SPT6_YEAST - dbPTM
SPT6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPT6_YEAST
UniProt AC P23615
Protein Name Transcription elongation factor SPT6
Gene Name SPT6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1451
Subcellular Localization Nucleus . Colocalizes with RNA polymerase II on chromatin. Recruited to the active transcribed loci.
Protein Description Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability..
Protein Sequence MEETGDSKLVPRDEEEIVNDNDETKAPSEEEEGEDVFDSSEEDEDIDEDEDEARKVQEGFIVNDDDENEDPGTSISKKRRKHKRREREEDDRLSEDDLDLLMENAGVERTKASSSSGKFKRLKRVGDEGNAAESESDNVAASRQDSTSKLEDFFSEDEEEEESGLRNGRNNEYGRDEEDHENRNRTADKGGILDELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDYDWALEIENEELENGNDNNEAEEEEIDEETGAIKSTKKKISLQDIYDLEDLKKNLMTEGDMKIRKTDIPERYQELRAGITDYGNMSSEDQELERNWIAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYISSREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNSLQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISAEDVGENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIREKVRSDFSKYYLADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAESLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEWNNFRKLAFNQAMDKIFQDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPNVRDPKIPKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLYISWNEKRQKYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDEIFQSLTGESEKTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPANEIYEIGKTYPAKVIYIDYANITAEVSLLDHDVKQQYVPISYSKDPSIWDLKQELEDAEEERKLMMAEARAKRTHRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8AcetylationMEETGDSKLVPRDEE
CCCCCCCCCCCCCHH		59.2425381059
24PhosphorylationIVNDNDETKAPSEEE
HCCCCCCCCCCCHHH		35.0619823750
28PhosphorylationNDETKAPSEEEEGED
CCCCCCCCHHHCCCC		63.6019823750
39PhosphorylationEGEDVFDSSEEDEDI
CCCCCCCCCCCCCCC		28.3419795423
40PhosphorylationGEDVFDSSEEDEDID
CCCCCCCCCCCCCCC		47.0219795423
73PhosphorylationDENEDPGTSISKKRR
CCCCCCCCCHHHHHH		28.4230377154
74PhosphorylationENEDPGTSISKKRRK
CCCCCCCCHHHHHHH		30.6823749301
76PhosphorylationEDPGTSISKKRRKHK
CCCCCCHHHHHHHHH		31.7128889911
94PhosphorylationREEDDRLSEDDLDLL
HHHHHCCCHHHHHHH		39.6122369663
110PhosphorylationENAGVERTKASSSSG
HHCCCCCCCCCCCCC		19.9127017623
111AcetylationNAGVERTKASSSSGK
HCCCCCCCCCCCCCC		53.1225381059
116PhosphorylationRTKASSSSGKFKRLK
CCCCCCCCCCCEECE		48.2027017623
118AcetylationKASSSSGKFKRLKRV
CCCCCCCCCEECEEC		50.0524489116
120AcetylationSSSSGKFKRLKRVGD
CCCCCCCEECEECCC		61.3825381059
134PhosphorylationDEGNAAESESDNVAA
CCCCCCCCCCCCCCH		37.3622369663
136PhosphorylationGNAAESESDNVAASR
CCCCCCCCCCCCHHC		43.7122369663
142PhosphorylationESDNVAASRQDSTSK
CCCCCCHHCCCCCHH		22.2722890988
146PhosphorylationVAASRQDSTSKLEDF
CCHHCCCCCHHHHHH		26.6622369663
147PhosphorylationAASRQDSTSKLEDFF
CHHCCCCCHHHHHHC		37.8620377248
148PhosphorylationASRQDSTSKLEDFFS
HHCCCCCHHHHHHCC		38.9122369663
155PhosphorylationSKLEDFFSEDEEEEE
HHHHHHCCCCHHHHH		44.1022369663
163PhosphorylationEDEEEEESGLRNGRN
CCHHHHHHCCCCCCC		46.5422369663
186PhosphorylationDHENRNRTADKGGIL
HHCCCCCCCCCCCHH		42.6426447709
206PhosphorylationFIEDDEFSDEDDETR
HHCCCCCCCCCHHHH		37.7322369663
212PhosphorylationFSDEDDETRQRRIQE
CCCCCHHHHHHHHHH		38.8122369663
227PhosphorylationKKLLREQSIKQPTQI
HHHHHHCCCCCCCCC		27.3128889911
229AcetylationLLREQSIKQPTQITG
HHHHCCCCCCCCCCC		56.3122865919
232PhosphorylationEQSIKQPTQITGLSS
HCCCCCCCCCCCCCH		30.0621126336
235PhosphorylationIKQPTQITGLSSDKI
CCCCCCCCCCCHHHH		23.4222369663
238PhosphorylationPTQITGLSSDKIDEM
CCCCCCCCHHHHHHH		37.5222369663
239PhosphorylationTQITGLSSDKIDEMY
CCCCCCCHHHHHHHH		48.2222369663
295PhosphorylationKSTKKKISLQDIYDL
CCCCCCCCHHHHCCH		28.9422369663
300PhosphorylationKISLQDIYDLEDLKK
CCCHHHHCCHHHHHH		23.8222369663
340PhosphorylationITDYGNMSSEDQELE
CCCCCCCCHHHHHHH		34.2827017623
341PhosphorylationTDYGNMSSEDQELER
CCCCCCCHHHHHHHH		34.1327017623
354UbiquitinationERNWIAEKISVDKNF
HHHCHHHHHCCCCCC		31.1224961812
379AcetylationEAIGNAIKFITKENL
HHHHHHHHHHCCCCC		28.4424489116
491AcetylationMFINHTGKTGKKHLK
HHHCCCCCCCCHHHC		56.0824489116
576AcetylationLAIDTVQKYYSLELS
EEHHHHHHHHHHHCC		41.6524489116
746AcetylationIPNVRDPKIPKILSL
CCCCCCCCCCCEEEE		75.7624489116
749AcetylationVRDPKIPKILSLTCG
CCCCCCCCEEEEECC		60.8024489116
781AcetylationGDFIRDYKIVDNPFD
CCCCEECCCCCCCCC		40.3124489116
824PhosphorylationNPKTQKFYKRLQEVL
CHHHHHHHHHHHHHH		11.3928889911
876PhosphorylationNKPPLVKYCIALARY
CCCHHHHHHHHHHHH		5.0028889911
883PhosphorylationYCIALARYMHSPLLE
HHHHHHHHHCCHHHH		8.1228889911
886PhosphorylationALARYMHSPLLEYAN
HHHHHHCCHHHHHCC		10.7428889911
891PhosphorylationMHSPLLEYANLTSEE
HCCHHHHHCCCCHHH		10.7628889911
895PhosphorylationLLEYANLTSEEVRSL
HHHHCCCCHHHHHHC		33.6228889911
949AcetylationNYYASALKYISGFGK
CHHHHHHHHHHCCCH		40.0124489116
1007AcetylationSWNEKRQKYEDLEHD
ECCHHHHHHHCCCCC		55.4224489116
1134AcetylationESEKTFFKGSIIPVR
CCCCCEECCCEEEEE		47.7822865919
1239AcetylationEDAEEERKLMMAEAR
HHHHHHHHHHHHHHH		43.9725381059
1355AcetylationNEMTSSEKFKSGTKK
HHCCCCCHHCCCCHH		61.1024489116
1355UbiquitinationNEMTSSEKFKSGTKK
HHCCCCCHHCCCCHH		61.1023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPT6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPT6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPT6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSK21_YEASTCKA1physical
11805826
CSK22_YEASTCKA2physical
11805826
CSK2B_YEASTCKB1physical
11805826
IWS1_YEASTSPN1physical
11805826
IWS1_YEASTSPN1physical
12242279
SPT4_YEASTSPT4physical
12556496
SPT5_YEASTSPT5physical
12556496
MCES_YEASTABD1physical
12556496
SPT16_YEASTSPT16physical
12556496
IWS1_YEASTSPN1physical
12556496
POB3_YEASTPOB3physical
12556496
SPT4_YEASTSPT4genetic
1330823
CCR4_YEASTCCR4genetic
7896086
CCR4_YEASTCCR4genetic
6392016
CCR4_YEASTCCR4genetic
1459446
POP2_YEASTPOP2genetic
7791755
RPB1_YEASTRPO21genetic
15531585
RPB2_YEASTRPB2genetic
15531585
ELF1_YEASTELF1genetic
16260625
CSK21_YEASTCKA1physical
16429126
CSK22_YEASTCKA2physical
16429126
CSK2B_YEASTCKB1physical
16429126
MOT3_YEASTMOT3genetic
9528759
RAS2_YEASTRAS2genetic
14668364
PP2C4_YEASTPTC4genetic
19269370
PP2C1_YEASTPTC1genetic
19269370
PP2A1_YEASTPPH21genetic
19269370
HAC1_YEASTHAC1genetic
19269370
VID30_YEASTVID30genetic
19269370
KHSE_YEASTTHR1genetic
19269370
CTF8_YEASTCTF8genetic
19269370
RPA34_YEASTRPA34genetic
19269370
MNN11_YEASTMNN11genetic
19269370
CTK1_YEASTCTK1genetic
19269370
SAC1_YEASTSAC1genetic
19269370
PTPA2_YEASTRRD2genetic
19269370
H3_YEASTHHT1genetic
8844144
H4_YEASTHHF1genetic
8844144
PAF1_YEASTPAF1genetic
15531585
CTR9_YEASTCTR9genetic
15531585
CDC73_YEASTCDC73genetic
15531585
IWS1_YEASTSPN1physical
20826334
IWS1_YEASTSPN1genetic
21094070
NHP6A_YEASTNHP6Agenetic
21094070
NHP6B_YEASTNHP6Bgenetic
21094070
RPB1_YEASTRPO21physical
21676864
H3_YEASTHHT1physical
22914091
SPT2_YEASTSPT2physical
23979598
CTK1_YEASTCTK1physical
24163256
RPB1_YEASTRPO21physical
24163256
TAF5_YEASTTAF5genetic
27708008
GPN2_YEASTGPN2genetic
27708008
CDC15_YEASTCDC15genetic
27708008
MCM2_YEASTMCM2genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
ALG14_YEASTALG14genetic
27708008
MCES_YEASTABD1genetic
27708008
NSE4_YEASTNSE4genetic
27708008
PSF1_YEASTPSF1genetic
27708008
SEC1_YEASTSEC1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
PCF11_YEASTPCF11genetic
27708008
SLD5_YEASTSLD5genetic
27708008
SEC20_YEASTSEC20genetic
27708008
SMT3_YEASTSMT3genetic
27708008
COG3_YEASTCOG3genetic
27708008
CAK1_YEASTCAK1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
NDC80_YEASTNDC80genetic
27708008
MCM10_YEASTMCM10genetic
27708008
NU192_YEASTNUP192genetic
27708008
PSF2_YEASTPSF2genetic
27708008
DPB11_YEASTDPB11genetic
27708008
ESS1_YEASTESS1genetic
27708008
NUP85_YEASTNUP85genetic
27708008
KTHY_YEASTCDC8genetic
27708008
PRI2_YEASTPRI2genetic
27708008
RSC4_YEASTRSC4genetic
27708008
NSE1_YEASTNSE1genetic
27708008
MED14_YEASTRGR1genetic
27708008
CDC45_YEASTCDC45genetic
27708008
NMT_YEASTNMT1genetic
27708008
MCM5_YEASTMCM5genetic
27708008
RU1C_YEASTYHC1genetic
27708008
SC61A_YEASTSEC61genetic
27708008
AFG2_YEASTAFG2genetic
27708008
POB3_YEASTPOB3genetic
27708008
TAP42_YEASTTAP42genetic
27708008
UTP15_YEASTUTP15genetic
27708008
SPC24_YEASTSPC24genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
CLP1_YEASTCLP1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
SEC16_YEASTSEC16genetic
27708008
CET1_YEASTCET1genetic
27708008
IF6_YEASTTIF6genetic
27708008
ARP7_YEASTARP7genetic
27708008
IWS1_YEASTSPN1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ORC4_YEASTORC4genetic
27708008
DPM1_YEASTDPM1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
HPC2_YEASTHPC2genetic
27708008
ATG15_YEASTATG15genetic
27708008
NHP10_YEASTNHP10genetic
27708008
VPS41_YEASTVPS41genetic
27708008
AP3S_YEASTAPS3genetic
27708008
PEP8_YEASTPEP8genetic
27708008
VPS35_YEASTVPS35genetic
27708008
SET2_YEASTSET2genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
SA190_YEASTSAP190genetic
27708008
SET3_YEASTSET3genetic
27708008
BRE2_YEASTBRE2genetic
27708008
VPS38_YEASTVPS38genetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
VPS9_YEASTVPS9genetic
27708008
MUB1_YEASTMUB1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
RTG1_YEASTRTG1genetic
27708008
VAM3_YEASTVAM3genetic
27708008
ARB1_YEASTARB1genetic
28637236
DBP6_YEASTDBP6genetic
28637236
BUR2_YEASTBUR2genetic
28637236
SPT4_YEASTSPT4genetic
28637236
IWS1_YEASTSPN1genetic
28637236
MPG1_YEASTPSA1genetic
28637236
RSA1_YEASTRSA1genetic
28637236
MRT4_YEASTMRT4genetic
28637236
ZUO1_YEASTZUO1genetic
28637236
ARX1_YEASTARX1genetic
28637236
RPB1_YEASTRPO21physical
28826505
SWR1_YEASTSWR1genetic
25959393
H2AZ_YEASTHTZ1genetic
25959393
RPB1_YEASTRPO21physical
25182531
RPB3_YEASTRPB3physical
25182531
H3_YEASTHHT1physical
25182531
H4_YEASTHHF1physical
25182531
RPB3_YEASTRPB3physical
29695490
SPT16_YEASTSPT16genetic
29695490
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPT6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-76; SER-94;SER-134; SER-136; SER-148; SER-155 AND SER-206, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-134; SER-136;SER-146 AND SER-155, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-134; SER-136;SER-155 AND SER-206, AND MASS SPECTROMETRY.

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