| UniProt ID | YRB1_YEAST | |
|---|---|---|
| UniProt AC | P41920 | |
| Protein Name | Ran-specific GTPase-activating protein 1 | |
| Gene Name | YRB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 201 | |
| Subcellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. | |
| Protein Description | Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.. | |
| Protein Sequence | MSSEDKKPVVDKKEEAAPKPPSSAVFSMFGGKKAEKPETKKDEEDTKEETKKEGDDAPESPDIHFEPVVHLEKVDVKTMEEDEEVLYKVRAKLFRFDADAKEWKERGTGDCKFLKNKKTNKVRILMRRDKTLKICANHIIAPEYTLKPNVGSDRSWVYACTADIAEGEAEAFTFAIRFGSKENADKFKEEFEKAQEINKKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSEDKKPV ------CCCCCCCCC | 42.29 | 22369663 | |
| 3 | Phosphorylation | -----MSSEDKKPVV -----CCCCCCCCCC | 48.82 | 28132839 | |
| 6 | Acetylation | --MSSEDKKPVVDKK --CCCCCCCCCCCHH | 55.73 | 25381059 | |
| 7 | Acetylation | -MSSEDKKPVVDKKE -CCCCCCCCCCCHHH | 56.20 | 25381059 | |
| 22 | Phosphorylation | EAAPKPPSSAVFSMF HCCCCCCCCHHHHHH | 39.18 | 24909858 | |
| 23 | Phosphorylation | AAPKPPSSAVFSMFG CCCCCCCCHHHHHHC | 33.94 | 23749301 | |
| 27 | Phosphorylation | PPSSAVFSMFGGKKA CCCCHHHHHHCCCCC | 13.45 | 21440633 | |
| 32 | Acetylation | VFSMFGGKKAEKPET HHHHHCCCCCCCCCC | 49.54 | 24489116 | |
| 36 | Acetylation | FGGKKAEKPETKKDE HCCCCCCCCCCCCCH | 53.68 | 25381059 | |
| 50 | Phosphorylation | EEDTKEETKKEGDDA HHHHHHHHHHCCCCC | 48.81 | 22369663 | |
| 60 | Phosphorylation | EGDDAPESPDIHFEP CCCCCCCCCCCCEEC | 27.15 | 22369663 | |
| 73 | Acetylation | EPVVHLEKVDVKTME ECCEEEEEEECCCCC | 50.52 | 24489116 | |
| 77 | Ubiquitination | HLEKVDVKTMEEDEE EEEEEECCCCCCCHH | 37.38 | 23749301 | |
| 77 | Acetylation | HLEKVDVKTMEEDEE EEEEEECCCCCCCHH | 37.38 | 24489116 | |
| 77 | Succinylation | HLEKVDVKTMEEDEE EEEEEECCCCCCCHH | 37.38 | 23954790 | |
| 78 | Phosphorylation | LEKVDVKTMEEDEEV EEEEECCCCCCCHHH | 29.66 | 21440633 | |
| 88 | Acetylation | EDEEVLYKVRAKLFR CCHHHHHHHHHHHHC | 22.53 | 24489116 | |
| 88 | Ubiquitination | EDEEVLYKVRAKLFR CCHHHHHHHHHHHHC | 22.53 | 23749301 | |
| 92 | Ubiquitination | VLYKVRAKLFRFDAD HHHHHHHHHHCCCCC | 37.28 | 22817900 | |
| 101 | Acetylation | FRFDADAKEWKERGT HCCCCCHHHHHHHCC | 65.73 | 24489116 | |
| 101 | Ubiquitination | FRFDADAKEWKERGT HCCCCCHHHHHHHCC | 65.73 | 23749301 | |
| 104 | Acetylation | DADAKEWKERGTGDC CCCHHHHHHHCCCCC | 38.33 | 24489116 | |
| 112 | Acetylation | ERGTGDCKFLKNKKT HHCCCCCCCCCCCCC | 59.48 | 24489116 | |
| 112 | Ubiquitination | ERGTGDCKFLKNKKT HHCCCCCCCCCCCCC | 59.48 | 23749301 | |
| 115 | Ubiquitination | TGDCKFLKNKKTNKV CCCCCCCCCCCCCCE | 70.61 | 22817900 | |
| 117 | Ubiquitination | DCKFLKNKKTNKVRI CCCCCCCCCCCCEEE | 60.43 | 22817900 | |
| 133 | Acetylation | MRRDKTLKICANHII ECCCCHHHHHHHCCC | 40.76 | 24489116 | |
| 147 | Acetylation | IAPEYTLKPNVGSDR CCCCCCCCCCCCCCC | 27.09 | 24489116 | |
| 147 | Ubiquitination | IAPEYTLKPNVGSDR CCCCCCCCCCCCCCC | 27.09 | 23749301 | |
| 186 | Acetylation | GSKENADKFKEEFEK CCHHHHHHHHHHHHH | 56.79 | 24489116 | |
| 188 | Acetylation | KENADKFKEEFEKAQ HHHHHHHHHHHHHHH | 63.17 | 24489116 | |
| 193 | Acetylation | KFKEEFEKAQEINKK HHHHHHHHHHHHHHH | 61.77 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of YRB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YRB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YRB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-60, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY. | |
