GSHR_YEAST - dbPTM
GSHR_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GSHR_YEAST
UniProt AC P41921
Protein Name Glutathione reductase
Gene Name GLR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 483
Subcellular Localization Cytoplasm.
Protein Description Maintains high levels of reduced glutathione in the cytosol..
Protein Sequence MLSATKQTFRSLQIRTMSTNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSIDDVDELIWTIGRKSHLGMGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLSATKQT
-------CCCCHHHH		6.3522814378
2 (in isoform 2)Acetylation-4.8522814378
48AcetylationRAASYGAKTLLVEAK
HHHHCCCCEEEEEHH		35.0324489116
125UbiquitinationRLNGIYQKNLEKEKV
HHCCHHHHCCCHHCC		46.6723749301
125AcetylationRLNGIYQKNLEKEKV
HHCCHHHHCCCHHCC		46.6724489116
143AcetylationFGWARFNKDGNVEVQ
EEEEEECCCCCEEEE		65.3922865919
235AcetylationRGETVLRKFDECIQN
CCHHHHHHHHHHHHH		53.6724489116
2662-HydroxyisobutyrylationSKIVKVEKNVETDKL
HHEEEEECCCCCCEE		70.09-
342PhosphorylationVVGKVELTPVAIAAG
CCEEEECCHHHHHHC		11.3825752575
361AcetylationNRLFGPEKFRNDKLD
HCCCCCHHHCCCCCC		53.4024489116
366AcetylationPEKFRNDKLDYENVP
CHHHCCCCCCCCCCC		46.9724489116
395AcetylationSEKEAIEKYGKENIK
CHHHHHHHHCHHCCE		53.8724489116
396PhosphorylationEKEAIEKYGKENIKV
HHHHHHHHCHHCCEE		22.2021126336
402SuccinylationKYGKENIKVYNSKFT
HHCHHCCEEECHHHH		50.6923954790
402UbiquitinationKYGKENIKVYNSKFT
HHCHHCCEEECHHHH		50.6922817900
407UbiquitinationNIKVYNSKFTAMYYA
CCEEECHHHHHHHHH		43.0023749301
462UbiquitinationAIKMGATKADFDNCV
EEEECCCHHCCCCCE		45.4823749301
474PhosphorylationNCVAIHPTSAEELVT
CCEEECCCCHHHHHH		26.8030377154
475PhosphorylationCVAIHPTSAEELVTM
CEEECCCCHHHHHHC		37.8328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GSHR_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GSHR_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GSHR_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GSHR_YEASTGLR1physical
11967834
TRX2_YEASTTRX2genetic
8930901
ATG19_YEASTATG19physical
11283351
GSHR_YEASTGLR1physical
18467557
TOP1_YEASTTOP1genetic
18693244
TCM62_YEASTTCM62genetic
20093466
YPQ3_YEASTRTC2genetic
20093466
STE50_YEASTSTE50genetic
20093466
RV161_YEASTRVS161genetic
20093466
DHE2_YEASTGDH2genetic
20093466
MAF1_YEASTMAF1genetic
20093466
TPS2_YEASTTPS2genetic
20093466
RM01_YEASTMRPL1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
ATG1_YEASTATG1genetic
20093466
TRXB2_YEASTTRR2genetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
SAC1_YEASTSAC1genetic
20093466
NAP1_YEASTNAP1genetic
20093466
MSS1_YEASTMSS1genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
MED9_YEASTCSE2genetic
20093466
ATP23_YEASTATP23genetic
20093466
COQ7_YEASTCAT5genetic
20093466
MNE1_YEASTMNE1genetic
20093466
HAP5_YEASTHAP5genetic
20093466
QCR2_YEASTQCR2genetic
20093466
TRXB2_YEASTTRR2genetic
15701801
TRX3_YEASTTRX3genetic
15701801
TRX3_YEASTTRX3genetic
21623372
TRXB2_YEASTTRR2genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ATC3_YEASTDRS2genetic
21987634
ETR1_YEASTETR1genetic
21987634
CBS_YEASTCYS4genetic
21987634
ATP12_YEASTATP12genetic
21987634
TRX3_YEASTTRX3genetic
22770501
MCA1_YEASTMCA1genetic
22770501
PRX1_YEASTPRX1genetic
22770501
ATG1_YEASTATG1genetic
22282571
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GSHR_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475, AND MASSSPECTROMETRY.

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