ECM33_YEAST - dbPTM
ECM33_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ECM33_YEAST
UniProt AC P38248
Protein Name Cell wall protein ECM33
Gene Name ECM33
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 429
Subcellular Localization Cell membrane
Lipid-anchor, GPI-anchor . Secreted, cell wall . Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Protein Description Required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall. Important for apical bud growth..
Protein Sequence MQFKNALTATAILSASALAANSTTSIPSSCSIGTSATATAQADLDKISGCSTIVGNLTITGDLGSAALASIQEIDGSLTIFNSSSLSSFSADSIKKITGDLNMQELIILTSASFGSLQEVDSINMVTLPAISTFSTDLQNANNIIVSDTTLESVEGFSTLKKVNVFNINNNRYLNSFQSSLESVSDSLQFSSNGDNTTLAFDNLVWANNITLRDVNSISFGSLQTVNASLGFINNTLPSLNLTQLSKVGQSLSIVSNDELSKAAFSNLTTVGGGFIIANNTQLKVIDGFNKVQTVGGAIEVTGNFSTLDLSSLKSVRGGANFDSSSSNFSCNALKKLQSNGAIQGDSFVCKNGATSTSVKLSSTSTESSKSSATSSASSSGDASNAQANVSASASSSSSSSKKSKGAAPELVPATSFMGVVAAVGVALL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21N-linked_GlycosylationSASALAANSTTSIPS
HHHHHHCCCCCCCCC		33.99-
56N-linked_GlycosylationGCSTIVGNLTITGDL
CCCEEEEEEEEECCC		24.10-
82N-linked_GlycosylationDGSLTIFNSSSLSSF
CCCEEEECCCCCCCC		36.81-
1622-HydroxyisobutyrylationEGFSTLKKVNVFNIN
CCCCCCEEEEEEECC		42.00-
196N-linked_GlycosylationQFSSNGDNTTLAFDN
CCCCCCCCCEEEECC		36.04-
209N-linked_GlycosylationDNLVWANNITLRDVN
CCEEEECCEEECCCC		22.37-
227N-linked_GlycosylationFGSLQTVNASLGFIN
CCCCEEEEHHHCCHH		27.48-
234N-linked_GlycosylationNASLGFINNTLPSLN
EHHHCCHHCCCCCCC		32.92-
241N-linked_GlycosylationNNTLPSLNLTQLSKV
HCCCCCCCHHHHHHH		45.43-
251PhosphorylationQLSKVGQSLSIVSND
HHHHHCCCEEEECCH		20.3928152593
267N-linked_GlycosylationLSKAAFSNLTTVGGG
HHHHHHCCCEEECCC		34.65-
279N-linked_GlycosylationGGGFIIANNTQLKVI
CCCEEECCCCEEEEE		41.49-
304N-linked_GlycosylationGAIEVTGNFSTLDLS
EEEEEECCCEEEEHH		20.52-
328N-linked_GlycosylationNFDSSSSNFSCNALK
CCCCCCCCCCHHHHH		34.50-
339PhosphorylationNALKKLQSNGAIQGD
HHHHHHHHCCCCCCC		47.9021440633
362PhosphorylationTSTSVKLSSTSTESS
EEEEEEEECCCCCCC		26.3319779198
363PhosphorylationSTSVKLSSTSTESSK
EEEEEEECCCCCCCC		36.4919779198
389N-linked_GlycosylationDASNAQANVSASASS
CCCCCEEEEEECCCC		19.05-
406GPI-anchorSSSKKSKGAAPELVP
CCCCCCCCCCCCCCC		33.78-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ECM33_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ECM33_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ECM33_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC3_YEASTCDC34genetic
11957109
PST1_YEASTPST1genetic
15583168
PMT2_YEASTPMT2genetic
20093466
DEP1_YEASTDEP1genetic
20093466
VPS8_YEASTVPS8genetic
20093466
SCS22_YEASTSCS22genetic
20093466
SEF1_YEASTSEF1genetic
20093466
SKT5_YEASTSKT5genetic
20093466
PIN4_YEASTPIN4genetic
20093466
EDE1_YEASTEDE1genetic
20093466
VPS10_YEASTPEP1genetic
20093466
GPT1_YEASTSCT1genetic
20093466
SLA1_YEASTSLA1genetic
20093466
SWD3_YEASTSWD3genetic
20093466
BEM1_YEASTBEM1genetic
20093466
SWC5_YEASTSWC5genetic
20093466
STE50_YEASTSTE50genetic
20093466
ERS1_YEASTERS1genetic
20093466
YD206_YEASTYDL206Wgenetic
20093466
PAR32_YEASTPAR32genetic
20093466
PMT1_YEASTPMT1genetic
20093466
THI3_YEASTTHI3genetic
20093466
MBP1_YEASTMBP1genetic
20093466
TRPF_YEASTTRP1genetic
20093466
YD056_YEASTYDR056Cgenetic
20093466
VPS41_YEASTVPS41genetic
20093466
NUM1_YEASTNUM1genetic
20093466
CWC15_YEASTCWC15genetic
20093466
UME6_YEASTUME6genetic
20093466
H2A1_YEASTHTA1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
PAM1_YEASTPAM1genetic
20093466
PMP3_YEASTPMP3genetic
20093466
SSD1_YEASTSSD1genetic
20093466
HNT2_YEASTHNT2genetic
20093466
GIC2_YEASTGIC2genetic
20093466
SUM1_YEASTSUM1genetic
20093466
PAL1_YEASTPAL1genetic
20093466
YPS7_YEASTYPS7genetic
20093466
TRPD_YEASTTRP4genetic
20093466
LCMT1_YEASTPPM1genetic
20093466
PPZ2_YEASTPPZ2genetic
20093466
VPS60_YEASTVPS60genetic
20093466
PUF6_YEASTPUF6genetic
20093466
AGE1_YEASTAGE1genetic
20093466
GET2_YEASTGET2genetic
20093466
TRPE_YEASTTRP2genetic
20093466
IES5_YEASTIES5genetic
20093466
SWI4_YEASTSWI4genetic
20093466
BEM2_YEASTBEM2genetic
20093466
BCK2_YEASTBCK2genetic
20093466
BUD27_YEASTBUD27genetic
20093466
IES1_YEASTIES1genetic
20093466
PUS3_YEASTDEG1genetic
20093466
UBP6_YEASTUBP6genetic
20093466
RTF1_YEASTRTF1genetic
20093466
CWC26_YEASTBUD13genetic
20093466
ATC1_YEASTPMR1genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
CWH41_YEASTCWH41genetic
20093466
GET1_YEASTGET1genetic
20093466
ORM1_YEASTORM1genetic
20093466
DBF2_YEASTDBF2genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
SMI1_YEASTSMI1genetic
20093466
SODM_YEASTSOD2genetic
20093466
SLT2_YEASTSLT2genetic
20093466
ARP1_YEASTARP1genetic
20093466
MTC6_YEASTMTC6genetic
20093466
ATG7_YEASTATG7genetic
20093466
CRG1_YEASTCRG1genetic
20093466
IMPX_YEASTIMP2genetic
20093466
CAPZB_YEASTCAP2genetic
20093466
RPE_YEASTRPE1genetic
20093466
BCK1_YEASTBCK1genetic
20093466
DPOD3_YEASTPOL32genetic
20093466
VPS55_YEASTVPS55genetic
20093466
HOC1_YEASTHOC1genetic
20093466
DOA1_YEASTDOA1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
CANB_YEASTCNB1genetic
20093466
HSL1_YEASTHSL1genetic
20093466
MTC2_YEASTMTC2genetic
20093466
ELM1_YEASTELM1genetic
20093466
MRT4_YEASTMRT4genetic
20093466
YKR18_YEASTYKR018Cgenetic
20093466
GPT2_YEASTGPT2genetic
20093466
YL054_YEASTYLL054Cgenetic
20093466
LDB18_YEASTLDB18genetic
20093466
VPS13_YEASTVPS13genetic
20093466
BRE2_YEASTBRE2genetic
20093466
ERG3_YEASTERG3genetic
20093466
EMP46_YEASTEMP46genetic
20093466
STM1_YEASTSTM1genetic
20093466
THI7_YEASTTHI7genetic
20093466
CHS5_YEASTCHS5genetic
20093466
VRP1_YEASTVRP1genetic
20093466
ROM2_YEASTROM2genetic
20093466
MSC1_YEASTMSC1genetic
20093466
NU188_YEASTNUP188genetic
20093466
VPS9_YEASTVPS9genetic
20093466
PRM6_YEASTPRM6genetic
20093466
VPS71_YEASTVPS71genetic
20093466
YMD8_YEASTYMD8genetic
20093466
TSA1_YEASTTSA1genetic
20093466
PPZ1_YEASTPPZ1genetic
20093466
CTF18_YEASTCTF18genetic
20093466
MYO5_YEASTMYO5genetic
20093466
ERG2_YEASTERG2genetic
20093466
HOR7_YEASTHOR7genetic
20093466
TPS3_YEASTTPS3genetic
20093466
SCS7_YEASTSCS7genetic
20093466
NGL2_YEASTNGL2genetic
20093466
UBP15_YEASTUBP15genetic
20093466
PFD4_YEASTGIM3genetic
20093466
RAS2_YEASTRAS2genetic
20093466
PHO23_YEASTPHO23genetic
20093466
SWS2_YEASTSWS2genetic
20093466
EOS1_YEASTEOS1genetic
20093466
RL9B_YEASTRPL9Bgenetic
20093466
MAS5_YEASTYDJ1genetic
20093466
YNF8_YEASTYNL058Cgenetic
20093466
SPO1_YEASTSPO1genetic
20093466
RCF2_YEASTRCF2genetic
20093466
ZRG17_YEASTZRG17genetic
20093466
SHE4_YEASTSHE4genetic
20093466
WHI2_YEASTWHI2genetic
20093466
VHS3_YEASTVHS3genetic
20093466
VPS5_YEASTVPS5genetic
20093466
VPS21_YEASTVPS21genetic
20093466
PTP2_YEASTPTP2genetic
20093466
RUD3_YEASTRUD3genetic
20093466
HRK1_YEASTHRK1genetic
20093466
CG12_YEASTCLN2genetic
20093466
TBCC_YEASTCIN2genetic
20093466
BEM4_YEASTBEM4genetic
20093466
ISU1_YEASTISU1genetic
20093466
MEI5_YEASTMEI5genetic
20093466
SYH1_YEASTSYH1genetic
20093466
RLM1_YEASTRLM1genetic
20093466
LEE1_YEASTLEE1genetic
20093466
REC8_YEASTREC8genetic
20093466
TIP41_YEASTTIP41genetic
20093466
THP3_YEASTTHP3genetic
20093466
BRR1_YEASTBRR1genetic
20093466
CHMU_YEASTARO7genetic
20093466
TKT1_YEASTTKL1genetic
20093466
CG22_YEASTCLB2genetic
20093466
KAR3_YEASTKAR3genetic
20093466
SKI3_YEASTSKI3genetic
20093466
HPA2_YEASTHPA2genetic
20093466
YPT31_YEASTYPT31genetic
20526336
GUP1_YEASTGUP1genetic
20526336
EDE1_YEASTEDE1genetic
20526336
SLT2_YEASTSLT2genetic
20526336
KRE1_YEASTKRE1genetic
23891562
CHS7_YEASTCHS7genetic
23891562
CHS6_YEASTCHS6genetic
23891562
CHS5_YEASTCHS5genetic
23891562
ALG6_YEASTALG6genetic
23891562
ALG8_YEASTALG8genetic
23891562
VAM6_YEASTVAM6genetic
23891562
VAM7_YEASTVAM7genetic
23891562
PLMT_YEASTOPI3genetic
23891562
VPS74_YEASTVPS74genetic
23891562
GET2_YEASTGET2genetic
23891562
GDA1_YEASTGDA1genetic
23891562
GLO3_YEASTGLO3genetic
23891562
ERV14_YEASTERV14genetic
23891562
TLG2_YEASTTLG2genetic
23891562
RUD3_YEASTRUD3genetic
23891562
ACE2_YEASTACE2genetic
23891562
CCW12_YEASTCCW12genetic
23891562
CLA4_YEASTCLA4genetic
23891562
ERG3_YEASTERG3genetic
23891562
ELO3_YEASTELO3genetic
23891562
PFD3_YEASTPAC10genetic
23891562
PFD4_YEASTGIM3genetic
23891562
PSB5_YEASTPRE2genetic
23891562
HSL1_YEASTHSL1genetic
22282571
BCK1_YEASTBCK1genetic
22282571
HRK1_YEASTHRK1genetic
22282571
ELM1_YEASTELM1genetic
22282571
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ECM33_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339, AND MASSSPECTROMETRY.

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