| UniProt ID | SMF3_YEAST | |
|---|---|---|
| UniProt AC | Q12078 | |
| Protein Name | Iron transporter SMF3 | |
| Gene Name | SMF3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 473 | |
| Subcellular Localization |
Vacuole membrane Multi-pass membrane protein. Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | Has a role in controlling the cellular iron ion levels. Mobilizes vacuolar stores of iron in conditions of low iron levels.. | |
| Protein Sequence | MRSYMQILQKFAKFIGPGILVSVAYMDPGNYATSVSGGAQYKYTLLFSIFISNIFAVLLQCLCVKLGTITGYDLAENCRHNLPKKLNYTLYLFAEVAIIATDLAEVVGTAIALQILFKIPLTWGVLLTVLDVLVILMFYTPNGQSLKKVRVFEFGVGILVIGTCICFVLELFKVSIPDKAELFKGFLPSNIIFKEQQALYISLGILGATVMPHSLYLGSSIVKPRLHDYDLKKYGKVNARPSLSAIKYTLNYAYAELIISLFLIATFVNSAILIVAGATLSGQPEAEDADLLSIYKLLVHYISPAAGLIFALAMLCSGQSAGIICTLAGQIVSEGFLQWSLPPWATRLCTRLIAIVPCLFVTLTMGEKGISDILNFSQVVLSLILPIVSAPLIYFTANRKLMVVHDENGVVRAPADVNAIADETTPLNSKHSKIVDFTNSRLLTYTSVFVWALIGSLNCYLVISYLLGADIHF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 87 | N-linked_Glycosylation | HNLPKKLNYTLYLFA CCCCCCCCCHHHHHH | 36.30 | - | |
| 200 | Phosphorylation | FKEQQALYISLGILG EHHHHHHHHHHHHCC | 7.47 | 28889911 | |
| 202 | Phosphorylation | EQQALYISLGILGAT HHHHHHHHHHHCCCC | 13.64 | 28889911 | |
| 209 | Phosphorylation | SLGILGATVMPHSLY HHHHCCCCCCCCCCC | 18.62 | 28889911 | |
| 214 | Phosphorylation | GATVMPHSLYLGSSI CCCCCCCCCCCCCCC | 16.91 | 28889911 | |
| 216 | Phosphorylation | TVMPHSLYLGSSIVK CCCCCCCCCCCCCCC | 16.42 | 28889911 | |
| 424 | Phosphorylation | VNAIADETTPLNSKH HHHHCCCCCCCCCCC | 33.97 | 28889911 | |
| 425 | Phosphorylation | NAIADETTPLNSKHS HHHCCCCCCCCCCCC | 24.59 | 27214570 | |
| 429 | Phosphorylation | DETTPLNSKHSKIVD CCCCCCCCCCCCCCC | 39.15 | 27017623 | |
| 430 | Ubiquitination | ETTPLNSKHSKIVDF CCCCCCCCCCCCCCC | 51.31 | 23749301 | |
| 433 | Ubiquitination | PLNSKHSKIVDFTNS CCCCCCCCCCCCCCC | 46.60 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMF3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMF3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMF3_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LDS1_YEAST | LDS1 | physical | 16093310 | |
| PHO88_YEAST | PHO88 | physical | 16093310 | |
| VHC1_YEAST | VHC1 | physical | 16093310 | |
| VATL1_YEAST | VMA3 | physical | 16093310 | |
| VATO_YEAST | VMA16 | physical | 16093310 | |
| YET1_YEAST | YET1 | physical | 16093310 | |
| ERG3_YEAST | ERG3 | physical | 16093310 | |
| GAS3_YEAST | GAS3 | physical | 16093310 | |
| GPI2_YEAST | GPI2 | physical | 16093310 | |
| CR3L1_HUMAN | CREB3L1 | physical | 27107014 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-425, AND MASSSPECTROMETRY. | |
