IF5A2_YEAST - dbPTM
IF5A2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF5A2_YEAST
UniProt AC P19211
Protein Name Eukaryotic translation initiation factor 5A-2
Gene Name ANB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 157
Subcellular Localization Cytoplasm. Concentrates in the perinuclear region.
Protein Description mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell (By similarity)..
Protein Sequence MSDEEHTFENADAGASATYPMQCSALRKNGFVVIKGRPCKIVDMSTSKTGKHGHAKVHLVTLDIFTGKKLEDLSPSTHNLEVPFVKRSEYQLLDIDDGYLSLMTMDGETKDDVKAPEGELGDSMQAAFDEGKDLMVTIISAMGEEAAISFKEAPRSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDEEHTFE
------CCCCCCCCC		54.4522369663
2Acetylation------MSDEEHTFE
------CCCCCCCCC		54.45-
7Phosphorylation-MSDEEHTFENADAG
-CCCCCCCCCCCCCC		35.6022369663
16PhosphorylationENADAGASATYPMQC
CCCCCCCCCCCCEEC		21.8922369663
18PhosphorylationADAGASATYPMQCSA
CCCCCCCCCCEECCH		26.1822369663
19PhosphorylationDAGASATYPMQCSAL
CCCCCCCCCEECCHH		9.0922369663
24PhosphorylationATYPMQCSALRKNGF
CCCCEECCHHHCCCE		17.2822369663
28AcetylationMQCSALRKNGFVVIK
EECCHHHCCCEEEEC		63.3722865919
28UbiquitinationMQCSALRKNGFVVIK
EECCHHHCCCEEEEC		63.3723749301
45PhosphorylationPCKIVDMSTSKTGKH
EEEEEECCCCCCCCC		25.6822369663
46PhosphorylationCKIVDMSTSKTGKHG
EEEEECCCCCCCCCC		27.8322369663
47PhosphorylationKIVDMSTSKTGKHGH
EEEECCCCCCCCCCC		22.4022369663
51HypusineMSTSKTGKHGHAKVH
CCCCCCCCCCCEEEE		52.20-
51OtherMSTSKTGKHGHAKVH
CCCCCCCCCCCEEEE		52.201903841
69AcetylationLDIFTGKKLEDLSPS
EECCCCCCHHHCCCC		59.4625381059
74PhosphorylationGKKLEDLSPSTHNLE
CCCHHHCCCCCCCCC		29.1817330950
88PhosphorylationEVPFVKRSEYQLLDI
CCCCCCCCCCEEEEC		34.6328889911
90PhosphorylationPFVKRSEYQLLDIDD
CCCCCCCCEEEECCC		13.0028889911
104PhosphorylationDGYLSLMTMDGETKD
CCEEEEEEECCCCCC		19.8728889911
149PhosphorylationMGEEAAISFKEAPRS
HCHHHEEECCCCCCC		26.0727214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF5A2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF5A2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF5A2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF5A1_YEASTHYP2genetic
1903841
IF5A1_YEASTHYP2physical
16554755
PFD6_YEASTYKE2genetic
19061648
RRP8_YEASTRRP8genetic
19061648
MRH4_YEASTMRH4genetic
19061648
EAF6_YEASTEAF6genetic
19061648
PFD5_YEASTGIM5genetic
19061648
PIH1_YEASTPIH1genetic
19061648
IF2G_YEASTGCD11genetic
19061648
BBP_YEASTMSL5genetic
19061648
NRP1_YEASTNRP1genetic
19061648
RPA49_YEASTRPA49genetic
19061648
CSL4_YEASTCSL4genetic
19061648
DHYS_YEASTDYS1physical
18719252
RPB1_YEASTRPO21genetic
27708008
RRP1_YEASTRRP1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
ACT_YEASTACT1genetic
27708008
SSL1_YEASTSSL1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
HRP1_YEASTHRP1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
SMP3_YEASTSMP3genetic
27708008
RPB2_YEASTRPB2genetic
27708008
MED4_YEASTMED4genetic
27708008
TF2B_YEASTSUA7genetic
27708008
RL36A_YEASTRPL36Agenetic
29158977
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF5A2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.

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