MSB1_YEAST - dbPTM
MSB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSB1_YEAST
UniProt AC P21339
Protein Name Morphogenesis-related protein MSB1
Gene Name MSB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1137
Subcellular Localization
Protein Description May play a role in polarity establishment and bud formation. The MSB1 gene may be functionally redundant..
Protein Sequence MNDMAKPLPTPPTAEIRKSRSNSPKKAQKTNLSPNKNQNNEKNVPRSNGRTKNEHNSMDDEEFEFFHQFSREKVKGVIHVITAELKEKGPDVEFLMIPFRPEQTNDKLLTLLNQLFPLGNGQPVNEKKQLRIVSKADVWTLFQCLKYIWCRLPNSEIIGWKSYLEFKFREEDKKFPRKSFLEIMPQCLASPNHASIVYDFFDLIISISSNSRVNKMSARKISKMCAIWAFSKQIPNSDIQDYDFESAAMKSFAPNNSIQDGLDQWIPASDAMFHLLLAFLRSFVPQDLESAKLPRTLKSLLFNNQYPPRKSTAYTSETILTIPLVTLKTDVFSRKPWQLLERCNDLLDFSDHDAFEAREDYALLKSLFRKKNTVEGISRKMSQESRRLMKAMSTKHSTFQPGWAPRECIENISHLKECIEVKRLDIDDYFIWTWLSSLSFEQTSEKKKIFGRSIILEFEFDGFKKWVVFQECDITLDYNKKGQLKKKTSAQSPTTEKELPPDDFELEDPPLSKSPTLSQTYKKFQAEVPQQSTVRRDSAPDNQGIYHTVISKNALTKNKHNVNLHSFEHKISKWNPLNNLRKKSGSNSSSSSFEEKSKDAPIREEYHTNKNHKSKKEERVLSQFSTLNPDEYQLPVIETGSSNFKIEIPELMYEHDDDDSDKLKNSQKRATDSAIEELNGMVEEMMINEPDDVKISITEAETFESLTKFDQYKPSNITDDDLQSSHSSAVHSLKLSTNTNDSCADSSKYTADRKLAEPRKISEESKVNDDSSSYYSPNINNLPASRMPSQPTYSNSDSKKAFTNESRLNVLQGAVSPSQQVTPKPYKNAPGDCVSPVQQKYYQNDRRNEMSPASAPVPPSAYSPARSPQFSTNSAGFKQNTINVPVGYNDPAHVLANQPHMTYRDQHNYPSHQQKQRPFQNNIVPPELKSRNQRADASPIPQHMVPVKQGVPNLPSNVPLYQQMERMNPNHQHPVNTYKVTQPPYHNNTTNAYGNSRAGNAHMLDGKWSNNPPQMVPKGVRPNQYPQQHVNRYSPQAQPVVPAEYYNGPPPMRAPPMMSHMVPAQEPIRYTAGANRRSFPQGMQQNAYSVPAQPMGAVNSEFYLPEAPQGNKLHGNINKRQERKKLYDNIRSGNFGI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationDMAKPLPTPPTAEIR
CCCCCCCCCCCHHHH		49.9721551504
13PhosphorylationKPLPTPPTAEIRKSR
CCCCCCCCHHHHHHC		37.8224961812
19PhosphorylationPTAEIRKSRSNSPKK
CCHHHHHHCCCCCCH		30.9621440633
21PhosphorylationAEIRKSRSNSPKKAQ
HHHHHHCCCCCCHHH		49.0721440633
23PhosphorylationIRKSRSNSPKKAQKT
HHHHCCCCCCHHHHC		39.0721440633
30PhosphorylationSPKKAQKTNLSPNKN
CCCHHHHCCCCCCCC		29.3427017623
33PhosphorylationKAQKTNLSPNKNQNN
HHHHCCCCCCCCCCC		28.6125521595
57PhosphorylationRTKNEHNSMDDEEFE
CCCCCCCCCCHHHHH		26.0424961812
242PhosphorylationPNSDIQDYDFESAAM
CCCCCCCCCHHHHHH		13.2228132839
488PhosphorylationKGQLKKKTSAQSPTT
CCCCCCCCCCCCCCC		37.8721440633
489PhosphorylationGQLKKKTSAQSPTTE
CCCCCCCCCCCCCCC		32.9427214570
492PhosphorylationKKKTSAQSPTTEKEL
CCCCCCCCCCCCCCC		24.7525521595
494PhosphorylationKTSAQSPTTEKELPP
CCCCCCCCCCCCCCC		53.4819823750
495PhosphorylationTSAQSPTTEKELPPD
CCCCCCCCCCCCCCC		48.7425521595
512PhosphorylationELEDPPLSKSPTLSQ
CCCCCCCCCCCCHHH		36.5421440633
514PhosphorylationEDPPLSKSPTLSQTY
CCCCCCCCCCHHHHH		21.5325521595
516PhosphorylationPPLSKSPTLSQTYKK
CCCCCCCCHHHHHHH		46.2422369663
518PhosphorylationLSKSPTLSQTYKKFQ
CCCCCCHHHHHHHHH		23.9722369663
520PhosphorylationKSPTLSQTYKKFQAE
CCCCHHHHHHHHHCC		33.6522369663
521PhosphorylationSPTLSQTYKKFQAEV
CCCHHHHHHHHHCCC		12.4421440633
532PhosphorylationQAEVPQQSTVRRDSA
HCCCCCCCCCCCCCC		24.5019823750
533PhosphorylationAEVPQQSTVRRDSAP
CCCCCCCCCCCCCCC		17.4424961812
538PhosphorylationQSTVRRDSAPDNQGI
CCCCCCCCCCCCCCC		39.6317330950
546PhosphorylationAPDNQGIYHTVISKN
CCCCCCCEEEEEECC		9.7722890988
548PhosphorylationDNQGIYHTVISKNAL
CCCCCEEEEEECCCC		11.5428889911
573AcetylationSFEHKISKWNPLNNL
HHHHHHHHCCHHHCC		55.2324489116
584PhosphorylationLNNLRKKSGSNSSSS
HHCCHHHCCCCCCCC		50.9527717283
586PhosphorylationNLRKKSGSNSSSSSF
CCHHHCCCCCCCCCH		40.4028889911
588PhosphorylationRKKSGSNSSSSSFEE
HHHCCCCCCCCCHHH		33.0428889911
589PhosphorylationKKSGSNSSSSSFEEK
HHCCCCCCCCCHHHH		38.1928889911
590PhosphorylationKSGSNSSSSSFEEKS
HCCCCCCCCCHHHHH		29.8030377154
591PhosphorylationSGSNSSSSSFEEKSK
CCCCCCCCCHHHHHC		40.7828889911
592PhosphorylationGSNSSSSSFEEKSKD
CCCCCCCCHHHHHCC		38.3325752575
622PhosphorylationKKEERVLSQFSTLNP
HHHHHHHHHHHCCCC		26.7321551504
626PhosphorylationRVLSQFSTLNPDEYQ
HHHHHHHCCCCCCCC		31.6621551504
639PhosphorylationYQLPVIETGSSNFKI
CCCCEEECCCCCEEE		31.1030377154
660PhosphorylationYEHDDDDSDKLKNSQ
EECCCCCCHHHHHHH		43.5720377248
673PhosphorylationSQKRATDSAIEELNG
HHHHHHHHHHHHHHH		27.1321440633
702PhosphorylationISITEAETFESLTKF
EEEEEHHHHHHHHCC		39.4922369663
705PhosphorylationTEAETFESLTKFDQY
EEHHHHHHHHCCCCC		36.8322369663
707PhosphorylationAETFESLTKFDQYKP
HHHHHHHHCCCCCCC		38.6622369663
712PhosphorylationSLTKFDQYKPSNITD
HHHCCCCCCCCCCCH		27.0619823750
715PhosphorylationKFDQYKPSNITDDDL
CCCCCCCCCCCHHHH		36.3920377248
718PhosphorylationQYKPSNITDDDLQSS
CCCCCCCCHHHHHCC		37.3124961812
724PhosphorylationITDDDLQSSHSSAVH
CCHHHHHCCCHHHHH		37.0021440633
725PhosphorylationTDDDLQSSHSSAVHS
CHHHHHCCCHHHHHE		17.9021440633
727PhosphorylationDDLQSSHSSAVHSLK
HHHHCCCHHHHHEEE		23.1821440633
728PhosphorylationDLQSSHSSAVHSLKL
HHHCCCHHHHHEEEE		28.9621440633
732PhosphorylationSHSSAVHSLKLSTNT
CCHHHHHEEEECCCC		22.1721440633
742PhosphorylationLSTNTNDSCADSSKY
ECCCCCCCCCCCHHH		17.1821440633
747PhosphorylationNDSCADSSKYTADRK
CCCCCCCHHHHHCHH		30.1721440633
750PhosphorylationCADSSKYTADRKLAE
CCCCHHHHHCHHHCC		26.3121440633
762PhosphorylationLAEPRKISEESKVND
HCCCCCCCCHHCCCC		38.0421440633
765PhosphorylationPRKISEESKVNDDSS
CCCCCCHHCCCCCCC		37.5421440633
771PhosphorylationESKVNDDSSSYYSPN
HHCCCCCCCCCCCCC		24.8519779198
772PhosphorylationSKVNDDSSSYYSPNI
HCCCCCCCCCCCCCC		29.3827017623
773PhosphorylationKVNDDSSSYYSPNIN
CCCCCCCCCCCCCCC		31.8521551504
774PhosphorylationVNDDSSSYYSPNINN
CCCCCCCCCCCCCCC		15.2027017623
775PhosphorylationNDDSSSYYSPNINNL
CCCCCCCCCCCCCCC		21.4319779198
776PhosphorylationDDSSSYYSPNINNLP
CCCCCCCCCCCCCCC		11.8428152593
789PhosphorylationLPASRMPSQPTYSNS
CCHHHCCCCCCCCCC		39.1723749301
803PhosphorylationSDSKKAFTNESRLNV
CHHHCCCCCHHHHHH		42.8321440633
806PhosphorylationKKAFTNESRLNVLQG
HCCCCCHHHHHHHHC		44.1021440633
816PhosphorylationNVLQGAVSPSQQVTP
HHHHCCCCHHHCCCC		20.4917330950
818PhosphorylationLQGAVSPSQQVTPKP
HHCCCCHHHCCCCCC		26.2428889911
822PhosphorylationVSPSQQVTPKPYKNA
CCHHHCCCCCCCCCC		22.6628889911
835PhosphorylationNAPGDCVSPVQQKYY
CCCCCCCCHHHHHHH		26.1925533186
851PhosphorylationNDRRNEMSPASAPVP
CCCCCCCCCCCCCCC		15.9028889911
854PhosphorylationRNEMSPASAPVPPSA
CCCCCCCCCCCCHHH		36.1728889911
860PhosphorylationASAPVPPSAYSPARS
CCCCCCHHHCCCCCC		33.4927017623
862PhosphorylationAPVPPSAYSPARSPQ
CCCCHHHCCCCCCCC		21.3721440633
863PhosphorylationPVPPSAYSPARSPQF
CCCHHHCCCCCCCCC		16.2923749301
867PhosphorylationSAYSPARSPQFSTNS
HHCCCCCCCCCCCCC		25.7621440633
874PhosphorylationSPQFSTNSAGFKQNT
CCCCCCCCCCCCCCC		29.8329734811
909PhosphorylationTYRDQHNYPSHQQKQ
CHHHCCCCCCHHCCC		12.1830377154
930PhosphorylationIVPPELKSRNQRADA
CCCHHHHHHCCCCCC		49.4321440633
938PhosphorylationRNQRADASPIPQHMV
HCCCCCCCCCCCCCC		24.7421440633
1033PhosphorylationPQQHVNRYSPQAQPV
CHHHCCCCCCCCCCC		21.3528889911
1034PhosphorylationQQHVNRYSPQAQPVV
HHHCCCCCCCCCCCC		13.8029734811
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BNI1_YEASTBNI1physical
11489916
YP216_YEASTYPL216Wphysical
16554755
CDC42_YEASTCDC42physical
23785492
MSB1_YEASTMSB1physical
23785492
CSN12_YEASTYJR084Wgenetic
27708008
ENV10_YEASTENV10genetic
27708008
KPC1_YEASTPKC1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
LTE1_YEASTLTE1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
MET8_YEASTMET8genetic
27708008
CBT1_YEASTCBT1genetic
27708008
COX12_YEASTCOX12genetic
27708008
NST1_YEASTNST1genetic
27708008
RMI1_YEASTRMI1genetic
27708008
COX10_YEASTCOX10genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSB1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33; SER-492; SER-538;SER-591; SER-705; SER-851 AND SER-854, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538 AND SER-816, ANDMASS SPECTROMETRY.

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