dbPTM

YSH1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YSH1_YEAST
UniProt AC	Q06224
Protein Name	Endoribonuclease YSH1
Gene Name	YSH1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	779
Subcellular Localization	Nucleus .
Protein Description	Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Has endonuclease activity..
Protein Sequence	MERTNTTTFKFFSLGGSNEVGRSCHILQYKGKTVMLDAGIHPAYQGLASLPFYDEFDLSKVDILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLRDFVRVTSIGSSSSSMGTKDEGLFSDEDLVDSFDKIETVDYHSTVDVNGIKFTAFHAGHVLGAAMFQIEIAGLRVLFTGDYSREVDRHLNSAEVPPLSSNVLIVESTFGTATHEPRLNRERKLTQLIHSTVMRGGRVLLPVFALGRAQEIMLILDEYWSQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFIFKNISYLRNLEDFQDFGPSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKFIMLEPDTIPSINNPEITIPRRCQVEEISFAAHVDFQENLEFIEKISAPNIILVHGEANPMGRLKSALLSNFASLKGTDNEVHVFNPRNCVEVDLEFQGVKVAKAVGNIVNEIYKEENVEIKEEIAAKIEPIKEENEDNLDSQAEKGLVDEEEHKDIVVSGILVSDDKNFELDFLSLSDLREHHPDLSTTILRERQSVRVNCKKELIYWHILQMFGEAEVLQDDDRVTNQEPKVKEESKDNLTNTGKLILQIMGDIKLTIVNTLAVVEWTQDLMNDTVADSIIAILMNVDSAPASVKLSSHSCDDHDHNNVQSNAQGKIDEVERVKQISRLFKEQFGDCFTLFLNKDEYASNKEETITGVVTIGKSTAKIDFNNMKILECNSNPLKGRVESLLNIGGNLVTPLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
365	Phosphorylation	DKNLVLITGYSIEGT CCCEEEEEEEEEECC	26.38	19795423
367	Phosphorylation	NLVLITGYSIEGTMA CEEEEEEEEEECCEE	9.60	19823750
368	Phosphorylation	LVLITGYSIEGTMAK EEEEEEEEEECCEEE	18.60	19823750
372	Phosphorylation	TGYSIEGTMAKFIML EEEEEECCEEEEEEE	10.93	19823750
517	Phosphorylation	ENEDNLDSQAEKGLV CCCCCCHHHHHHCCC	34.16	22369663
521	Acetylation	NLDSQAEKGLVDEEE CCHHHHHHCCCCHHH	61.64	24489116
535	Phosphorylation	EHKDIVVSGILVSDD HHHCEEEEEEEECCC	14.82	27017623
540	Phosphorylation	VVSGILVSDDKNFEL EEEEEEECCCCCEEE	36.32	27017623
551	Phosphorylation	NFELDFLSLSDLREH CEEEEEECHHHHHHH	26.31	28132839
666	Phosphorylation	AILMNVDSAPASVKL HHHHCCCCCCCCCCC	31.69	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
517	S	Phosphorylation	Kinase	ATM	P38110	Uniprot
517	S	Phosphorylation	Kinase	ATR	P38111	Uniprot
517	S	Phosphorylation	Kinase	ATM/ATR	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YSH1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YSH1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CFT1_YEAST	CFT1	physical	11805826
CFT2_YEAST	CFT2	physical	11805826
FIP1_YEAST	FIP1	physical	11805826
PAP_YEAST	PAP1	physical	11805826
PFS2_YEAST	PFS2	physical	11805826
PTA1_YEAST	PTA1	physical	11805826
REF2_YEAST	REF2	physical	11805826
MPE1_YEAST	MPE1	physical	11805826
PP12_YEAST	GLC7	physical	11805826
YTH1_YEAST	YTH1	physical	11805826
CLP1_YEAST	CLP1	physical	12853609
TFC4_YEAST	TFC4	physical	12853609
CFT1_YEAST	CFT1	physical	16554755
FIP1_YEAST	FIP1	physical	16554755
PAP_YEAST	PAP1	physical	16554755
CORO_YEAST	CRN1	physical	16554755
YNU8_YEAST	YNL208W	physical	16554755
PFS2_YEAST	PFS2	physical	16554755
YTH1_YEAST	YTH1	physical	16554755
CFT1_YEAST	CFT1	physical	16429126
CFT2_YEAST	CFT2	physical	16429126
FIP1_YEAST	FIP1	physical	16429126
PP12_YEAST	GLC7	physical	16429126
MPE1_YEAST	MPE1	physical	16429126
PAP_YEAST	PAP1	physical	16429126
PFS2_YEAST	PFS2	physical	16429126
PTA1_YEAST	PTA1	physical	16429126
REF2_YEAST	REF2	physical	16429126
SWD2_YEAST	SWD2	physical	16429126
YTH1_YEAST	YTH1	physical	16429126
SYC1_YEAST	SYC1	genetic	16431986
CLP1_YEAST	CLP1	physical	22216186

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YSH1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND SER-666, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, AND MASSSPECTROMETRY.	17563356 [Abstract]