RL17A_YEAST - dbPTM
RL17A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL17A_YEAST
UniProt AC P05740
Protein Name 60S ribosomal protein L17-A {ECO:0000303|PubMed:9559554}
Gene Name RPL17A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 184
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKVVRLTSRQRGRIAAQKRIAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MARYGATSTNPAKS
-CCCCCCCCCCCCCC		31.5522369663
8PhosphorylationMARYGATSTNPAKSA
CCCCCCCCCCCCCCC		26.1722369663
9PhosphorylationARYGATSTNPAKSAS
CCCCCCCCCCCCCCC		40.6522369663
132-HydroxyisobutyrylationATSTNPAKSASARGS
CCCCCCCCCCCCCCC		48.05-
13UbiquitinationATSTNPAKSASARGS
CCCCCCCCCCCCCCC		48.0523749301
14PhosphorylationTSTNPAKSASARGSY
CCCCCCCCCCCCCCE		29.5717287358
16PhosphorylationTNPAKSASARGSYLR
CCCCCCCCCCCCEEE		26.1128889911
20PhosphorylationKSASARGSYLRVSFK
CCCCCCCCEEEEEEE		18.5522369663
21PhosphorylationSASARGSYLRVSFKN
CCCCCCCEEEEEEEC		11.0122369663
25PhosphorylationRGSYLRVSFKNTRET
CCCEEEEEEECHHHH		24.8622369663
27AcetylationSYLRVSFKNTRETAQ
CEEEEEEECHHHHHH		50.3224489116
27SuccinylationSYLRVSFKNTRETAQ
CEEEEEEECHHHHHH		50.3223954790
272-HydroxyisobutyrylationSYLRVSFKNTRETAQ
CEEEEEEECHHHHHH		50.32-
32PhosphorylationSFKNTRETAQAINGW
EEECHHHHHHHHCHH		22.3021440633
43AcetylationINGWELTKAQKYLEQ
HCHHHHHHHHHHHHH		62.5424489116
43UbiquitinationINGWELTKAQKYLEQ
HCHHHHHHHHHHHHH		62.5423749301
46UbiquitinationWELTKAQKYLEQVLD
HHHHHHHHHHHHHHH		57.5723749301
46AcetylationWELTKAQKYLEQVLD
HHHHHHHHHHHHHHH		57.5724489116
65PhosphorylationIPFRRFNSSIGRTAQ
CCHHHCCCCCCCCCC		22.1825533186
66PhosphorylationPFRRFNSSIGRTAQG
CHHHCCCCCCCCCCC		30.1125533186
70PhosphorylationFNSSIGRTAQGKEFG
CCCCCCCCCCCCCCC		20.3717287358
74UbiquitinationIGRTAQGKEFGVTKA
CCCCCCCCCCCCCCC		37.4823749301
74SuccinylationIGRTAQGKEFGVTKA
CCCCCCCCCCCCCCC		37.4823954790
74AcetylationIGRTAQGKEFGVTKA
CCCCCCCCCCCCCCC		37.4824489116
742-HydroxyisobutyrylationIGRTAQGKEFGVTKA
CCCCCCCCCCCCCCC		37.48-
80AcetylationGKEFGVTKARWPAKS
CCCCCCCCCCCCHHH		33.2822865919
80UbiquitinationGKEFGVTKARWPAKS
CCCCCCCCCCCCHHH		33.2823749301
80SuccinylationGKEFGVTKARWPAKS
CCCCCCCCCCCCHHH		33.2823954790
802-HydroxyisobutyrylationGKEFGVTKARWPAKS
CCCCCCCCCCCCHHH		33.28-
862-HydroxyisobutyrylationTKARWPAKSVKFVQG
CCCCCCHHHHHHHHH		52.26-
86UbiquitinationTKARWPAKSVKFVQG
CCCCCCHHHHHHHHH		52.2622817900
87PhosphorylationKARWPAKSVKFVQGL
CCCCCHHHHHHHHHH		32.4221440633
89UbiquitinationRWPAKSVKFVQGLLQ
CCCHHHHHHHHHHHH		47.0823749301
89AcetylationRWPAKSVKFVQGLLQ
CCCHHHHHHHHHHHH		47.0824489116
105UbiquitinationAAANAEAKGLDATKL
HHHHHHHCCCCCCEE		52.0623749301
105SuccinylationAAANAEAKGLDATKL
HHHHHHHCCCCCCEE		52.0623954790
105AcetylationAAANAEAKGLDATKL
HHHHHHHCCCCCCEE		52.0624489116
111UbiquitinationAKGLDATKLYVSHIQ
HCCCCCCEEEEEEEE		39.2723749301
1112-HydroxyisobutyrylationAKGLDATKLYVSHIQ
HCCCCCCEEEEEEEE		39.27-
111AcetylationAKGLDATKLYVSHIQ
HCCCCCCEEEEEEEE		39.2724489116
113PhosphorylationGLDATKLYVSHIQVN
CCCCCEEEEEEEECC		11.0621440633
115PhosphorylationDATKLYVSHIQVNQA
CCCEEEEEEEECCCC		11.0028152593
124AcetylationIQVNQAPKQRRRTYR
EECCCCHHHHHHHHH		60.4924489116
124UbiquitinationIQVNQAPKQRRRTYR
EECCCCHHHHHHHHH		60.4923749301
138UbiquitinationRAHGRINKYESSPSH
HHHCCCCCCCCCCCE		48.2822817900
138AcetylationRAHGRINKYESSPSH
HHHCCCCCCCCCCCE		48.2824489116
139PhosphorylationAHGRINKYESSPSHI
HHCCCCCCCCCCCEE		19.2929734811
141PhosphorylationGRINKYESSPSHIEL
CCCCCCCCCCCEEEE		44.4522369663
142PhosphorylationRINKYESSPSHIELV
CCCCCCCCCCEEEEE		20.6222369663
144PhosphorylationNKYESSPSHIELVVT
CCCCCCCCEEEEEEE		38.7622369663
153AcetylationIELVVTEKEEAVAKA
EEEEEECHHHHHHHH		52.0324489116
153UbiquitinationIELVVTEKEEAVAKA
EEEEEECHHHHHHHH		52.0324961812
159UbiquitinationEKEEAVAKAAEKKVV
CHHHHHHHHHHHHHH		41.3417644757
159AcetylationEKEEAVAKAAEKKVV
CHHHHHHHHHHHHHH		41.3422865919
1592-HydroxyisobutyrylationEKEEAVAKAAEKKVV
CHHHHHHHHHHHHHH		41.34-
170PhosphorylationKKVVRLTSRQRGRIA
HHHHHHHHHHHCCHH		30.8917287358
1802-HydroxyisobutyrylationRGRIAAQKRIAA---
HCCHHHHHHHCC---		40.83-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL17A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL17A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL17A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCN4_YEASTGCN4genetic
18423200
RL17B_YEASTRPL17Bgenetic
22377630
DAP2_YEASTDAP2physical
24072706
ACT_YEASTACT1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
KCY_YEASTURA6genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SNT1_YEASTSNT1genetic
27708008
THRC_YEASTTHR4genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PPME1_YEASTPPE1genetic
27708008
PTH_YEASTPTH1genetic
27708008
ALB1_YEASTALB1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
YJ24_YEASTKCH1genetic
27708008
TSR2_YEASTTSR2genetic
27708008
SOK2_YEASTSOK2genetic
27708008
2A5D_YEASTRTS1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
APC11_YEASTAPC11genetic
27708008
FBRL_YEASTNOP1genetic
27708008
TECR_YEASTTSC13genetic
27708008
UBC9_YEASTUBC9genetic
27708008
SNU23_YEASTSNU23genetic
27708008
NHP2_YEASTNHP2genetic
27708008
MAK21_YEASTMAK21genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
ALG2_YEASTALG2genetic
27708008
RCC1_YEASTSRM1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
PAN1_YEASTPAN1genetic
27708008
CDC16_YEASTCDC16genetic
27708008
SDO1_YEASTSDO1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
DPOA_YEASTPOL1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
CLP1_YEASTCLP1genetic
27708008
SYA_YEASTALA1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
KIN3_YEASTKIN3genetic
27708008
SLA1_YEASTSLA1genetic
27708008
ALG3_YEASTALG3genetic
27708008
LDH1_YEASTLDH1genetic
27708008
HPC2_YEASTHPC2genetic
27708008
REI1_YEASTREI1genetic
27708008
ABP1_YEASTABP1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
MRX9_YEASTYDL027Cgenetic
27708008
RRP8_YEASTRRP8genetic
27708008
LIC4_YEASTATC1genetic
27708008
SHE9_YEASTSHE9genetic
27708008
VPS60_YEASTVPS60genetic
27708008
IES1_YEASTIES1genetic
27708008
RL29_YEASTRPL29genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
PALF_YEASTRIM8genetic
27708008
DBP3_YEASTDBP3genetic
27708008
PBP1_YEASTPBP1genetic
27708008
PIH1_YEASTPIH1genetic
27708008
MSC7_YEASTMSC7genetic
27708008
WSS1_YEASTWSS1genetic
27708008
ADY1_YEASTPFS1genetic
27708008
VID28_YEASTVID28genetic
27708008
CSN11_YEASTPCI8genetic
27708008
SER33_YEASTSER33genetic
27708008
6P21_YEASTPFK26genetic
27708008
ALN_YEASTDAL1genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
RS14B_YEASTRPS14Bgenetic
27708008
SRP40_YEASTSRP40genetic
27708008
SKI2_YEASTSKI2genetic
27708008
YPT7_YEASTYPT7genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
GTR1_YEASTGTR1genetic
27708008
GBLP_YEASTASC1genetic
27708008
RGM1_YEASTRGM1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
DOM34_YEASTDOM34genetic
27708008
YO098_YEASTYOL098Cgenetic
27708008
MSN1_YEASTMSN1genetic
27708008
AHC1_YEASTAHC1genetic
27708008
HIR2_YEASTHIR2genetic
27708008
CY1_YEASTCYT1genetic
27708008
SKI7_YEASTSKI7genetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP084_YEASTYPR084Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL17A_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-65 AND SER-66,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.

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