| UniProt ID | LCF3_YEAST | |
|---|---|---|
| UniProt AC | P39002 | |
| Protein Name | Long-chain-fatty-acid--CoA ligase 3 | |
| Gene Name | FAA3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 694 | |
| Subcellular Localization | ||
| Protein Description | Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10.. | |
| Protein Sequence | MSEQHSVAVGKAANEHETAPRRNVRVKKRPLIRPLNSSASTLYEFALECFNKGGKRDGMAWRDVIEIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPNGEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLLAKMIVPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDEVKLHPPEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAHIFELVFEFEAFYWNGILGYGSVKTLTNTSTRNCKGDLVEFKPTIMIGVAAVWETVRKAILEKISDLTPVLQKIFWSAYSMKEKSVPCTGFLSRMVFKKVRQATGGHLKYIMNGGSAISIDAQKFFSIVLCPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAKNNQGELLLKGAPVCSEYYKNPIETAVSFTYDGWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEYIALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKALRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVYKENS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEQHSVAV ------CCHHHCHHH | 46.06 | 22814378 | |
| 2 | Phosphorylation | ------MSEQHSVAV ------CCHHHCHHH | 46.06 | 21126336 | |
| 340 | Phosphorylation | LGYGSVKTLTNTSTR CCCCEEEEHHCCCCC | 36.34 | 28889911 | |
| 342 | Phosphorylation | YGSVKTLTNTSTRNC CCEEEEHHCCCCCCC | 41.50 | 28889911 | |
| 344 | Phosphorylation | SVKTLTNTSTRNCKG EEEEHHCCCCCCCCC | 26.66 | 28889911 | |
| 345 | Phosphorylation | VKTLTNTSTRNCKGD EEEHHCCCCCCCCCC | 27.69 | 28889911 | |
| 346 | Phosphorylation | KTLTNTSTRNCKGDL EEHHCCCCCCCCCCE | 24.70 | 28889911 | |
| 419 | Phosphorylation | FKKVRQATGGHLKYI HHHHHHHCCCCEEEE | 35.04 | 25533186 | |
| 489 | Ubiquitination | TAKLVDVKDLGYYAK EEEEECHHHHCCEEE | 42.65 | 24961812 | |
| 489 | Acetylation | TAKLVDVKDLGYYAK EEEEECHHHHCCEEE | 42.65 | 24489116 | |
| 505 | Ubiquitination | NQGELLLKGAPVCSE CCCCEEECCCCCCHH | 53.66 | 23749301 | |
| 555 | Acetylation | DRRKNLVKTLNGEYI CCCCHHHHHHCCEEE | 50.92 | 24489116 | |
| 604 | Acetylation | PNPGPLSKFAVKLRI CCCCCHHHHHHHHEE | 45.05 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LCF3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LCF3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LCF3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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