| UniProt ID | SPT5_YEAST | |
|---|---|---|
| UniProt AC | P27692 | |
| Protein Name | Transcription elongation factor SPT5 | |
| Gene Name | SPT5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1063 | |
| Subcellular Localization | Nucleus . Mitochondrion . | |
| Protein Description | The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.. | |
| Protein Sequence | MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKRGIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARFGSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVTITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVENAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGREVALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGITYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGGKTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWGGASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGGASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDNSDTNV ------CCCCCCCCC | 57.72 | 28889911 | |
| 5 | Phosphorylation | ---MSDNSDTNVSMQ ---CCCCCCCCCCCC | 51.29 | 28889911 | |
| 7 | Phosphorylation | -MSDNSDTNVSMQDH -CCCCCCCCCCCCCC | 37.02 | 24961812 | |
| 10 | Phosphorylation | DNSDTNVSMQDHDQQ CCCCCCCCCCCCCCC | 16.88 | 27717283 | |
| 27 | Phosphorylation | DPVVVPQSTDTKDEN CCEECCCCCCCCCCC | 23.37 | 30377154 | |
| 28 | Phosphorylation | PVVVPQSTDTKDENT CEECCCCCCCCCCCC | 42.30 | 30377154 | |
| 35 | Phosphorylation | TDTKDENTSDKDTVD CCCCCCCCCCCCCCC | 35.93 | 25521595 | |
| 36 | Phosphorylation | DTKDENTSDKDTVDS CCCCCCCCCCCCCCC | 55.00 | 25521595 | |
| 40 | Phosphorylation | ENTSDKDTVDSGNVT CCCCCCCCCCCCCCC | 31.77 | 22890988 | |
| 43 | Phosphorylation | SDKDTVDSGNVTTTE CCCCCCCCCCCCCCC | 28.12 | 22890988 | |
| 47 | Phosphorylation | TVDSGNVTTTESTER CCCCCCCCCCCCCCC | 31.81 | 22890988 | |
| 48 | Phosphorylation | VDSGNVTTTESTERA CCCCCCCCCCCCCCC | 25.04 | 22890988 | |
| 49 | Phosphorylation | DSGNVTTTESTERAE CCCCCCCCCCCCCCC | 20.69 | 22890988 | |
| 51 | Phosphorylation | GNVTTTESTERAEST CCCCCCCCCCCCCCC | 33.21 | 22890988 | |
| 52 | Phosphorylation | NVTTTESTERAESTS CCCCCCCCCCCCCCC | 24.21 | 22890988 | |
| 57 | Phosphorylation | ESTERAESTSNIPPL CCCCCCCCCCCCCCC | 35.83 | 24909858 | |
| 58 | Phosphorylation | STERAESTSNIPPLD CCCCCCCCCCCCCCC | 19.80 | 19823750 | |
| 59 | Phosphorylation | TERAESTSNIPPLDG CCCCCCCCCCCCCCC | 41.88 | 29734811 | |
| 69 | Acetylation | PPLDGEEKEAKSEPQ CCCCCCHHCCCCCCC | 59.68 | 24489116 | |
| 69 | Ubiquitination | PPLDGEEKEAKSEPQ CCCCCCHHCCCCCCC | 59.68 | 23749301 | |
| 107 | Phosphorylation | DAQATLNTDSSEANE CHHHHCCCCCHHHHH | 40.13 | 19779198 | |
| 110 | Phosphorylation | ATLNTDSSEANEIVK HHCCCCCHHHHHHHH | 43.46 | 19779198 | |
| 133 | Phosphorylation | KRPREEDTKNSDGDT CCCCHHHCCCCCCCC | 35.09 | 17287358 | |
| 136 | Phosphorylation | REEDTKNSDGDTKDE CHHHCCCCCCCCCCC | 44.52 | 17287358 | |
| 188 | Phosphorylation | LDIEAEVSDDEDEDE CCEEEEECCCCCCCC | 30.74 | 23607784 | |
| 200 | Phosphorylation | EDEDEEDSELVREGF CCCCHHHHHHHHHHC | 35.79 | 29650682 | |
| 209 | Phosphorylation | LVREGFITHGDDEDD HHHHHCCCCCCCCCC | 19.97 | 22369663 | |
| 219 | Phosphorylation | DDEDDEASAPGARRD CCCCCCCCCCCCCHH | 32.71 | 22369663 | |
| 239 | Acetylation | QLDQDLNKTSEEDAQ HHHHHHHHCCHHHHH | 61.80 | 25381059 | |
| 241 | Phosphorylation | DQDLNKTSEEDAQRL HHHHHHCCHHHHHHH | 40.37 | 23749301 | |
| 262 | Acetylation | RYGRSSSKQYRAAAQ HHCCCCCHHHHHHHH | 53.98 | 25381059 | |
| 317 | Acetylation | NLDRAMGKKKLKILS CHHHHHCHHHEEEEE | 33.38 | 23572591 | |
| 318 | Acetylation | LDRAMGKKKLKILSI HHHHHCHHHEEEEEE | 58.57 | 23572591 | |
| 321 | Acetylation | AMGKKKLKILSIFQR HHCHHHEEEEEEEEC | 50.94 | 24489116 | |
| 332 | Phosphorylation | IFQRDNYTGRIYIEA EEECCCCCCCEEEEC | 26.66 | 30377154 | |
| 341 | Ubiquitination | RIYIEAPKQSVIEKF CEEEECCCHHHHHHH | 63.35 | 23749301 | |
| 347 | Acetylation | PKQSVIEKFCNGVPD CCHHHHHHHHCCCCC | 44.06 | 24489116 | |
| 358 | Phosphorylation | GVPDIYISQKLLIPV CCCCEEEEEECEEEH | 12.32 | 28889911 | |
| 406 | Phosphorylation | LAMVDQISENNLEVM EEEEEECCCCCHHHH | 28.74 | 24930733 | |
| 424 | Acetylation | VPRLDYGKFDEIDPT CCCCCCCCCCCCCCC | 43.33 | 24489116 | |
| 466 | Ubiquitination | LDQANLYKRDDRHFT CCCCCCCCCCCCCCC | 53.14 | 23749301 | |
| 519 | Phosphorylation | EGAVDLTSVSQSIKK CCCCCCHHHHHHHHH | 27.37 | 30377154 | |
| 521 | Phosphorylation | AVDLTSVSQSIKKAQ CCCCHHHHHHHHHHH | 20.27 | 30377154 | |
| 523 | Phosphorylation | DLTSVSQSIKKAQAA CCHHHHHHHHHHHHC | 28.95 | 28889911 | |
| 525 | Acetylation | TSVSQSIKKAQAAKV HHHHHHHHHHHHCCC | 47.50 | 25381059 | |
| 571 | Phosphorylation | IKLNGFTTPLEFPIS EEECCCCCCCCCCHH | 24.50 | 21440633 | |
| 675 | Acetylation | KVIDETGKVSTITKG EEECCCCCEEEECCH | 40.19 | 24489116 | |
| 714 | Acetylation | IGDTIVEKVGSRREG ECCEEEHHCCCCCCC | 40.79 | 24489116 | |
| 757 | Phosphorylation | SNVEAVASKDNMLSN HHHHHHHCCCCCHHC | 33.66 | 25704821 | |
| 763 | Phosphorylation | ASKDNMLSNKMDLSK HCCCCCHHCCCCHHH | 24.52 | 28889911 | |
| 765 | Acetylation | KDNMLSNKMDLSKMN CCCCHHCCCCHHHCC | 30.34 | 25381059 | |
| 769 | Phosphorylation | LSNKMDLSKMNPEII HHCCCCHHHCCHHHH | 26.12 | 19779198 | |
| 770 | Acetylation | SNKMDLSKMNPEIIS HCCCCHHHCCHHHHH | 50.41 | 24489116 | |
| 778 | Acetylation | MNPEIISKMGPPSSK CCHHHHHHCCCCCCC | 37.15 | 24489116 | |
| 785 | Ubiquitination | KMGPPSSKTFQQPIQ HCCCCCCCCCCCCCC | 58.66 | 23749301 | |
| 785 | Acetylation | KMGPPSSKTFQQPIQ HCCCCCCCCCCCCCC | 58.66 | 24489116 | |
| 786 | Phosphorylation | MGPPSSKTFQQPIQS CCCCCCCCCCCCCCC | 28.73 | 28889911 | |
| 803 | Acetylation | GREVALGKTVRIRSA CCEEECCCEEEEECC | 44.70 | 22865919 | |
| 813 | Acetylation | RIRSAGYKGQLGIVK EEECCCCCCEEEEEE | 38.98 | 24489116 | |
| 820 | Acetylation | KGQLGIVKDVNGDKA CCEEEEEECCCCCEE | 54.78 | 24489116 | |
| 842 | Acetylation | NKHITIDKHKLTYYN CCCEEEEECCCEEEC | 38.50 | 25381059 | |
| 901 | Phosphorylation | AATSSGLSGGMTPGW HHHCCCCCCCCCCCC | 36.50 | 27017623 | |
| 905 | Phosphorylation | SGLSGGMTPGWSSFD CCCCCCCCCCCCCCC | 23.17 | 30377154 | |
| 909 | Phosphorylation | GGMTPGWSSFDGGKT CCCCCCCCCCCCCCC | 27.35 | 30377154 | |
| 910 | Phosphorylation | GMTPGWSSFDGGKTP CCCCCCCCCCCCCCC | 22.35 | 30377154 | |
| 931 | Phosphorylation | GSGGGGVSSWGGAST CCCCCCCCCCCCCCC | 24.53 | 28889911 | |
| 937 | Phosphorylation | VSSWGGASTWGGQGN CCCCCCCCCCCCCCC | 28.15 | 28889911 | |
| 948 | Phosphorylation | GQGNGGASAWGGAGG CCCCCCCCCCCCCCC | 28.03 | 28889911 | |
| 958 | Phosphorylation | GGAGGGASAWGGQGT CCCCCCCCCCCCCCC | 28.03 | 28889911 | |
| 969 | Phosphorylation | GQGTGATSTWGGASA CCCCCCCCCCCCCCC | 22.94 | 28889911 | |
| 975 | Phosphorylation | TSTWGGASAWGNKSS CCCCCCCCCCCCCCC | 28.03 | 28889911 | |
| 981 | Phosphorylation | ASAWGNKSSWGGAST CCCCCCCCCCCCCCC | 35.01 | 28889911 | |
| 987 | Phosphorylation | KSSWGGASTWASGGE CCCCCCCCCCCCCCC | 27.96 | 28889911 | |
| 988 | Phosphorylation | SSWGGASTWASGGES CCCCCCCCCCCCCCC | 25.23 | 27017623 | |
| 1000 | Phosphorylation | GESNGAMSTWGGTGD CCCCCCCCCCCCCCC | 22.07 | 28889911 | |
| 1009 | Phosphorylation | WGGTGDRSAYGGAST CCCCCCCCCCCCCCC | 30.49 | 22890988 | |
| 1011 | Phosphorylation | GTGDRSAYGGASTWG CCCCCCCCCCCCCCC | 19.83 | 22890988 | |
| 1015 | Phosphorylation | RSAYGGASTWGGNNN CCCCCCCCCCCCCCC | 28.15 | 22890988 | |
| 1016 | Phosphorylation | SAYGGASTWGGNNNN CCCCCCCCCCCCCCC | 27.82 | 19779198 | |
| 1025 | Phosphorylation | GGNNNNKSTRDGGAS CCCCCCCCCCCCCCC | 30.69 | 21440633 | |
| 1026 | Phosphorylation | GNNNNKSTRDGGASA CCCCCCCCCCCCCCC | 34.10 | 24961812 | |
| 1032 | Phosphorylation | STRDGGASAWGNQDD CCCCCCCCCCCCCCC | 28.03 | 25533186 | |
| 1043 | Phosphorylation | NQDDGNRSAWNNQGN CCCCCCCCCCCCCCC | 41.45 | 21551504 | |
| 1052 | Phosphorylation | WNNQGNKSNYGGNST CCCCCCCCCCCCCCC | 39.00 | 22890988 | |
| 1054 | Phosphorylation | NQGNKSNYGGNSTWG CCCCCCCCCCCCCCC | 33.24 | 22890988 | |
| 1058 | Phosphorylation | KSNYGGNSTWGGH-- CCCCCCCCCCCCC-- | 28.89 | 22890988 | |
| 1059 | Phosphorylation | SNYGGNSTWGGH--- CCCCCCCCCCCC--- | 31.93 | 22890988 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPT5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPT5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPT5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35; SER-36; SER-57 ANDSER-358, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-133 AND SER-136, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35, AND MASSSPECTROMETRY. | |
