| UniProt ID | DHYS_YEAST | |
|---|---|---|
| UniProt AC | P38791 | |
| Protein Name | Deoxyhypusine synthase | |
| Gene Name | DYS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 387 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.. | |
| Protein Sequence | MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDINEKLP ------CCHHHHHHH | 47.39 | 22369663 | |
| 7 | Ubiquitination | -MSDINEKLPELLQD -CCHHHHHHHHHHHH | 65.93 | 24961812 | |
| 18 | Ubiquitination | LLQDAVLKASVPIPD HHHHHHHHCCCCCCC | 31.83 | 24961812 | |
| 29 | Acetylation | PIPDDFVKVQGIDYS CCCCCCEEECCCCCC | 28.91 | 24489116 | |
| 37 | Acetylation | VQGIDYSKPEATNMR ECCCCCCCCCCCCCC | 40.42 | 24489116 | |
| 78 | Acetylation | SMRSWRGKHIDELDD HHHHHCCCCHHHCCH | 28.90 | 22865919 | |
| 88 | Acetylation | DELDDHEKKGCFDEE HHCCHHCCCCCCCCC | 51.55 | 24489116 | |
| 89 | Ubiquitination | ELDDHEKKGCFDEEG HCCHHCCCCCCCCCC | 58.91 | 23749301 | |
| 100 | Phosphorylation | DEEGYQKTTIFMGYT CCCCCCEEEEEEEEC | 15.03 | 28889911 | |
| 106 | Phosphorylation | KTTIFMGYTSNLISS EEEEEEEECHHHHHH | 8.66 | 28889911 | |
| 107 | Phosphorylation | TTIFMGYTSNLISSG EEEEEEECHHHHHHC | 12.86 | 28889911 | |
| 157 | Ubiquitination | YLGEFALKGKSLRDQ HHHHHHHCCCCHHHC | 61.94 | 23749301 | |
| 157 | Acetylation | YLGEFALKGKSLRDQ HHHHHHHCCCCHHHC | 61.94 | 24489116 | |
| 159 | Ubiquitination | GEFALKGKSLRDQGM HHHHHCCCCHHHCCC | 44.74 | 22817900 | |
| 202 | Acetylation | EEQDEYVKKHGADCL HHHHHHHHHHCHHHH | 37.84 | 25381059 | |
| 217 | Phosphorylation | EANQDVDSPIWTPSK HCCCCCCCCCCCHHH | 20.38 | 23749301 | |
| 231 | Acetylation | KMIDRFGKEINDESS HHHHHHCHHCCCHHC | 53.35 | 24489116 | |
| 245 | Acetylation | SVLYWAHKNKIPIFC CHHHEECCCCCCEEC | 52.79 | 24489116 | |
| 286 | Ubiquitination | DIVGDIRKINSMSMA EEECCHHHHCCCHHH | 46.72 | 23749301 | |
| 350 | Ubiquitination | DEAVSWGKIKAEAKS CCCCCHHHCCCCHHH | 34.47 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DHYS_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DHYS_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DHYS_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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