| UniProt ID | ARX1_YEAST | |
|---|---|---|
| UniProt AC | Q03862 | |
| Protein Name | Probable metalloprotease ARX1 | |
| Gene Name | ARX1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 593 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.. | |
| Protein Sequence | MALAISHEDTQILLKDKNILQESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYKNKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKITLGVHIDGYTSEVSHTMVIYPVDETKPILQPTGPLLGGKADAVAAAHIAMETVVALLACALTPEKLPASLGGTSSGITGQLIRTIVDTIARSYNCGVVPGSRVRRIRRFLAGQNEGIVAEREYKGVVWTESHQEADLLSNTDAKDLTVVDRGQSTPFTNVSAIPSDDFVVQSGEVYLIDLKMASLEHCTKKGLVTLETVDSYTGKSHKAGELIARPGAYVRDFAQTHILKLKTSRQLLTKIDKQGVYPFKLSHLSSNFPFVHENEEELQSLKKDLKSFRLGMSEISNNYLCVESPIQIARWVPWDHILKATNPNGNLSYDATSTLTLPGHELPLPKLGVSAIKLKSLMNSTKESISLPVARECNTIVLCDSSVSTTDRPELLRLTGGSKTCQPSWIHSQHELNPQDSIVQGIFQLATLAKDKRFGLLLKETQPMKQKSVETSNGGVEETMKM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MALAISHEDTQIL --CCEEECCCCHHHH | 18.41 | 30377154 | |
| 10 | Phosphorylation | LAISHEDTQILLKDK EEECCCCHHHHHCCC | 17.96 | 24961812 | |
| 15 | Acetylation | EDTQILLKDKNILQE CCHHHHHCCCCHHHH | 64.31 | 24489116 | |
| 17 | Acetylation | TQILLKDKNILQESV HHHHHCCCCHHHHHH | 44.28 | 24489116 | |
| 27 | Acetylation | LQESVLNKYRTAGQI HHHHHHHHHHHHHHH | 31.76 | 24489116 | |
| 53 | Acetylation | INDSYHSKTTQRQLT HHCCCCCCCCCCCCC | 42.13 | 24489116 | |
| 332 | Ubiquitination | SLEHCTKKGLVTLET CCHHHHHCCCEEEEE | 39.05 | 24961812 | |
| 371 | Acetylation | FAQTHILKLKTSRQL HHHHHHEEEHHHHHH | 47.54 | 24489116 | |
| 413 | Acetylation | EEELQSLKKDLKSFR HHHHHHHHHHHHHHH | 49.87 | 24489116 | |
| 467 | Phosphorylation | YDATSTLTLPGHELP CCCCCEEECCCCCCC | 30.87 | 30377154 | |
| 481 | Phosphorylation | PLPKLGVSAIKLKSL CCCCCCCCHHHHHHH | 23.60 | 27214570 | |
| 484 | Acetylation | KLGVSAIKLKSLMNS CCCCCHHHHHHHHCC | 49.97 | 24489116 | |
| 487 | Phosphorylation | VSAIKLKSLMNSTKE CCHHHHHHHHCCCCC | 43.20 | 30377154 | |
| 491 | Phosphorylation | KLKSLMNSTKESISL HHHHHHCCCCCCCCC | 27.22 | 27017623 | |
| 493 | Acetylation | KSLMNSTKESISLPV HHHHCCCCCCCCCCH | 49.65 | 24489116 | |
| 495 | Phosphorylation | LMNSTKESISLPVAR HHCCCCCCCCCCHHC | 21.02 | 24909858 | |
| 570 | Acetylation | KRFGLLLKETQPMKQ CCCCEEEECCCCCCC | 59.70 | 24489116 | |
| 583 | Phosphorylation | KQKSVETSNGGVEET CCCCEECCCCCHHHH | 21.70 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARX1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARX1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARX1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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