| UniProt ID | MKC7_YEAST | |
|---|---|---|
| UniProt AC | P53379 | |
| Protein Name | Aspartic proteinase MKC7 | |
| Gene Name | MKC7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 596 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor . GPI-anchored plasma membrane protein (GPI-PMP). |
|
| Protein Description | Cleaves proteins C-terminally to the most C-terminal basic residue. Can process the alpha-mating factor precursor. Required for cell wall integrity.. | |
| Protein Sequence | MKLSVLTFVVDALLVCSSIVDAGVTDFPSLPSNEVYVKMNFQKKYGSSFENALDDTKGRTRLMTRDDDYELVELTNQNSFYSVELDIGTPPQKVTVLVDTGSSDLWVTGSDNPYCSTKKKDTTGSSFKQVNKDALASVVESVFTEISYDTTIVTSEATATFDSTASTSQLIDCATYGTFNTSKSSTFNSNNTEFSIAYGDTTFASGTWGHDQLSLNDLNITGLSFAVANETNSTVGVLGIGLPGLESTYSGVSLSSVQKSYTYNNFPMVLKNSGVIKSTAYSLFANDSDSKHGTILFGAVDHGKYAGDLYTIPIINTLQHRGYKDPIQFQVTLQGLGTSKGDKEDNLTTLTTTKIPVLLDSGTTISYMPTELVKMLADQVGATYSSAYGYYIMDCIKEMEEESSIIFDFGGFYLSNWLSDFQLVTDSRSNICILGIAPQSDPTIILGDNFLANTYVVYDLDNMEISMAQANFSDDGEYIEIIESAVPSALKAPGYSSTWSTYESIVSGGNMFSTAANSSISYFASTSHSATSSSSSKGQKTQTSTTALSISKSTSSTSSTGMLSPTSSSSTRKENGGHNLNPPFFARFITAIFHHI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | KMNFQKKYGSSFENA EEECHHHHCCCHHHH | 29.31 | 25533186 | |
| 180 | N-linked_Glycosylation | CATYGTFNTSKSSTF EEEECCEECCCCCCC | 43.19 | - | |
| 190 | N-linked_Glycosylation | KSSTFNSNNTEFSIA CCCCCCCCCCEEEEE | 61.62 | - | |
| 219 | N-linked_Glycosylation | QLSLNDLNITGLSFA CCCCCCCCCCEEEEE | 32.41 | - | |
| 229 | N-linked_Glycosylation | GLSFAVANETNSTVG EEEEEEECCCCCEEE | 50.45 | - | |
| 232 | N-linked_Glycosylation | FAVANETNSTVGVLG EEEECCCCCEEEEEE | 29.51 | - | |
| 278 | Phosphorylation | KNSGVIKSTAYSLFA ECCCCEEEEEEHHHC | 13.72 | 19779198 | |
| 279 | Phosphorylation | NSGVIKSTAYSLFAN CCCCEEEEEEHHHCC | 25.31 | 19779198 | |
| 286 | N-linked_Glycosylation | TAYSLFANDSDSKHG EEEHHHCCCCCCCCC | 41.82 | - | |
| 346 | N-linked_Glycosylation | SKGDKEDNLTTLTTT CCCCCCCCEEEEEEC | 40.14 | - | |
| 471 | N-linked_Glycosylation | EISMAQANFSDDGEY EEEEEEECCCCCCCC | 25.52 | - | |
| 517 | N-linked_Glycosylation | NMFSTAANSSISYFA CCCCCCCCCCCEEEE | 33.55 | - | |
| 541 | Phosphorylation | SSSKGQKTQTSTTAL CCCCCCCCEEECEEE | 29.23 | 27017623 | |
| 543 | Phosphorylation | SKGQKTQTSTTALSI CCCCCCEEECEEEEE | 33.02 | 28889911 | |
| 554 | Phosphorylation | ALSISKSTSSTSSTG EEEEECCCCCCCCCC | 30.36 | 28889911 | |
| 557 | Phosphorylation | ISKSTSSTSSTGMLS EECCCCCCCCCCEEC | 26.85 | 19779198 | |
| 569 | Phosphorylation | MLSPTSSSSTRKENG EECCCCCCCCCCCCC | 35.18 | 19779198 | |
| 570 | Phosphorylation | LSPTSSSSTRKENGG ECCCCCCCCCCCCCC | 33.89 | 28889911 | |
| 571 | Phosphorylation | SPTSSSSTRKENGGH CCCCCCCCCCCCCCC | 47.94 | 28889911 | |
| 575 | GPI-anchor | SSSTRKENGGHNLNP CCCCCCCCCCCCCCH | 65.86 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MKC7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MKC7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MKC7_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KEX2_YEAST | KEX2 | genetic | 7479877 | |
| YPS1_YEAST | YPS1 | genetic | 7479877 | |
| YPS7_YEAST | YPS7 | genetic | 16087741 | |
| YPS1_YEAST | YPS1 | genetic | 18591427 | |
| YPS3_YEAST | YPS3 | genetic | 20599573 | |
| TRS85_YEAST | TRS85 | genetic | 19325107 | |
| SEC22_YEAST | SEC22 | genetic | 19325107 | |
| BPH1_YEAST | BPH1 | genetic | 23891562 | |
| FABG_YEAST | OAR1 | genetic | 27708008 | |
| UBA3_YEAST | UBA3 | genetic | 27708008 | |
| MSI1_YEAST | MSI1 | genetic | 27708008 | |
| HPC2_YEAST | HPC2 | genetic | 27708008 | |
| SWC5_YEAST | SWC5 | genetic | 27708008 | |
| RS14A_YEAST | RPS14A | genetic | 27708008 | |
| RL13A_YEAST | RPL13A | genetic | 27708008 | |
| ACA1_YEAST | ACA1 | genetic | 27708008 | |
| MAG_YEAST | MAG1 | genetic | 27708008 | |
| MSH4_YEAST | MSH4 | genetic | 27708008 | |
| SKN1_YEAST | SKN1 | genetic | 27708008 | |
| TBP7_YEAST | YTA7 | genetic | 27708008 | |
| YOR1_YEAST | YOR1 | genetic | 27708008 | |
| RL17B_YEAST | RPL17B | genetic | 27708008 | |
| PTK2_YEAST | PTK2 | genetic | 27708008 | |
| MOG1_YEAST | MOG1 | genetic | 27708008 | |
| CTK1_YEAST | CTK1 | genetic | 27708008 | |
| DBP7_YEAST | DBP7 | genetic | 27708008 | |
| FRA1_YEAST | FRA1 | genetic | 27708008 | |
| UBI4P_YEAST | UBI4 | genetic | 27708008 | |
| UBP8_YEAST | UBP8 | genetic | 27708008 | |
| LEO1_YEAST | LEO1 | genetic | 27708008 | |
| MED1_YEAST | MED1 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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