KIME_YEAST - dbPTM
KIME_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIME_YEAST
UniProt AC P07277
Protein Name Mevalonate kinase {ECO:0000305}
Gene Name ERG12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 443
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.; RAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids..
Protein Sequence MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
64PhosphorylationISFNHKWSINDFNAI
CCCCCCCCCCCCCCC		19.1328889911
80AcetylationEDQVNSQKLAKAQQA
HHHHHHHHHHHHHHH		50.6724489116
251AcetylationTRIPRSTKDLVARVR
CCCCCCHHHHHHHHE		50.7625381059
339PhosphorylationLELIKNLSDDLRIGS
HHHHHCCCCCCEECC		38.1727017623
358PhosphorylationGAGGGGCSLTLLRRD
CCCCCCCEEEEEECC		27.8827017623
375AcetylationQEQIDSFKKKLQDDF
HHHHHHHHHHHHCCC		53.6124489116
375SuccinylationQEQIDSFKKKLQDDF
HHHHHHHHHHHHCCC		53.6123954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIME_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIME_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIME_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RIM1_YEASTRIM1genetic
20093466
XRS2_YEASTXRS2genetic
20093466
PT122_YEASTPET122genetic
20093466
MED5_YEASTNUT1genetic
20093466
ICE2_YEASTICE2genetic
20093466
PLMT_YEASTOPI3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
COX12_YEASTCOX12genetic
20093466
NST1_YEASTNST1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
YIG1_YEASTYIG1genetic
20093466
ELP4_YEASTELP4genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
DCOR_YEASTSPE1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
GPX3_YEASTHYR1genetic
21623372
DAL5_YEASTDAL5genetic
21623372
GSH1_YEASTGSH1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ALAT_YEASTALT2genetic
21623372
SPEE_YEASTSPE3genetic
21623372
TRPD_YEASTTRP4genetic
21623372
TNA1_YEASTTNA1genetic
21623372
MET8_YEASTMET8genetic
21623372
DHOM_YEASTHOM6genetic
21623372
ALN_YEASTDAL1genetic
21623372
SYSM_YEASTDIA4genetic
21623372
IDHC_YEASTIDP2genetic
21623372
THDH_YEASTILV1genetic
21623372
TPS2_YEASTTPS2genetic
21623372
KIME_YEASTERG12physical
22940862
SSB1_YEASTSSB1physical
22940862
KPC1_YEASTPKC1genetic
27708008
ALG14_YEASTALG14genetic
27708008
CALM_YEASTCMD1genetic
27708008
MED8_YEASTMED8genetic
27708008
SLU7_YEASTSLU7genetic
27708008
GPI19_YEASTGPI19genetic
27708008
COG3_YEASTCOG3genetic
27708008
HSF_YEASTHSF1genetic
27708008
TAF6_YEASTTAF6genetic
27708008
PGTB1_YEASTCDC43genetic
27708008
MED6_YEASTMED6genetic
27708008
PAN1_YEASTPAN1genetic
27708008
ERG27_YEASTERG27genetic
27708008
SEC59_YEASTSEC59genetic
27708008
GRPE_YEASTMGE1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
DPM1_YEASTDPM1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
TRPF_YEASTTRP1genetic
27708008
UPC2_YEASTUPC2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
MSN5_YEASTMSN5genetic
27708008
ERD1_YEASTERD1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
MED20_YEASTSRB2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
BCK1_YEASTBCK1genetic
27708008
CANB_YEASTCNB1genetic
27708008
ENV10_YEASTENV10genetic
27708008
ARV1_YEASTARV1genetic
27708008
MID2_YEASTMID2genetic
27708008
ORM2_YEASTORM2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
STI1_YEASTSTI1genetic
27708008
LGE1_YEASTLGE1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
RLM1_YEASTRLM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIME_YEAST

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Related Literatures of Post-Translational Modification

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