SFB2_YEAST - dbPTM
SFB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SFB2_YEAST
UniProt AC P53953
Protein Name SED5-binding protein 2
Gene Name SFB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 876
Subcellular Localization Cytoplasm. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein Description Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex..
Protein Sequence MSHHKKRVYPQAQVPYIASMPIVAEQQQSQQQIDQTAYAMGNLQLNNRANSFTQLAQNQQFPGSGKVVNQLYPVDLFTELPPPIRDLSLPPLPITISQDNIVTPSEYSNVPYQYVRSTLKAVPKTNSLLKKTKLPFAIVIRPYLHLQDSDNQVPLNTDGVIVRCRRCRSYMNPFVVFINQGRKWQCNICRFKNDVPFGFDQNLQGAPINRYERNEIKNSVVDYLAPVEYSVREPPPSVYVFLLDVSQNAVKNGLLATSARTILENIEFLPNHDGRTRIAIICVDHSLHYFYVPLDDDYEVSDEDDEESDGEEEDEDEEEEDVDNSETIQMFDIGDLDEPFLPMPSDELVVPLKYCKNNLETLLKKIPEIFQDTHSSKFALGPALKAASNLIKSTGGKVEVISSTLPNTGIGKLKKRSEQGILNTPKESSQLLSCKDSFYKTFTIECNKLQITVDMFLASEDYMDVATLSHLGRFSGGQTHFYPGFNATSLNDVTKFTRELSRHLSMDISMEAVMRVRCSTGLRATSFFGHFFNRSSDLCAFSTMPRDQSYLFGISIEDSLMAEYCYLQVSTLLTLNTGERRIRVMTLALPTSESAREVFASADQLAITDFMTQNAVTKALNSSMYSARDFITKSLEDILNAYKKEISMSNINSVTSLNLCANLRMLPLLMNGLSKHIALRPGVVPSDYRASALNRLETEPLHYLIKSIYPTVYSLHDMPDEVGLPDFEGKTVLPEPINATISLFERYGLYLIDNSAELFLWVGGDAVPELLIDVFNTDTISQIPVGKSELPLLNDSPFNERLRRIIGRIRENNDTITFQSLYIIRGPSINEPANLNSEKDMASLRLWVLSTLVEDKVLNCASYREYLQSMKTSINR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationQLNNRANSFTQLAQN
HCCCCCCHHHHHHHH		28.7822369663
53PhosphorylationNNRANSFTQLAQNQQ
CCCCCHHHHHHHHCC		23.6122369663
97PhosphorylationPPLPITISQDNIVTP
CCCCCEECCCCCCCH		23.8828889911
192AcetylationQCNICRFKNDVPFGF
ECEEEEEECCCCCCC		32.6524489116
217UbiquitinationRYERNEIKNSVVDYL
HHHHHHHCCCHHHHC		36.6717644757
251UbiquitinationDVSQNAVKNGLLATS
ECCCHHHHCCCCHHH		42.7717644757
377AcetylationFQDTHSSKFALGPAL
HCCCCCCCCCHHHHH		37.3624489116
412AcetylationLPNTGIGKLKKRSEQ
CCCCCCCHHCHHHHC		56.0324489116
424PhosphorylationSEQGILNTPKESSQL
HHCCCCCCCHHHHHH		32.0928152593
495UbiquitinationTSLNDVTKFTRELSR
CCHHHHHHHHHHHHH		44.5817644757
501PhosphorylationTKFTRELSRHLSMDI
HHHHHHHHHHHCCCC		16.9528889911
509PhosphorylationRHLSMDISMEAVMRV
HHHCCCCCHHHHHHH		13.3028889911
709PhosphorylationHYLIKSIYPTVYSLH
HHHHHHHHCCCCCCC		10.4328132839
713PhosphorylationKSIYPTVYSLHDMPD
HHHHCCCCCCCCCCC		14.1628132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SFB2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SFB2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SFB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YRA1_YEASTYRA1physical
16554755
SEC23_YEASTSEC23physical
16554755
RL10_YEASTRPL10physical
16429126
RL7A_YEASTRPL7Aphysical
16429126
SEC23_YEASTSEC23physical
16429126
SPT6_YEASTSPT6physical
16429126
GOSR1_YEASTGOS1genetic
16269340
ERV14_YEASTERV14genetic
16269340
SEC22_YEASTSEC22genetic
16269340
GOT1_YEASTGOT1genetic
16269340
GET1_YEASTGET1genetic
16269340
TRS20_YEASTTRS20genetic
16269340
PDAT_YEASTLRO1genetic
16269340
LST8_YEASTLST8genetic
16269340
GET2_YEASTGET2genetic
16269340
COPE_YEASTSEC28genetic
16269340
OST5_YEASTOST5genetic
16269340
SEC23_YEASTSEC23physical
11283351
SEC23_YEASTSEC23physical
18719252
SSB1_YEASTSSB1physical
19536198
GET1_YEASTGET1genetic
19325107
GET2_YEASTGET2genetic
19325107
SEC22_YEASTSEC22genetic
19325107
GET3_YEASTGET3genetic
19325107
LHS1_YEASTLHS1genetic
19325107
SUM1_YEASTSUM1genetic
19325107
SWC5_YEASTSWC5genetic
19325107
SEC23_YEASTSEC23physical
20826334
SEC24_YEASTSEC24genetic
22157747
ORC2_YEASTORC2genetic
27708008
RRP45_YEASTRRP45genetic
27708008
NSE3_YEASTNSE3genetic
27708008
SRPR_YEASTSRP101genetic
27708008
GPI8_YEASTGPI8genetic
27708008
ACT_YEASTACT1genetic
27708008
MET30_YEASTMET30genetic
27708008
SMC3_YEASTSMC3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
GPI13_YEASTGPI13genetic
27708008
PGA3_YEASTPGA3genetic
27708008
ARP9_YEASTARP9genetic
27708008
MCM1_YEASTMCM1genetic
27708008
TIM50_YEASTTIM50genetic
27708008
MED10_YEASTNUT2genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SWT1_YEASTSWT1genetic
27708008
LSM2_YEASTLSM2genetic
27708008
STU1_YEASTSTU1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CALM_YEASTCMD1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
TRS20_YEASTTRS20genetic
27708008
CDC10_YEASTCDC10genetic
27708008
MPS1_YEASTMPS1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
USO1_YEASTUSO1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
TCPD_YEASTCCT4genetic
27708008
YRB1_YEASTYRB1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
PCF11_YEASTPCF11genetic
27708008
TSC11_YEASTTSC11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CCA1_YEASTCCA1genetic
27708008
GNA1_YEASTGNA1genetic
27708008
CAK1_YEASTCAK1genetic
27708008
YPT1_YEASTYPT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
ERG26_YEASTERG26genetic
27708008
CDC20_YEASTCDC20genetic
27708008
PRP43_YEASTPRP43genetic
27708008
COPB2_YEASTSEC27genetic
27708008
DBF2_YEASTDBF2genetic
27708008
OKP1_YEASTOKP1genetic
27708008
SYYC_YEASTTYS1genetic
27708008
YHI0_YEASTYHR020Wgenetic
27708008
MPPA_YEASTMAS2genetic
27708008
DNA2_YEASTDNA2genetic
27708008
BET1_YEASTBET1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
PRP21_YEASTPRP21genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RFC2_YEASTRFC2genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
CENPA_YEASTCSE4genetic
27708008
SN114_YEASTSNU114genetic
27708008
HYM1_YEASTHYM1genetic
27708008
YKT6_YEASTYKT6genetic
27708008
BET3_YEASTBET3genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
ERG27_YEASTERG27genetic
27708008
CLF1_YEASTCLF1genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
SEC39_YEASTSEC39genetic
27708008
RSE1_YEASTRSE1genetic
27708008
RNA14_YEASTRNA14genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
VTI1_YEASTVTI1genetic
27708008
TAF9_YEASTTAF9genetic
27708008
PRP24_YEASTPRP24genetic
27708008
FCP1_YEASTFCP1genetic
27708008
RPC1_YEASTRPO31genetic
27708008
ESA1_YEASTESA1genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PSB5_YEASTPRE2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
MRB1_YEASTPHO92genetic
27708008
GET2_YEASTGET2genetic
27708008
ERV14_YEASTERV14genetic
27708008
PEF1_YEASTPEF1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
CTK1_YEASTCTK1genetic
27708008
PRY2_YEASTPRY2genetic
27708008
YL413_YEASTINA1genetic
27708008
GTR1_YEASTGTR1genetic
27708008
ADH2_YEASTADH2genetic
27708008
SUCA_YEASTLSC1genetic
27708008
RUD3_YEASTRUD3genetic
27708008
TPO4_YEASTTPO4genetic
27708008
TGS1_YEASTTGS1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
PCL8_YEASTPCL8genetic
27708008
BRR1_YEASTBRR1genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
KLH12_HUMANKLHL12physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SFB2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; THR-53 AND SER-97,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, AND MASSSPECTROMETRY.

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