| UniProt ID | RNA14_YEAST | |
|---|---|---|
| UniProt AC | P25298 | |
| Protein Name | mRNA 3'-end-processing protein RNA14 | |
| Gene Name | RNA14 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 677 | |
| Subcellular Localization | Nucleus. Cytoplasm. Nucleus and/or cytoplasm. | |
| Protein Description | Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex.. | |
| Protein Sequence | MSSSTTPDLLYPSADKVAEPSDNIHGDELRLRERIKDNPTNILSYFQLIQYLETQESYAKVREVYEQFHNTFPFYSPAWTLQLKGELARDEFETVEKILAQCLSGKLENNDLSLWSTYLDYIRRKNNLITGGQEARAVIVKAFQLVMQKCAIFEPKSSSFWNEYLNFLEQWKPFNKWEEQQRIDMLREFYKKMLCVPFDNLEKMWNRYTQWEQEINSLTARKFIGELSAEYMKARSLYQEWLNVTNGLKRASPINLRTANKKNIPQPGTSDSNIQQLQIWLNWIKWERENKLMLSEDMLSQRISYVYKQGIQYMIFSAEMWYDYSMYISENSDRQNILYTALLANPDSPSLTFKLSECYELDNDSESVSNCFDKCTQTLLSQYKKIASDVNSGEDNNTEYEQELLYKQREKLTFVFCVYMNTMKRISGLSAARTVFGKCRKLKRILTHDVYVENAYLEFQNQNDYKTAFKVLELGLKYFQNDGVYINKYLDFLIFLNKDSQIKTLFETSVEKVQDLTQLKEIYKKMISYESKFGNLNNVYSLEKRFFERFPQENLIEVFTSRYQIQNSNLIKKLELTYMYNEEEDSYFSSGNGDGHHGSYNMSSSDRKRLMEETGNNGNFSNKKFKRDSELPTEVLDLLSVIPKRQYFNTNLLDAQKLVNFLNDQVEIPTVESTKSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSSTTPDL ------CCCCCCCCC | 32.75 | 22369663 | |
| 3 | Phosphorylation | -----MSSSTTPDLL -----CCCCCCCCCC | 30.33 | 22369663 | |
| 4 | Phosphorylation | ----MSSSTTPDLLY ----CCCCCCCCCCC | 29.06 | 22369663 | |
| 5 | Phosphorylation | ---MSSSTTPDLLYP ---CCCCCCCCCCCC | 44.27 | 22369663 | |
| 6 | Phosphorylation | --MSSSTTPDLLYPS --CCCCCCCCCCCCC | 19.43 | 22369663 | |
| 11 | Phosphorylation | STTPDLLYPSADKVA CCCCCCCCCCCCCCC | 11.48 | 22369663 | |
| 13 | Phosphorylation | TPDLLYPSADKVAEP CCCCCCCCCCCCCCC | 35.23 | 22369663 | |
| 252 | Phosphorylation | TNGLKRASPINLRTA CCCCHHCCCCCCCCC | 30.28 | 28889911 | |
| 305 | Phosphorylation | MLSQRISYVYKQGIQ HHHHHHHHHHHCCCC | 12.86 | 28889911 | |
| 307 | Phosphorylation | SQRISYVYKQGIQYM HHHHHHHHHCCCCEE | 6.86 | 28889911 | |
| 313 | Phosphorylation | VYKQGIQYMIFSAEM HHHCCCCEEEEEEEE | 7.11 | 27017623 | |
| 317 | Phosphorylation | GIQYMIFSAEMWYDY CCCEEEEEEEECCEE | 16.64 | 27017623 | |
| 322 | Phosphorylation | IFSAEMWYDYSMYIS EEEEEECCEEEEEEC | 12.05 | 27017623 | |
| 324 | Phosphorylation | SAEMWYDYSMYISEN EEEECCEEEEEECCC | 4.61 | 27017623 | |
| 329 | Phosphorylation | YDYSMYISENSDRQN CEEEEEECCCCCCCC | 17.15 | 27017623 | |
| 332 | Phosphorylation | SMYISENSDRQNILY EEEECCCCCCCCEEE | 30.07 | 27017623 | |
| 407 | Ubiquitination | YEQELLYKQREKLTF HHHHHHHHHHHHHHH | 42.73 | 23749301 | |
| 411 | Ubiquitination | LLYKQREKLTFVFCV HHHHHHHHHHHEEHH | 55.82 | 22817900 | |
| 478 | Phosphorylation | VLELGLKYFQNDGVY HHHHHHHHHHCCCEE | 18.55 | 28889911 | |
| 485 | Phosphorylation | YFQNDGVYINKYLDF HHHCCCEEHHHHHEE | 12.33 | 28889911 | |
| 523 | Phosphorylation | LTQLKEIYKKMISYE HHHHHHHHHHHHCHH | 12.97 | 27017623 | |
| 528 | Phosphorylation | EIYKKMISYESKFGN HHHHHHHCHHHHCCC | 21.25 | 27017623 | |
| 577 | Phosphorylation | LIKKLELTYMYNEEE HHHEEEEEEEECCCC | 9.25 | 30377154 | |
| 578 | Phosphorylation | IKKLELTYMYNEEED HHEEEEEEEECCCCC | 15.38 | 30377154 | |
| 603 | Phosphorylation | HHGSYNMSSSDRKRL CCCCCCCCHHHHHHH | 24.05 | 30377154 | |
| 623 | Acetylation | NNGNFSNKKFKRDSE CCCCCCCCCCCCCCC | 59.39 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNA14_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNA14_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNA14_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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