FYV6_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FYV6_YEAST
• UniProt AC: P53913
• Protein Name: Protein FYV6
• Gene Name: FYV6
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 173
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. Promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase..
• Protein Sequence: MSSTSDNNANSAREKKPLKFVSEGVGNVEAQRIREQVEQKKYEAEYKRKTRKSLRDQLRSNAISKQKQYNGLVRDRESFTRLSKEDLEFYQKSKNELLKKEKELNNYLDVKAINFEKKKKALLMENDSTTNTEKYLETGTSLGSKTQIKGVKTSSPKPKIKVSIKKLGRKLEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSTSDNNA ------CCCCCCCCC	42.18	22814378
16	Acetylation	ANSAREKKPLKFVSE CCCHHHCCCCCHHHC	51.32	24489116
19	Acetylation	AREKKPLKFVSEGVG HHHCCCCCHHHCCCC	52.85	24489116
41	Acetylation	REQVEQKKYEAEYKR HHHHHHHHHHHHHHH	48.28	25381059
53	Phosphorylation	YKRKTRKSLRDQLRS HHHHHHHHHHHHHHH	25.91	19823750
60	Phosphorylation	SLRDQLRSNAISKQK HHHHHHHHHHHHHHH	38.92	19823750
64	Phosphorylation	QLRSNAISKQKQYNG HHHHHHHHHHHHHCC	26.99	19823750
78	Phosphorylation	GLVRDRESFTRLSKE CCCCCHHHHHHCCHH	32.58	30377154
84	Acetylation	ESFTRLSKEDLEFYQ HHHHHCCHHHHHHHH	60.89	25381059
135	Phosphorylation	STTNTEKYLETGTSL CCCCHHHHHCCCCCC	11.98	22369663
138	Phosphorylation	NTEKYLETGTSLGSK CHHHHHCCCCCCCCC	43.07	22369663
140	Phosphorylation	EKYLETGTSLGSKTQ HHHHCCCCCCCCCCE	28.35	22369663
141	Phosphorylation	KYLETGTSLGSKTQI HHHCCCCCCCCCCEE	31.88	21440633
144	Phosphorylation	ETGTSLGSKTQIKGV CCCCCCCCCCEEECC	37.51	22369663
155	Phosphorylation	IKGVKTSSPKPKIKV EECCCCCCCCCCCEE	42.02	27214570
165	Acetylation	PKIKVSIKKLGRKLE CCCEEEHHHHHHHHC	34.14	25381059
166	Acetylation	KIKVSIKKLGRKLEN CCEEEHHHHHHHHCC	55.28	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FYV6_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FYV6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FYV6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIR4_YEAST	RNR4	genetic	18400565

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.