RAD7_YEAST - dbPTM
RAD7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD7_YEAST
UniProt AC P06779
Protein Name DNA repair protein RAD7
Gene Name RAD7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 565
Subcellular Localization
Protein Description Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents..
Protein Sequence MYRSRNRPKRGGENEVKGPNSALTQFLREEGISAENIKQKWYQRQSKKQEDATDEKKGKAEDDSFTAEISRVVEDEEIDEIGTGSGTETERAQVSYDARMKLVPADSDEEEYETSHISDTPVSLSSANDRESLTKKRQNTAKIIQNRRRKRKRAADLLDRRVNKVSSLQSLCITKISENISKWQKEADESSKLVFNKLRDVLGGVSTANLNNLAKALSKNRALNDHTLQLFLKTDLKRLTFSDCSKISFDGYKTLAIFSPHLTELSLQMCGQLNHESLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVIMKGRLEEFHISNTHRFTDKSLSNLLINCGSTLVSLGLSRLDSISNYALLPQYLVNDEFHSLCIEYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGCIDLTDSMIINGLTAFIPEKCPLEVLSLEESDQITTDSLSYFFSKVELNNLIECSFRRCLQLGDMAIIELLLNGARDSLRSLNLNSLKELTKEAFVALACPNLTYLDLGFVRCVDDSVIQMLGEQNPNLTVIDVFGDNLVTEKATMRPGLTLIGRQSDSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationFLREEGISAENIKQK
HHHHCCCCHHHHHHH		40.1530377154
64PhosphorylationKGKAEDDSFTAEISR
CCCCCCCCHHHHHHE		36.5022369663
66PhosphorylationKAEDDSFTAEISRVV
CCCCCCHHHHHHEEE		27.6022369663
70PhosphorylationDSFTAEISRVVEDEE
CCHHHHHHEEECHHH		15.5529688323
83PhosphorylationEEIDEIGTGSGTETE
HHCCCCCCCCCCCCE		33.5622369663
85PhosphorylationIDEIGTGSGTETERA
CCCCCCCCCCCCEEE		42.2422369663
87PhosphorylationEIGTGSGTETERAQV
CCCCCCCCCCEEEEE		41.2422369663
89PhosphorylationGTGSGTETERAQVSY
CCCCCCCCEEEEECC		30.5222369663
95PhosphorylationETERAQVSYDARMKL
CCEEEEECCCCCCCE		12.7623749301
96PhosphorylationTERAQVSYDARMKLV
CEEEEECCCCCCCEE		18.1128889911
107PhosphorylationMKLVPADSDEEEYET
CCEEECCCCHHHHHH		49.3721551504
112PhosphorylationADSDEEEYETSHISD
CCCCHHHHHHCCCCC		27.9921440633
114PhosphorylationSDEEEYETSHISDTP
CCHHHHHHCCCCCCC		25.3819779198
115PhosphorylationDEEEYETSHISDTPV
CHHHHHHCCCCCCCC		13.5921440633
118PhosphorylationEYETSHISDTPVSLS
HHHHCCCCCCCCCCC		29.9720377248
120PhosphorylationETSHISDTPVSLSSA
HHCCCCCCCCCCCCC		20.8521551504
123PhosphorylationHISDTPVSLSSANDR
CCCCCCCCCCCCCCH		24.6021551504
125PhosphorylationSDTPVSLSSANDRES
CCCCCCCCCCCCHHH		21.6526447709
126PhosphorylationDTPVSLSSANDRESL
CCCCCCCCCCCHHHH		36.0619779198
321PhosphorylationRLEEFHISNTHRFTD
CEEEEEECCCCCCCC		27.4027017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ELOC_YEASTELC1physical
11805837
UBI4P_YEASTUBI4physical
11805837
RAD16_YEASTRAD16physical
9001217
RAD4_YEASTRAD4physical
9001217
SIR3_YEASTSIR3physical
7958876
RAD4_YEASTRAD4physical
10446201
RAD23_YEASTRAD23physical
10446201
RAD16_YEASTRAD16physical
15226437
RAD16_YEASTRAD16physical
9268290
RAD16_YEASTRAD16physical
9792654
RAD16_YEASTRAD16physical
10601031
ABF1_YEASTABF1physical
10601031
RAD26_YEASTRAD26genetic
11254132
RPB1_YEASTRPO21genetic
11254132
RAD52_YEASTRAD52genetic
2697464
UBC2_YEASTRAD6genetic
2697464
RAD26_YEASTRAD26genetic
8552076
RAD26_YEASTRAD26genetic
9150262
H2A2_YEASTHTA2physical
16554755
ELOC_YEASTELC1physical
16554755
RAD16_YEASTRAD16physical
16675952
CUL3_YEASTCUL3physical
16675952
ELOC_YEASTELC1physical
16675952
RAD4_YEASTRAD4physical
16675952
NOT2_YEASTCDC36genetic
17314980
PAC11_YEASTPAC11genetic
17314980
UBC2_YEASTRAD6genetic
17314980
SIR3_YEASTSIR3physical
18719252
BIM1_YEASTBIM1genetic
19547744
BUR2_YEASTBUR2genetic
19197357
SPT3_YEASTSPT3genetic
19197357
MED15_YEASTGAL11genetic
19197357
MED2_YEASTMED2genetic
19197357
RFT1_YEASTRFT1genetic
19197357
SPT20_YEASTSPT20genetic
19197357
CDC73_YEASTCDC73genetic
19197357
NOT5_YEASTNOT5genetic
19197357
RPB9_YEASTRPB9genetic
19197357
UBC2_YEASTRAD6genetic
19197357
PAF1_YEASTPAF1genetic
19197357
LEO1_YEASTLEO1genetic
19197357
NOT4_YEASTMOT2genetic
19197357
NOT3_YEASTNOT3genetic
19197357
POP2_YEASTPOP2genetic
19197357
CCR4_YEASTCCR4genetic
19197357
BRE1_YEASTBRE1genetic
19197357
RAD9_YEASTRAD9genetic
19197357
DEF1_YEASTDEF1genetic
19197357
SPT5_YEASTSPT5genetic
20042611
SPT4_YEASTSPT4genetic
20042611
RAD23_YEASTRAD23genetic
15226437
RAD26_YEASTRAD26genetic
17537816
MEX67_YEASTMEX67genetic
17537816
SUB2_YEASTSUB2genetic
17537816
SAC3_YEASTSAC3genetic
17537816
THP1_YEASTTHP1genetic
17537816
HPR1_YEASTHPR1genetic
17537816
DEF1_YEASTDEF1genetic
17537816
SIZ1_YEASTSIZ1genetic
21968059
SIZ2_YEASTNFI1genetic
21968059
RAD26_YEASTRAD26genetic
24813444
SPT5_YEASTSPT5genetic
24813444
RPB9_YEASTRPB9genetic
27179024
RAD26_YEASTRAD26genetic
27179024
SEN1_YEASTSEN1genetic
27179024
YCY0_YEASTYCR090Cgenetic
27708008
RPA14_YEASTRPA14genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
INO4_YEASTINO4genetic
27708008
MGA1_YEASTMGA1genetic
27708008
AGE2_YEASTAGE2genetic
27708008
DID2_YEASTDID2genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
EFM7_YEASTNNT1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
KAR9_YEASTKAR9genetic
27708008
DEF1_YEASTDEF1genetic
28521214
UBP7_YEASTUBP7genetic
26740628
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-85 AND TYR-96,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.

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