PFS2_YEAST - dbPTM
PFS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PFS2_YEAST
UniProt AC P42841
Protein Name Polyadenylation factor subunit 2
Gene Name PFS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 465
Subcellular Localization Nucleus .
Protein Description Integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May bridge the CPF and CFIA complexes..
Protein Sequence MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationKYVTQRRSVDVSSPY
HHHCCCCCCCCCCCC		25.5128889911
167PhosphorylationKIWQPNFSMVKEIDA
EEECCCCCEEEEECH		29.3419779198
177PhosphorylationKEIDAAHTESIRDMA
EEECHHCCHHHHHHC		27.0529136822
179PhosphorylationIDAAHTESIRDMAFS
ECHHCCHHHHHHCCC		24.8729136822
236PhosphorylationPEMGLIASASKDNLV
CCCCEEEEECCCCCE		26.5321440633
238PhosphorylationMGLIASASKDNLVKL
CCEEEEECCCCCEEE		37.7421440633
464PhosphorylationSSTLPGLSI------
CCCCCCCCC------		31.9721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PFS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PFS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PFS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CFT1_YEASTCFT1physical
11805826
CFT2_YEASTCFT2physical
11805826
PAP_YEASTPAP1physical
11805826
PTA1_YEASTPTA1physical
11805826
PTI1_YEASTPTI1physical
11805826
YSH1_YEASTYSH1physical
11805826
TCPB_YEASTCCT2physical
11805837
TCPA_YEASTTCP1physical
11805837
TCPE_YEASTCCT5physical
11805837
TCPZ_YEASTCCT6physical
11805837
CFT1_YEASTCFT1physical
11805837
HGH1_YEASTHGH1physical
11805837
FIP1_YEASTFIP1physical
12453421
PP12_YEASTGLC7physical
12453421
MPE1_YEASTMPE1physical
12453421
PAP_YEASTPAP1physical
12453421
PTA1_YEASTPTA1physical
12453421
PTI1_YEASTPTI1physical
12453421
REF2_YEASTREF2physical
12453421
SSU72_YEASTSSU72physical
12453421
SWD1_YEASTSWD1physical
12453421
CFT2_YEASTCFT2physical
12453421
CFT1_YEASTCFT1physical
12453421
YSH1_YEASTYSH1physical
12453421
YSH1_YEASTYSH1physical
11713271
FIP1_YEASTFIP1physical
11713271
MPE1_YEASTMPE1physical
11713271
PAP_YEASTPAP1physical
11713271
PTA1_YEASTPTA1physical
11713271
CFT2_YEASTCFT2physical
11713271
CFT1_YEASTCFT1physical
11713271
CFT1_YEASTCFT1physical
10619842
PAP_YEASTPAP1physical
10619842
PTA1_YEASTPTA1physical
10619842
YSH1_YEASTYSH1physical
10619842
FIP1_YEASTFIP1physical
10619842
RNA14_YEASTRNA14physical
10619842
GIP4_YEASTGIP4physical
16554755
PTA1_YEASTPTA1physical
16554755
YBB0_YEASTYBL010Cphysical
16554755
TYR1_YEASTTYR1physical
16554755
REF2_YEASTREF2physical
16554755
YRA1_YEASTYRA1physical
16554755
PP12_YEASTGLC7physical
16554755
PUF4_YEASTPUF4physical
16554755
PTI1_YEASTPTI1physical
16554755
YHI9_YEASTYHI9physical
16554755
FIP1_YEASTFIP1physical
16554755
SWD2_YEASTSWD2physical
16554755
MPE1_YEASTMPE1physical
16554755
PAP_YEASTPAP1physical
16554755
STM1_YEASTSTM1physical
16554755
SSU72_YEASTSSU72physical
16554755
YTH1_YEASTYTH1physical
16554755
CFT1_YEASTCFT1physical
16429126
CFT2_YEASTCFT2physical
16429126
PAP_YEASTPAP1physical
16429126
PTA1_YEASTPTA1physical
16429126
PTI1_YEASTPTI1physical
16429126
SWD2_YEASTSWD2physical
16429126
YSH1_YEASTYSH1physical
16429126
PP12_YEASTGLC7physical
16429126
MPE1_YEASTMPE1physical
16429126
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PFS2_YEAST

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Related Literatures of Post-Translational Modification

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