| UniProt ID | BBC1_YEAST | |
|---|---|---|
| UniProt AC | P47068 | |
| Protein Name | Myosin tail region-interacting protein MTI1 | |
| Gene Name | BBC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1157 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, actin patch . Colocalizes with cortical actin patches. | |
| Protein Description | Involved in the regulation of actin cytoskeleton.. | |
| Protein Sequence | MSEPEVPFKVVAQFPYKSDYEDDLNFEKDQEIIVTSVEDAEWYFGEYQDSNGDVIEGIFPKSFVAVQGSEVGKEAESSPNTGSTEQRTIQPEVEQKDLPEPISPETKKETLSGPVPVPAATVPVPAATVPVPAATAVSAQVQHDSSSGNGERKVPMDSPKLKARLSMFNQDITEQVPLPKSTHLDLENIPVKKTIVADAPKYYVPPGIPTNDTSNLERKKSLKENEKKIVPEPINRAQVESGRIETENDQLKKDLPQMSLKERIALLQEQQRLQAAREEELLRKKAKLEQEHERSAVNKNEPYTETEEAEENEKTEPKPEFTPETEHNEEPQMELLAHKEITKTSREADEGTNDIEKEQFLDEYTKENQKVEESQADEARGENVAEESEIGYGHEDREGDNDEEKEEEDSEENRRAALRERMAKLSGASRFGAPVGFNPFGMASGVGNKPSEEPKKKQHKEKEEEEPEQLQELPRAIPVMPFVDPSSNPFFRKSNLSEKNQPTETKTLDPHATTEHEQKQEHGTHAYHNLAAVDNAHPEYSDHDSDEDTDDHEFEDANDGLRKHSMVEQAFQIGNNESENVNSGEKIYPQEPPISHRTAEVSHDIENSSQNTTGNVLPVSSPQTRVARNGSINSLTKSISGENRRKSINEYHDTVSTNSSALTETAQDISMAAPAAPVLSKVSHPEDKVPPHPVPSAPSAPPVPSAPSVPSAPPVPPAPPALSAPSVPPVPPVPPVSSAPPALSAPSIPPVPPTPPAPPAPPAPLALPKHNEVEEHVKSSAPLPPVSEEYHPMPNTAPPLPRAPPVPPATFEFDSEPTATHSHTAPSPPPHQNVTASTPSMMSTQQRVPTSVLSGAEKESRTLPPHVPSLTNRPVDSFHESDTTPKVASIRRSTTHDVGEISNNVKIEFNAQERWWINKSAPPAISNLKLNFLMEIDDHFISKRLHQKWVVRDFYFLFENYSQLRFSLTFNSTSPEKTVTTLQERFPSPVETQSARILDEYAQRFNAKVVEKSHSLINSHIGAKNFVSQIVSEFKDEVIQPIGARTFGATILSYKPEEGIEQLMKSLQKIKPGDILVIRKAKFEAHKKIGKNEIINVGMDSAAPYSSVVTDYDFTKNKFRVIENHEGKIIQNSYKLSHMKSGKLKVFRIVARGYVGW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | VAQFPYKSDYEDDLN EEECCCCCCCCCCCC | 39.31 | 24930733 | |
| 69 | Phosphorylation | SFVAVQGSEVGKEAE CEEEEECCCCCCCCC | 16.42 | 29136822 | |
| 73 | Acetylation | VQGSEVGKEAESSPN EECCCCCCCCCCCCC | 59.95 | 24489116 | |
| 73 | Ubiquitination | VQGSEVGKEAESSPN EECCCCCCCCCCCCC | 59.95 | 23749301 | |
| 77 | Phosphorylation | EVGKEAESSPNTGST CCCCCCCCCCCCCCC | 59.13 | 22369663 | |
| 78 | Phosphorylation | VGKEAESSPNTGSTE CCCCCCCCCCCCCCC | 17.42 | 22369663 | |
| 81 | Phosphorylation | EAESSPNTGSTEQRT CCCCCCCCCCCCCEE | 35.57 | 22369663 | |
| 83 | Phosphorylation | ESSPNTGSTEQRTIQ CCCCCCCCCCCEECC | 27.08 | 22369663 | |
| 84 | Phosphorylation | SSPNTGSTEQRTIQP CCCCCCCCCCEECCC | 37.17 | 22369663 | |
| 88 | Phosphorylation | TGSTEQRTIQPEVEQ CCCCCCEECCCCHHH | 24.53 | 20377248 | |
| 103 | Phosphorylation | KDLPEPISPETKKET CCCCCCCCHHCCCCC | 27.65 | 22369663 | |
| 106 | Phosphorylation | PEPISPETKKETLSG CCCCCHHCCCCCCCC | 51.29 | 22369663 | |
| 110 | Phosphorylation | SPETKKETLSGPVPV CHHCCCCCCCCCCCC | 34.79 | 19823750 | |
| 112 | Phosphorylation | ETKKETLSGPVPVPA HCCCCCCCCCCCCCC | 48.77 | 19823750 | |
| 121 | Phosphorylation | PVPVPAATVPVPAAT CCCCCCCCCCCCCCC | 27.70 | 19823750 | |
| 128 | Phosphorylation | TVPVPAATVPVPAAT CCCCCCCCCCCCCEE | 27.70 | 19823750 | |
| 135 | Phosphorylation | TVPVPAATAVSAQVQ CCCCCCEEEEEEEEE | 29.69 | 19823750 | |
| 138 | Phosphorylation | VPAATAVSAQVQHDS CCCEEEEEEEEECCC | 15.54 | 19823750 | |
| 145 | Phosphorylation | SAQVQHDSSSGNGER EEEEECCCCCCCCCC | 25.03 | 19823750 | |
| 146 | Phosphorylation | AQVQHDSSSGNGERK EEEECCCCCCCCCCC | 48.61 | 19823750 | |
| 147 | Phosphorylation | QVQHDSSSGNGERKV EEECCCCCCCCCCCC | 39.98 | 19823750 | |
| 158 | Phosphorylation | ERKVPMDSPKLKARL CCCCCCCCHHHHHHH | 20.06 | 22369663 | |
| 166 | Phosphorylation | PKLKARLSMFNQDIT HHHHHHHHHHCCCCH | 18.77 | 22369663 | |
| 173 | Phosphorylation | SMFNQDITEQVPLPK HHHCCCCHHCCCCCC | 28.75 | 22890988 | |
| 182 | Phosphorylation | QVPLPKSTHLDLENI CCCCCCCCCCCHHCC | 32.36 | 28889911 | |
| 201 | Acetylation | TIVADAPKYYVPPGI EEEECCCCCCCCCCC | 51.43 | 24489116 | |
| 210 | Phosphorylation | YVPPGIPTNDTSNLE CCCCCCCCCCCCCHH | 43.75 | 30377154 | |
| 213 | Phosphorylation | PGIPTNDTSNLERKK CCCCCCCCCCHHHHH | 22.91 | 21440633 | |
| 214 | Phosphorylation | GIPTNDTSNLERKKS CCCCCCCCCHHHHHH | 42.13 | 28889911 | |
| 221 | Phosphorylation | SNLERKKSLKENEKK CCHHHHHHHHHHHHH | 47.94 | 17287358 | |
| 252 | Acetylation | ETENDQLKKDLPQMS CCCCHHHHHHCCCCC | 38.31 | 25381059 | |
| 261 | Acetylation | DLPQMSLKERIALLQ HCCCCCHHHHHHHHH | 37.33 | 24489116 | |
| 303 | Phosphorylation | AVNKNEPYTETEEAE CCCCCCCCCCHHHHH | 15.84 | 25533186 | |
| 304 | Phosphorylation | VNKNEPYTETEEAEE CCCCCCCCCHHHHHH | 47.34 | 28889911 | |
| 315 | Phosphorylation | EAEENEKTEPKPEFT HHHHHCCCCCCCCCC | 51.87 | 21440633 | |
| 322 | Phosphorylation | TEPKPEFTPETEHNE CCCCCCCCCCCCCCC | 20.67 | 22369663 | |
| 325 | Phosphorylation | KPEFTPETEHNEEPQ CCCCCCCCCCCCCCC | 43.69 | 20377248 | |
| 344 | Phosphorylation | AHKEITKTSREADEG HCHHHHHHHHHHCCC | 25.11 | 24961812 | |
| 345 | Phosphorylation | HKEITKTSREADEGT CHHHHHHHHHHCCCC | 29.67 | 20377248 | |
| 352 | Phosphorylation | SREADEGTNDIEKEQ HHHHCCCCCHHHHHH | 27.89 | 21551504 | |
| 357 | Acetylation | EGTNDIEKEQFLDEY CCCCHHHHHHHHHHH | 58.09 | 24489116 | |
| 357 | Ubiquitination | EGTNDIEKEQFLDEY CCCCHHHHHHHHHHH | 58.09 | 23749301 | |
| 374 | Phosphorylation | ENQKVEESQADEARG HCHHHHHHHHHHHHC | 19.70 | 28889911 | |
| 388 | Phosphorylation | GENVAEESEIGYGHE CCCCHHHHCCCCCCC | 26.48 | 25704821 | |
| 410 | Phosphorylation | EEKEEEDSEENRRAA HHHHHHCCHHHHHHH | 50.52 | 28889911 | |
| 424 | Acetylation | ALRERMAKLSGASRF HHHHHHHHHHHHHHC | 33.57 | 25381059 | |
| 424 | Ubiquitination | ALRERMAKLSGASRF HHHHHHHHHHHHHHC | 33.57 | 23749301 | |
| 429 | Phosphorylation | MAKLSGASRFGAPVG HHHHHHHHHCCCCCC | 31.50 | 21551504 | |
| 462 | Acetylation | KKKQHKEKEEEEPEQ CHHHHHHHHHCCHHH | 75.20 | 24489116 | |
| 486 | Phosphorylation | VMPFVDPSSNPFFRK CCCCCCCCCCCCCCC | 37.98 | 30377154 | |
| 494 | Phosphorylation | SNPFFRKSNLSEKNQ CCCCCCCCCCCCCCC | 38.45 | 28889911 | |
| 497 | Phosphorylation | FFRKSNLSEKNQPTE CCCCCCCCCCCCCCC | 51.26 | 24909858 | |
| 499 | Ubiquitination | RKSNLSEKNQPTETK CCCCCCCCCCCCCCC | 58.46 | 23749301 | |
| 503 | Phosphorylation | LSEKNQPTETKTLDP CCCCCCCCCCCCCCC | 46.66 | 21440633 | |
| 513 | Phosphorylation | KTLDPHATTEHEQKQ CCCCCCCCCHHHHHH | 29.68 | 20377248 | |
| 514 | Phosphorylation | TLDPHATTEHEQKQE CCCCCCCCHHHHHHH | 35.81 | 21440633 | |
| 565 | Phosphorylation | NDGLRKHSMVEQAFQ CHHHHHHHHHHHHHH | 27.79 | 22369663 | |
| 578 | Phosphorylation | FQIGNNESENVNSGE HHCCCCCCCCCCCCC | 36.27 | 22890988 | |
| 583 | Phosphorylation | NESENVNSGEKIYPQ CCCCCCCCCCCCCCC | 44.01 | 22890988 | |
| 598 | Phosphorylation | EPPISHRTAEVSHDI CCCCCCCCEEEECCC | 23.03 | 22890988 | |
| 602 | Phosphorylation | SHRTAEVSHDIENSS CCCCEEEECCCCCCC | 13.62 | 22369663 | |
| 608 | Phosphorylation | VSHDIENSSQNTTGN EECCCCCCCCCCCCC | 22.10 | 22369663 | |
| 609 | Phosphorylation | SHDIENSSQNTTGNV ECCCCCCCCCCCCCE | 38.75 | 22369663 | |
| 612 | Phosphorylation | IENSSQNTTGNVLPV CCCCCCCCCCCEEEC | 28.57 | 22890988 | |
| 613 | Phosphorylation | ENSSQNTTGNVLPVS CCCCCCCCCCEEECC | 34.02 | 22890988 | |
| 620 | Phosphorylation | TGNVLPVSSPQTRVA CCCEEECCCCCCHHC | 34.07 | 22369663 | |
| 621 | Phosphorylation | GNVLPVSSPQTRVAR CCEEECCCCCCHHCC | 22.66 | 22369663 | |
| 624 | Phosphorylation | LPVSSPQTRVARNGS EECCCCCCHHCCCCC | 30.41 | 22369663 | |
| 631 | Phosphorylation | TRVARNGSINSLTKS CHHCCCCCHHHHCCC | 23.34 | 22369663 | |
| 634 | Phosphorylation | ARNGSINSLTKSISG CCCCCHHHHCCCCCC | 35.43 | 22369663 | |
| 636 | Phosphorylation | NGSINSLTKSISGEN CCCHHHHCCCCCCCC | 23.67 | 22369663 | |
| 638 | Phosphorylation | SINSLTKSISGENRR CHHHHCCCCCCCCHH | 19.42 | 17330950 | |
| 640 | Phosphorylation | NSLTKSISGENRRKS HHHCCCCCCCCHHHC | 47.33 | 25752575 | |
| 647 | Phosphorylation | SGENRRKSINEYHDT CCCCHHHCHHHCCCC | 28.91 | 19823750 | |
| 651 | Phosphorylation | RRKSINEYHDTVSTN HHHCHHHCCCCHHCC | 10.66 | 20377248 | |
| 654 | Phosphorylation | SINEYHDTVSTNSSA CHHHCCCCHHCCCHH | 11.75 | 20377248 | |
| 656 | Phosphorylation | NEYHDTVSTNSSALT HHCCCCHHCCCHHHH | 24.78 | 20377248 | |
| 657 | Phosphorylation | EYHDTVSTNSSALTE HCCCCHHCCCHHHHH | 34.48 | 20377248 | |
| 659 | Phosphorylation | HDTVSTNSSALTETA CCCHHCCCHHHHHHH | 19.65 | 20377248 | |
| 660 | Phosphorylation | DTVSTNSSALTETAQ CCHHCCCHHHHHHHH | 29.39 | 20377248 | |
| 663 | Phosphorylation | STNSSALTETAQDIS HCCCHHHHHHHHHHH | 30.89 | 20377248 | |
| 665 | Phosphorylation | NSSALTETAQDISMA CCHHHHHHHHHHHHH | 25.12 | 20377248 | |
| 670 | Phosphorylation | TETAQDISMAAPAAP HHHHHHHHHHCCCCC | 15.62 | 20377248 | |
| 680 | Phosphorylation | APAAPVLSKVSHPED CCCCCCCCCCCCCCC | 31.11 | 24909858 | |
| 778 | Acetylation | NEVEEHVKSSAPLPP CCHHHHHHHCCCCCC | 40.37 | 24489116 | |
| 822 | Phosphorylation | SEPTATHSHTAPSPP CCCCCCCCCCCCCCC | 20.41 | 19779198 | |
| 835 | Phosphorylation | PPPHQNVTASTPSMM CCCCCCCCCCCCCCC | 23.57 | 19779198 | |
| 838 | Phosphorylation | HQNVTASTPSMMSTQ CCCCCCCCCCCCCCC | 19.54 | 21440633 | |
| 850 | Phosphorylation | STQQRVPTSVLSGAE CCCCCCCHHHHCCCH | 28.72 | 28152593 | |
| 851 | Phosphorylation | TQQRVPTSVLSGAEK CCCCCCHHHHCCCHH | 18.26 | 30377154 | |
| 854 | Phosphorylation | RVPTSVLSGAEKESR CCCHHHHCCCHHCCC | 33.53 | 22369663 | |
| 858 | Acetylation | SVLSGAEKESRTLPP HHHCCCHHCCCCCCC | 61.53 | 24489116 | |
| 858 | Ubiquitination | SVLSGAEKESRTLPP HHHCCCHHCCCCCCC | 61.53 | 23749301 | |
| 877 | Phosphorylation | LTNRPVDSFHESDTT CCCCCCCCCCCCCCC | 28.83 | 21440633 | |
| 881 | Phosphorylation | PVDSFHESDTTPKVA CCCCCCCCCCCCCEE | 31.52 | 21440633 | |
| 889 | Phosphorylation | DTTPKVASIRRSTTH CCCCCEEEEECCCCC | 21.44 | 20377248 | |
| 893 | Phosphorylation | KVASIRRSTTHDVGE CEEEEECCCCCCHHE | 28.01 | 22369663 | |
| 894 | Phosphorylation | VASIRRSTTHDVGEI EEEEECCCCCCHHEE | 26.74 | 22369663 | |
| 895 | Phosphorylation | ASIRRSTTHDVGEIS EEEECCCCCCHHEEC | 19.82 | 22369663 | |
| 902 | Phosphorylation | THDVGEISNNVKIEF CCCHHEECCCEEEEE | 20.32 | 22890988 | |
| 977 | Acetylation | FNSTSPEKTVTTLQE ECCCCCCCEEEEHHH | 52.24 | 24489116 | |
| 988 | Phosphorylation | TLQERFPSPVETQSA EHHHHCCCCCHHHHH | 38.58 | 23749301 | |
| 1012 | Ubiquitination | FNAKVVEKSHSLINS HCHHHHHHHHHHHHH | 41.69 | 22106047 | |
| 1046 | Phosphorylation | IQPIGARTFGATILS CCCCCHHHCCEEEEE | 26.36 | 29136822 | |
| 1050 | Phosphorylation | GARTFGATILSYKPE CHHHCCEEEEEECHH | 23.88 | 29136822 | |
| 1053 | Phosphorylation | TFGATILSYKPEEGI HCCEEEEEECHHHHH | 27.53 | 29136822 | |
| 1054 | Phosphorylation | FGATILSYKPEEGIE CCEEEEEECHHHHHH | 27.41 | 29136822 | |
| 1055 | Acetylation | GATILSYKPEEGIEQ CEEEEEECHHHHHHH | 42.45 | 24489116 | |
| 1066 | Phosphorylation | GIEQLMKSLQKIKPG HHHHHHHHHHCCCCC | 23.28 | 29136822 | |
| 1116 | Acetylation | VTDYDFTKNKFRVIE CCCCCCCCCEEEEEE | 59.12 | 24489116 | |
| 1128 | Acetylation | VIENHEGKIIQNSYK EEECCCCEEEECCEE | 33.38 | 24489116 | |
| 1135 | Acetylation | KIIQNSYKLSHMKSG EEEECCEEHHHCCCC | 43.25 | 24489116 | |
| 1140 | Acetylation | SYKLSHMKSGKLKVF CEEHHHCCCCCCEEE | 51.11 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BBC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BBC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BBC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81; SER-103; THR-106;SER-158; SER-166; SER-565; SER-602; SER-621; THR-624; SER-631;SER-634; SER-647; TYR-651; THR-654; THR-850; SER-854; SER-893; THR-894AND THR-895, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81; SER-103; SER-158;SER-166; SER-620; SER-893; THR-894 AND THR-895, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103; SER-158; SER-221;SER-889; THR-894 AND THR-895, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103; SER-158; SER-166;SER-565; SER-621; SER-631; SER-634; SER-638; THR-894 AND THR-895, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-621; SER-631;SER-638 AND THR-895, AND MASS SPECTROMETRY. | |
