dbPTM

TRX3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRX3_YEAST
UniProt AC	P25372
Protein Name	Thioredoxin-3, mitochondrial
Gene Name	TRX3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	127
Subcellular Localization	Mitochondrion.
Protein Description
Protein Sequence	MLFYKPVMRMAVRPLKSIRFQSSYTSITKLTNLTEFRNLIKQNDKLVIDFYATWCGPCKMMQPHLTKLIQAYPDVRFVKCDVDESPDIAKECEVTAMPTFVLGKDGQLIGKIIGANPTALEKGIKDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Succinylation	TEFRNLIKQNDKLVI HHHHHHHHHCCEEEE	46.33	23954790
67	Acetylation	MMQPHLTKLIQAYPD HHHHHHHHHHHHCCC	50.37	24489116
72	Phosphorylation	LTKLIQAYPDVRFVK HHHHHHHCCCCEEEE	5.42	22369663
79	Acetylation	YPDVRFVKCDVDESP CCCCEEEECCCCCCC	23.23	24489116
92	S-nitrosylation	SPDIAKECEVTAMPT CCCHHHHCEEEECCE	5.13	22178444
122	Ubiquitination	ANPTALEKGIKDL-- CCHHHHHHHCCCC--	67.78	23749301
122	Acetylation	ANPTALEKGIKDL-- CCHHHHHHHCCCC--	67.78	24489116
125	Acetylation	TALEKGIKDL----- HHHHHHCCCC-----	62.74	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRX3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRX3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRX3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSM1_YEAST	CSM1	physical	18719252
ADA2_YEAST	ADA2	physical	18719252
TRX3_YEAST	TRX3	physical	19166985
PFKA1_YEAST	PFK1	genetic	21623372
DCAM_YEAST	SPE2	genetic	21623372
SDT1_YEAST	SDT1	genetic	21623372
CYS3_YEAST	CYS3	genetic	21623372
AATC_YEAST	AAT2	genetic	21623372
GPP2_YEAST	GPP2	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
GSHR_YEAST	GLR1	genetic	21623372
ATP5E_YEAST	ATP15	genetic	21623372
SYSM_YEAST	DIA4	genetic	21623372
ACON2_YEAST	ACO2	genetic	21623372
APC11_YEAST	APC11	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
DAD1_YEAST	DAD1	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
PRP21_YEAST	PRP21	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
MED11_YEAST	MED11	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
ZN397_HUMAN	ZNF397	physical	27107014
T22D4_HUMAN	TSC22D4	physical	27107014
THAP1_HUMAN	THAP1	physical	27107014
FSBP_HUMAN	RAD54B	physical	27107014
RA54B_HUMAN	RAD54B	physical	27107014
SIAH1_HUMAN	SIAH1	physical	27107014
CEP70_HUMAN	CEP70	physical	27107014
DVL2_HUMAN	DVL2	physical	27107014
BEND7_HUMAN	BEND7	physical	27107014
TRIP6_HUMAN	TRIP6	physical	27107014
GOGA2_HUMAN	GOLGA2	physical	27107014
BANP_HUMAN	BANP	physical	27107014
FOS_HUMAN	FOS	physical	27107014
ABI2_HUMAN	ABI2	physical	27107014
TRI27_HUMAN	TRIM27	physical	27107014
FHL3_HUMAN	FHL3	physical	27107014
K1C15_HUMAN	KRT15	physical	27107014
UBX11_HUMAN	UBXN11	physical	27107014
IHO1_HUMAN	CCDC36	physical	27107014
WDR62_HUMAN	WDR62	physical	27107014
LZTS2_HUMAN	LZTS2	physical	27107014
ZBT8A_HUMAN	ZBTB8A	physical	27107014
IKZF1_HUMAN	IKZF1	physical	27107014
TFCP2_HUMAN	TFCP2	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRX3_YEAST

Related Literatures of Post-Translational Modification