| UniProt ID | PDAT_YEAST | |
|---|---|---|
| UniProt AC | P40345 | |
| Protein Name | Phospholipid:diacylglycerol acyltransferase | |
| Gene Name | LRO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 661 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | Triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.. | |
| Protein Sequence | MGTLFRRNVQNQKSDSDENNKGGSVHNKRESRNHIHHQQGLGHKRRRGISGSAKRNERGKDFDRKRDGNGRKRWRDSRRLIFILGAFLGVLLPFSFGAYHVHNSDSDLFDNFVNFDSLKVYLDDWKDVLPQGISSFIDDIQAGNYSTSSLDDLSENFAVGKQLLRDYNIEAKHPVVMVPGVISTGIESWGVIGDDECDSSAHFRKRLWGSFYMLRTMVMDKVCWLKHVMLDPETGLDPPNFTLRAAQGFESTDYFIAGYWIWNKVFQNLGVIGYEPNKMTSAAYDWRLAYLDLERRDRYFTKLKEQIELFHQLSGEKVCLIGHSMGSQIIFYFMKWVEAEGPLYGNGGRGWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAMYGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSEDALNNNTDTYGNFIRFERNTSDAFNKNLTMKDAINMTLSISPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHWSNPMEVPLPEAPHMKIYCIYGVNNPTERAYVYKEEDDSSALNLTIDYESKQPVFLTEGDGTVPLVAHSMCHKWAQGASPYNPAGINVTIVEMKHQPDRFDIRGGAKSAEHVDILGSAELNDYILKIASGNGDLVEPRQLSNLSQWVSQMPFPM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | VQNQKSDSDENNKGG CCCCCCCCCCCCCCC | 54.65 | 30377154 | |
| 50 | Phosphorylation | HKRRRGISGSAKRNE CCCCCCCCCCHHCCC | 29.53 | 28889911 | |
| 172 | Ubiquitination | RDYNIEAKHPVVMVP HHCCCCCCCCEEEEC | 35.33 | 17644757 | |
| 264 | Ubiquitination | AGYWIWNKVFQNLGV EHHHHHHHHHHHCCC | 29.45 | 17644757 | |
| 278 | Ubiquitination | VIGYEPNKMTSAAYD CCCCCCCCCCCHHHH | 55.03 | 23749301 | |
| 302 | Ubiquitination | RRDRYFTKLKEQIEL HHHHHHHHHHHHHHH | 47.89 | 17644757 | |
| 304 | Ubiquitination | DRYFTKLKEQIELFH HHHHHHHHHHHHHHH | 49.48 | 17644757 | |
| 317 | Ubiquitination | FHQLSGEKVCLIGHS HHHHCCCEEEEEEEC | 41.60 | 17644757 | |
| 371 | Ubiquitination | GTLLGAPKAVPALIS HHHCCCCCHHHHHHC | 62.57 | 17644757 | |
| 453 | N-linked_Glycosylation | NFIRFERNTSDAFNK HHHHEECCCHHHHHC | 36.42 | 30706417 | |
| 461 | N-linked_Glycosylation | TSDAFNKNLTMKDAI CHHHHHCCCCHHHHH | 41.68 | 30706417 | |
| 463 | Phosphorylation | DAFNKNLTMKDAINM HHHHCCCCHHHHHHH | 31.41 | 26447709 | |
| 469 | N-linked_Glycosylation | LTMKDAINMTLSISP CCHHHHHHHHEECCH | 21.07 | 30706417 | |
| 471 | Phosphorylation | MKDAINMTLSISPEW HHHHHHHHEECCHHH | 16.93 | 26447709 | |
| 473 | Phosphorylation | DAINMTLSISPEWLQ HHHHHHEECCHHHHH | 16.32 | 26447709 | |
| 475 | Phosphorylation | INMTLSISPEWLQRR HHHHEECCHHHHHHH | 17.25 | 26447709 | |
| 523 | Ubiquitination | LPEAPHMKIYCIYGV CCCCCCCEEEEEECC | 27.73 | 17644757 | |
| 594 | N-linked_Glycosylation | PYNPAGINVTIVEMK CCCCCCEEEEEEEEC | 24.78 | 30706417 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDAT_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDAT_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDAT_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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