphorylationITEVREVSEGVAKET
EEEEEEHHHHHHHHH		24.7127214570
137PhosphorylationVAKETKESHGDPNDS
HHHHHHHHHCCCCCC		34.0327017623
144PhosphorylationSHGDPNDSETTLKDS
HHCCCCCCCCCHHHH		43.4127214570
147PhosphorylationDPNDSETTLKDSKMH
CCCCCCCCHHHHCCE		27.9725533186
156PhosphorylationKDSKMHEYTMTNGKA
HHHCCEEEECCCCCC		6.2727017623
157PhosphorylationDSKMHEYTMTNGKAP
HHCCEEEECCCCCCC		17.9727017623
341PhosphorylationNREEMIKSIENFFSE
CHHHHHHHHHHHCCC		24.9827214570
420PhosphorylationLEQKMSSSKDEMAKT
HHHHHHCCHHHHHHH		36.5027017623
481PhosphorylationQTAKNYASLENLVKA
HHHHHHHHHHHHHHH		26.3422369663
514PhosphorylationESERSTLSSQKNQII
HHHHHHHHHHHHHHH		30.7127214570
515PhosphorylationSERSTLSSQKNQIIS
HHHHHHHHHHHHHHH		48.5727214570
546PhosphorylationEAKNIEISQISGKEQ
HHCCCCHHHCCCCCH		14.5227214570
554PhosphorylationQISGKEQSLTEKNEN
HCCCCCHHHHHHHHH		38.0521440633
593PhosphorylationNYENKISSQNEIVKA
CCCCCCCCHHHHHHH		40.2627214570
678PhosphorylationKETGVEESLSDVKTL
HHHCCCHHHHHHHHH		21.4827214570
763PhosphorylationNFTKPSDSPKKNATT
CCCCCCCCCCCCCCC		42.8520825495
778PhosphorylationSNLFPNNSAAIHSPM
CCCCCCCCHHCCCCC		26.2227214570
783PhosphorylationNNSAAIHSPMKKCPK
CCCHHCCCCCCCCCC		22.1520825495
828PhosphorylationDLELTNPSPIQIKPV
CCCCCCCCCCEEECC		36.3820825495
865PhosphorylationLVEDEDQSLKISKKR
EECCCCCCCHHCHHH		43.9127214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZIP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZIP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZIP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUF2_YEASTNUF2physical
11087867
RED1_YEASTRED1genetic
10848609
MEK1_YEASTMEK1genetic
9000054
PCH2_YEASTPCH2genetic
10319812
RED1_YEASTRED1genetic
9000054
SIR2_YEASTSIR2genetic
10319812
DMC1_YEASTDMC1genetic
7590245
RAD51_YEASTRAD51genetic
7590245
SMT3_YEASTSMT3physical
16847351
RED1_YEASTRED1physical
16847351
RAD17_YEASTRAD17genetic
17174924
PCH2_YEASTPCH2genetic
17174924
CG21_YEASTCLB1genetic
10619027
MEK1_YEASTMEK1genetic
10848609
PCH2_YEASTPCH2genetic
18305165
SIR2_YEASTSIR2genetic
18305165
MAD3_YEASTMAD3genetic
20080752
DOT1_YEASTDOT1genetic
11029058
SPO11_YEASTSPO11genetic
20428251
MEK1_YEASTMEK1genetic
20888230
NDT80_YEASTNDT80genetic
21471004
PCH2_YEASTPCH2genetic
21471004
LCD1_YEASTLCD1genetic
21693576
CDC5_YEASTCDC5genetic
21795394
SWE1_YEASTSWE1genetic
21795394
CG21_YEASTCLB1genetic
21795394
CDK1_YEASTCDC28genetic
21795394
XRS2_YEASTXRS2genetic
22072981
PCH2_YEASTPCH2genetic
22072981
ATM_YEASTTEL1genetic
22072981
SPC72_YEASTSPC72physical
22875988
AP2A_YEASTAPL3physical
22875988
BL1S4_YEASTCNL1physical
22875988
MAD1_YEASTMAD1physical
22875988
ATG1_YEASTATG1physical
22875988
SEC9_YEASTSEC9physical
22875988
SPR3_YEASTSPR3physical
22875988
NNF2_YEASTNNF2physical
22875988
ETP1_YEASTETP1physical
22875988
NOT3_YEASTNOT3physical
22875988
TPM2_YEASTTPM2physical
22875988
PAN1_YEASTPAN1physical
22875988
MPS3_YEASTMPS3physical
22875988
NNF1_YEASTNNF1physical
22875988
BLI1_YEASTBLI1physical
22875988
LHS1_YEASTLHS1physical
22875988
SMY1_YEASTSMY1physical
22875988
DID2_YEASTDID2physical
22875988
SPA2_YEASTSPA2physical
22875988
FAR10_YEASTFAR10physical
22875988
SPC24_YEASTSPC24physical
22875988
MET4_YEASTMET4physical
22875988
AF9_YEASTYAF9physical
22875988
NUF2_YEASTNUF2physical
22875988
MYO2_YEASTMYO2physical
22875988
RQC2_YEASTTAE2physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
LAM4_YEASTYHR080Cphysical
22875988
DOT1_YEASTDOT1genetic
23382701
SIR2_YEASTSIR2genetic
28357333
SAS2_YEASTSAS2genetic
28357333
DOT1_YEASTDOT1genetic
28357333
PCH2_YEASTPCH2genetic
27257060
MOT1_YEASTMOT1genetic
27257060
HOP1_YEASTHOP1genetic
27257060
PP4C_YEASTPPH3genetic
27257060
RAD51_YEASTRAD51genetic
27257060
RAD54_YEASTRAD54genetic
27257060
MSH4_YEASTMSH4genetic
27184389
MLH3_YEASTMLH3genetic
27184389
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZIP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, AND MASSSPECTROMETRY.

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