| UniProt ID | YPS1_YEAST | |
|---|---|---|
| UniProt AC | P32329 | |
| Protein Name | Aspartic proteinase 3 | |
| Gene Name | YPS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 569 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor . GPI-anchored plasma membrane protein (GPI-PMP), peripherally distributed over the entire cell surface. |
|
| Protein Description | Cleaves proteins C-terminally to mono- and paired-basic residues. Involved in the shedding of a subset of GPI-anchored plasma membrane proteins from the cell surface, including itself, GAS1 and MSB2. May also play a role in the maturation of GPI-mannoproteins associated with the cell wall. Can process the alpha-mating factor precursor. Required for cell wall integrity.. | |
| Protein Sequence | MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKPEVRLLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSNSMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPASEATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAVANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLNDSDAMHGTILFGAVDHSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKTLTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGGFHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYNTTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASATSTSSKRNVGDHIVPSLPLTLISLLFAFI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | N-linked_Glycosylation | EVGTPPQNVTVLVDT ECCCCCCCEEEEEEC | 36.88 | - | |
| 203 | N-linked_Glycosylation | GSSTFRSNNTYFSIS CCEEECCCCEEEEEE | 40.38 | - | |
| 232 | N-linked_Glycosylation | VLDLSDLNVTGLSFA EECHHHCCCCCEEEE | 34.00 | - | |
| 242 | N-linked_Glycosylation | GLSFAVANETNSTMG CEEEEEECCCCCCCE | 50.45 | - | |
| 245 | N-linked_Glycosylation | FAVANETNSTMGVLG EEEECCCCCCCEEEE | 29.33 | - | |
| 275 | Acetylation | SHSGKAYKYDNFPIV CCCCEEEEECCCCEE | 51.49 | 24489116 | |
| 299 | N-linked_Glycosylation | NTYSLYLNDSDAMHG CEEEEECCCCCCCCE | 32.93 | - | |
| 358 | N-linked_Glycosylation | ISDSGSSNKTLTTTK ECCCCCCCCEEEECC | 42.92 | - | |
| 480 | N-linked_Glycosylation | SMAQARYNTTSENIE EEEEHHHCCCCCCEE | 31.18 | - | |
| 522 | N-linked_Glycosylation | GGNIFTVNSSQTASF CCCEEEECCCCCEEE | 32.65 | - | |
| 532 | N-linked_Glycosylation | QTASFSGNLTTSTAS CCEEEECCEEEECCC | 32.77 | - | |
| 548 | GPI-anchor | TSTSSKRNVGDHIVP CCCCCCCCCCCCCCC | 45.95 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of YPS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YPS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YPS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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