GDE_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDE_YEAST
• UniProt AC: Q06625
• Protein Name: Glycogen debranching enzyme
• Gene Name: GDB1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1536
• Subcellular Localization: Mitochondrion . Cytoplasm .
• Protein Description: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation..
• Protein Sequence: MNRSLLLRLSDTGEPITSCSYGKGVLTLPPIPLPKDAPKDQPLYTVKLLVSAGSPVARDGLVWTNCPPDHNTPFKRDKFYKKIIHSSFHEDDCIDLNVYAPGSYCFYLSFRNDNEKLETTRKYYFVALPMLYINDQFLPLNSIALQSVVSKWLGSDWEPILSKIAAKNYNMVHFTPLQERGESNSPYSIYDQLQFDQEHFKSPEDVKNLVEHIHRDLNMLSLTDIVFNHTANNSPWLVEHPEAGYNHITAPHLISAIELDQELLNFSRNLKSWGYPTELKNIEDLFKIMDGIKVHVLGSLKLWEYYAVNVQTALRDIKAHWNDESNESYSFPENIKDISSDFVKLASFVKDNVTEPNFGTLGERNSNRINVPKFIQLLKLINDGGSDDSESSLATAQNILNEVNLPLYREYDDDVSEILEQLFNRIKYLRLDDGGPKQGPVTVDVPLTEPYFTRFKGKDGTDYALANNGWIWNGNPLVDFASQNSRAYLRREVIVWGDCVKLRYGKSPEDSPYLWERMSKYIEMNAKIFDGFRIDNCHSTPIHVGEYFLDLARKYNPNLYVVAELFSGSETLDCLFVERLGISSLIREAMQAWSEEELSRLVHKHGGRPIGSYKFVPMDDFSYPADINLNEEHCFNDSNDNSIRCVSEIMIPKILTATPPHALFMDCTHDNETPFEKRTVEDTLPNAALVALCSSAIGSVYGYDEIFPHLLNLVTEKRHYDISTPTGSPSIGITKVKATLNSIRTSIGEKAYDIEDSEMHVHHQGQYITFHRMDVKSGKGWYLIARMKFSDNDDPNETLPPVVLNQSTCSLRFSYALERVGDEIPNDDKFIKGIPTKLKELEGFDISYDDSKKISTIKLPNEFPQGSIAIFETQQNGVDESLDHFIRSGALKATSSLTLESINSVLYRSEPEEYDVSAGEGGAYIIPNFGKPVYCGLQGWVSVLRKIVFYNDLAHPLSANLRNGHWALDYTISRLNYYSDEAGINEVQNWLRSRFDRVKKLPSYLVPSYFALIIGILYGCCRLKAIQLMSRNIGKSTLFVQSLSMTSIQMVSRMKSTSILPGENVPSMAAGLPHFSVNYMRCWGRDVFISLRGMLLTTGRFDEAKAHILAFAKTLKHGLIPNLLDAGRNPRYNARDAAWFFLQAVQDYVYIVPDGEKILQEQVTRRFPLDDTYIPVDDPRAFSYSSTLEEIIYEILSRHAKGIKFREANAGPNLDRVMTDKGFNVEIHVDWSTGLIHGGSQYNCGTWMDKMGESEKAGSVGIPGTPRDGAAIEINGLLKSALRFVIELKNKGLFKFSDVETQDGGRIDFTEWNQLLQDNFEKRYYVPEDPSQDADYDVSAKLGVNRRGIYRDLYKSGKPYEDYQLRPNFAIAMTVAPELFVPEHAIKAITIADEVLRGPVGMRTLDPSDYNYRPYYNNGEDSDDFATSKGRNYHQGPEWVWLYGYFLRAFHHFHFKTSPRCQNAAKEKPSSYLYQQLYYRLKGHRKWIFESVWAGLTELTNKDGEVCNDSSPTQAWSSACLLDLFYDLWDAYEDDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RSLLLRLSDTGEPIT CCEEEEECCCCCCCC	27.05	27017623
20	Phosphorylation	GEPITSCSYGKGVLT CCCCCCCCCCCCEEE	36.37	27017623
21	Phosphorylation	EPITSCSYGKGVLTL CCCCCCCCCCCEEEC	27.47	27017623
45	Phosphorylation	PKDQPLYTVKLLVSA CCCCCCEEEEEECCC	20.88	28889911
123	Phosphorylation	KLETTRKYYFVALPM CCCCHHHEEEEEEEE	9.99	27017623
124	Phosphorylation	LETTRKYYFVALPML CCCHHHEEEEEEEEE	8.46	27017623
147	Phosphorylation	LNSIALQSVVSKWLG CCHHHHHHHHHHHHC	25.90	27017623
150	Phosphorylation	IALQSVVSKWLGSDW HHHHHHHHHHHCCCH	18.89	27017623
155	Phosphorylation	VVSKWLGSDWEPILS HHHHHHCCCHHHHHH	37.06	28889911
162	Phosphorylation	SDWEPILSKIAAKNY CCHHHHHHHHHHHCC	23.80	28889911
366	Phosphorylation	GTLGERNSNRINVPK CCCCCCCCCCCCHHH	33.43	27017623
720	Phosphorylation	LVTEKRHYDISTPTG HHHHCCCCCCCCCCC	21.00	24961812
723	Phosphorylation	EKRHYDISTPTGSPS HCCCCCCCCCCCCCC	25.99	24961812
724	Phosphorylation	KRHYDISTPTGSPSI CCCCCCCCCCCCCCC	25.79	24961812
726	Phosphorylation	HYDISTPTGSPSIGI CCCCCCCCCCCCCCC	50.83	24961812
728	Phosphorylation	DISTPTGSPSIGITK CCCCCCCCCCCCCCH	20.25	24961812
848	Phosphorylation	LEGFDISYDDSKKIS HCCCCCCCCCCCCEE	24.89	19779198
1256	Ubiquitination	DKMGESEKAGSVGIP HHCCCCCCCCCCCCC	68.29	23749301
1259	Phosphorylation	GESEKAGSVGIPGTP CCCCCCCCCCCCCCC	23.25	22369663
1265	Phosphorylation	GSVGIPGTPRDGAAI CCCCCCCCCCCCCEE	15.14	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDE_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDE_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDE_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYO1_YEAST	MYO1	physical	16554755
CYPC_YEAST	CPR3	physical	16554755
IGD1_YEAST	IGD1	physical	11283351
ARGJ_YEAST	ARG7	genetic	21623372
IGD1_YEAST	IGD1	physical	21585652
PHB2_YEAST	PHB2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, AND MASSSPECTROMETRY.
PubMed: 17761666