GFD1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GFD1_YEAST
• UniProt AC: Q04839
• Protein Name: mRNA transport factor GFD1
• Gene Name: GFD1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 188
• Subcellular Localization: Cytoplasm . Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export..
• Protein Sequence: MPLESIWADAPDEEPIKKQKPSHKRSNNNKKNNNSRWSNESSSNNKKKDSVNKVKNNKGNHESKTKNKIKETLPREKKPPHSQGKISPVSESLAINPFSQKATEISPPPVSPSKMKTTKTQSKQDTASKMKLLKKKIEEQREILQKTHHKNQQQQVLMDFLNDEGSSNWVDDDEEELILQRLKTSLKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	KNNNSRWSNESSSNN CCCCCCCCCCCCCCC	29.61	28889911
82	Phosphorylation	REKKPPHSQGKISPV CCCCCCCCCCCCCCC	46.53	17330950
87	Phosphorylation	PHSQGKISPVSESLA CCCCCCCCCCCHHHC	23.80	22369663
90	Phosphorylation	QGKISPVSESLAINP CCCCCCCCHHHCCCC	25.50	17330950
92	Phosphorylation	KISPVSESLAINPFS CCCCCCHHHCCCCCC	18.65	29136822
99	Phosphorylation	SLAINPFSQKATEIS HHCCCCCCCCCCCCC	31.84	19823750
103	Phosphorylation	NPFSQKATEISPPPV CCCCCCCCCCCCCCC	40.67	28132839
106	Phosphorylation	SQKATEISPPPVSPS CCCCCCCCCCCCCHH	25.73	22369663
111	Phosphorylation	EISPPPVSPSKMKTT CCCCCCCCHHHCCCC	29.27	22369663
113	Phosphorylation	SPPPVSPSKMKTTKT CCCCCCHHHCCCCCC	37.56	25521595
128	Phosphorylation	QSKQDTASKMKLLKK CCCHHHHHHHHHHHH	35.06	27717283
184	Phosphorylation	LILQRLKTSLKI--- HHHHHHHHHCCC---	43.83	29650682

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GFD1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GFD1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GFD1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAB2_YEAST	NAB2	physical	10688190
DBP5_YEAST	DBP5	physical	10523319
GFD1_YEAST	GFD1	physical	10523319
GLE1_YEAST	GLE1	physical	15208322
DBP5_YEAST	DBP5	physical	15619606
ZDS1_YEAST	ZDS1	physical	15619606
ERF3_YEAST	SUP35	genetic	19061648
SA190_YEAST	SAP190	genetic	19061648
PRP19_YEAST	PRP19	genetic	19061648
PRP11_YEAST	PRP11	genetic	19061648
LRS4_YEAST	LRS4	genetic	19061648
CHD1_YEAST	CHD1	genetic	19061648
NAB2_YEAST	NAB2	physical	20463024
DBP5_YEAST	DBP5	genetic	21576265
CHK1_YEAST	CHK1	genetic	27708008
NPL4_YEAST	NPL4	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
IPK1_YEAST	IPK1	genetic	27708008
CP56_YEAST	DIT2	genetic	27708008
SKI8_YEAST	SKI8	genetic	27708008
IMP2_YEAST	IMP2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-106 AND SER-111,AND MASS SPECTROMETRY.
PubMed: 18407956

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-106 AND SER-111,AND MASS SPECTROMETRY.
PubMed: 17330950