EMP46_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMP46_YEAST
• UniProt AC: Q12396
• Protein Name: Protein EMP46
• Gene Name: EMP46
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 444
• Subcellular Localization: Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing..
• Protein Sequence: MTTRKTASSLQLLGKITGTKAGTKQKKMNFINGLIWLYMCVWMVHGKVTQKDELKWNKGYSLPNLLEVTDQQKELSQWTLGDKVKLEEGRFVLTPGKNTKGSLWLKPEYSIKDAMTIEWTFRSFGFRGSTKGGLAFWLKQGNEGDSTELFGGSSKKFNGLMILLRLDDKLGESVTAYLNDGTKDLDIESSPYFASCLFQYQDSMVPSTLRLTYNPLDNHLLKLQMDNRVCFQTRKVKFMGSSPFRIGTSAINDASKESFEILKMKLYDGVIEDSLIPNVNPMGQPRVVTKVINSQTGEESFREKMPFSDKEESITSNELFEKMNKLEGKIMANDIDPLLRKMNKIVENERELIQRLRPLLDLKKTAISDDSFQDFLSMNANLDRLIKEQEKIRQDAKLYGKQTKGHDEIFSKISVWLALLIFIMITLAYYMFRINQDIKKVKLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Ubiquitination	AYLNDGTKDLDIESS ECCCCCCCCCCCCCC	62.92	19722269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMP46_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMP46_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMP46_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPG_YEAST	SEC21	physical	12134087
SEC23_YEAST	SEC23	physical	12134087
EMP47_YEAST	EMP47	physical	12857885
EMP47_YEAST	EMP47	physical	14627716
YPS1_YEAST	YPS1	genetic	16269340
MTC4_YEAST	MTC4	genetic	16269340
MKAR_YEAST	IFA38	physical	16093310
EMP46_YEAST	EMP46	physical	16093310
EMP46_YEAST	EMP46	physical	26447473
EMP47_YEAST	EMP47	physical	26447473
PP2C1_YEAST	PTC1	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
CSI1_YEAST	CSI1	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
CKS1_YEAST	CKS1	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
BCP1_YEAST	BCP1	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
GNA1_YEAST	GNA1	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
PRS8_YEAST	RPT6	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
BRL1_YEAST	BRL1	genetic	27708008
FDFT_YEAST	ERG9	genetic	27708008
MET30_YEAST	MET30	genetic	27708008
ARPC5_YEAST	ARC15	genetic	27708008
SWD2_YEAST	SWD2	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
TAF4_YEAST	TAF4	genetic	27708008
ROT1_YEAST	ROT1	genetic	27708008
LCB1_YEAST	LCB1	genetic	27708008
DPOA_YEAST	POL1	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
CLP1_YEAST	CLP1	genetic	27708008
RPA1_YEAST	RPA190	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
SNF5_YEAST	SNF5	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
MRS3_YEAST	MRS3	genetic	27708008
RAV1_YEAST	RAV1	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
MIC60_YEAST	MIC60	genetic	27708008
ELO3_YEAST	ELO3	genetic	27708008
PKR1_YEAST	PKR1	genetic	27708008
VPS27_YEAST	VPS27	genetic	27708008
SIN3_YEAST	SIN3	genetic	27708008
PMG3_YEAST	GPM3	genetic	27708008
PDR10_YEAST	PDR10	genetic	27708008
NCBP2_YEAST	CBC2	genetic	27708008
THI22_YEAST	THI22	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.