| UniProt ID | MPS3_YEAST | |
|---|---|---|
| UniProt AC | P47069 | |
| Protein Name | Spindle pole body assembly component MPS3 | |
| Gene Name | MPS3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 682 | |
| Subcellular Localization |
Nucleus membrane Single-pass type II membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Localizes to the spindle pole body half bridge throughout the cell cycle. |
|
| Protein Description | Required for the first step of spindle pole body duplication in G1. Essential for nuclear division and fusion. Functions in sister chromatid cohesion establishment. Connects the spindle pole body with the nuclear envelope through its interaction with MPS2 and mediates meiotic bouquet formation and rapid chromosome movements in meiotic prophase. Functions as an integral membrane anchor for telomeres and is a nuclear receptor for the SIR4 pathway of telomere tethering and gene inactivation. recruits double-strand breaks (DSBs) to the nuclear periphery for chromosome healing.. | |
| Protein Sequence | MNNSNEHRREEAGAANEQMPYNKAVKSAYADVLKDKMNREQEISLRAIKKGIYTDGGETDNYDMDKENDSAYEMFKKNLDFPLDQHNDDDDDDPYIEDNGQETDGYSDEDYTDEADKSFIEDSDSDSYDLESNSDFEENLESSGEAKKLKWRTYIFYGGLFFVFYFFGSFLMTTVKNNDLESHSSGATSSPGKSFSNLQKQVNHLYSELSKRDEKHSSELDKTVKIIVSQFEKNIKRLLPSNLVNFENDINSLTKQVETISTSMSELQRRNHKFTVENVTQWQDQLVKQLDTHLPQEIPVVINNSSSLLIIPELHNYLSALISDVIESPGIGTAGSAESRWEYDLNRYVKEILSNELQYIDKDYFIQEMNRRLQSNKQEIWEEITNRLETQQQQQQQQVQQDYSNVPQQYSSILMKRLIHQIYNSNQHQWEDDLDFATYVQGTKLLNHLTSPTWRQGSGVQPIELLTDSKQSSSTYWQCENEPGCSWAIRFKTPLYLTKISYMHGRFTNNLHIMNSAPRLISLYVKLSQTKEIKALQTLANQYGFGQHHKRDRNYIKIAKFEYRLTDSRIRQQMYLPPWFIQLKPLVRSIVFQVDENYGNKKFISLRKFIINGVTPQDLQIIENNEFPVLLGDTPEYGVTQNTDEGKRKVLLSKPPYASSSTSTKFHPASNVPSFGQDELDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MNNSNEHRREE ----CCCCHHHHHHH | 38.29 | 30377154 | |
| 44 | Phosphorylation | MNREQEISLRAIKKG CCHHHHHHHHHHHCC | 15.85 | 23749301 | |
| 54 | Phosphorylation | AIKKGIYTDGGETDN HHHCCCCCCCCCCCC | 26.67 | 28889911 | |
| 59 | Phosphorylation | IYTDGGETDNYDMDK CCCCCCCCCCCCCCC | 32.59 | 24961812 | |
| 62 | Phosphorylation | DGGETDNYDMDKEND CCCCCCCCCCCCCCH | 18.56 | 21440633 | |
| 70 | Phosphorylation | DMDKENDSAYEMFKK CCCCCCHHHHHHHHH | 44.31 | 21440633 | |
| 103 | Phosphorylation | IEDNGQETDGYSDED CCCCCEECCCCCCCC | 27.17 | 21551504 | |
| 106 | Phosphorylation | NGQETDGYSDEDYTD CCEECCCCCCCCCCC | 18.76 | 21551504 | |
| 107 | Phosphorylation | GQETDGYSDEDYTDE CEECCCCCCCCCCCH | 39.80 | 28889911 | |
| 112 | Phosphorylation | GYSDEDYTDEADKSF CCCCCCCCCHHHHHH | 39.42 | 21551504 | |
| 147 | Acetylation | LESSGEAKKLKWRTY HHCCCCHHHHCEEHH | 55.10 | 22593213 | |
| 148 | Acetylation | ESSGEAKKLKWRTYI HCCCCHHHHCEEHHH | 63.45 | 22593213 | |
| 150 | Acetylation | SGEAKKLKWRTYIFY CCCHHHHCEEHHHHH | 43.43 | 22593213 | |
| 196 | Phosphorylation | SSPGKSFSNLQKQVN CCCCCCHHHHHHHHH | 43.66 | 30377154 | |
| 218 | Phosphorylation | KRDEKHSSELDKTVK HCHHHCHHHHHHHHH | 41.73 | 27017623 | |
| 233 | Acetylation | IIVSQFEKNIKRLLP HHHHHHHHHHHHHCC | 66.32 | 24489116 | |
| 557 | Acetylation | KRDRNYIKIAKFEYR CCCCCCEEEEEEEEE | 26.67 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MPS3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPS3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPS3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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