| UniProt ID | LAS1_YEAST | |
|---|---|---|
| UniProt AC | P36146 | |
| Protein Name | Protein LAS1 | |
| Gene Name | LAS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 502 | |
| Subcellular Localization | Nucleus. Mitochondrion. | |
| Protein Description | Regulates cell surface growth, bud formation and morphogenesis. May act indirectly by regulating factor(s) involved in these processes.. | |
| Protein Sequence | MIPPRIVPWRDFAELEELKLWFYPKSKGTIEDKRQRAVQRVQSYRLKGSQYLPHVVDSTAQITCAVLLDEKEACLGVHQDSIPIRLSYVMALIRFVNGLLDPTQQSQFAIPLHTLAAKIGLPSWFVDLRHWGTHERDLPGLEMLRWAANEALSWLYDHYWNDEELEDDRDDDDDDDDTGYGYRRNDKLEKYMESLTKTLDKWKRLRNEFLEYKWVWENANDSLITSSNFSGDNLVNYDAEKRKSSHASSSETMIRENLRQWQELWKLSIYHNVVLEKFFNNYDPLLLKVLMLNLNNFDWKVIEWVARNYRTQQDDSNITTILKRKFNAWKELQKRLLDVIINNLNNKNFKNKWQNWEKLIDENASYLILYFCQSMLAKLETEKITGNSWRNKKRRKQIDSTVEIEAKLKENIDNLSLRFNEGEIKLYDFIPAEKDSVPLKKEVSPALKADTNDILGDLASLKQRMSSFGTVGKKNKQEENRATPVKNWSRVQNWKPKPFGVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 178 | Phosphorylation | DDDDDDDTGYGYRRN CCCCCCCCCCCHHHH | 39.02 | 27017623 | |
| 230 | Phosphorylation | LITSSNFSGDNLVNY EEECCCCCCCCCCCC | 49.87 | 28889911 | |
| 244 | Phosphorylation | YDAEKRKSSHASSSE CCHHHHHCCCCCCCH | 31.24 | 30377154 | |
| 248 | Phosphorylation | KRKSSHASSSETMIR HHHCCCCCCCHHHHH | 29.04 | 30377154 | |
| 249 | Phosphorylation | RKSSHASSSETMIRE HHCCCCCCCHHHHHH | 32.74 | 30377154 | |
| 252 | Phosphorylation | SHASSSETMIRENLR CCCCCCHHHHHHHHH | 21.61 | 30377154 | |
| 434 | Acetylation | YDFIPAEKDSVPLKK EEECCCCCCCCCCCC | 58.36 | 24489116 | |
| 444 | Phosphorylation | VPLKKEVSPALKADT CCCCCCCCHHHHCCC | 12.92 | 25521595 | |
| 451 | Phosphorylation | SPALKADTNDILGDL CHHHHCCCCCHHHHH | 39.38 | 21440633 | |
| 467 | Phosphorylation | SLKQRMSSFGTVGKK HHHHHHHHHCCCCCC | 20.53 | 21440633 | |
| 483 | Phosphorylation | KQEENRATPVKNWSR CCCCCCCCCCCCHHH | 25.94 | 27717283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LAS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LAS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LAS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND MASSSPECTROMETRY. | |
