DBP2_YEAST - dbPTM
DBP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DBP2_YEAST
UniProt AC P24783
Protein Name ATP-dependent RNA helicase DBP2
Gene Name DBP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 546
Subcellular Localization Cytoplasm. Nucleus.
Protein Description ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing..
Protein Sequence MTYGGRDQQYNKTNYKSRGGDFRGGRNSDRNSYNDRPQGGNYRGGFGGRSNYNQPQELIKPNWDEELPKLPTFEKNFYVEHESVRDRSDSEIAQFRKENEMTISGHDIPKPITTFDEAGFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRDMVGIAATGSGKTLSYCLPGIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQTECSKFGHSSRIRNTCVYGGVPKSQQIRDLSRGSEIVIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVKQLAADYLNDPIQVQVGSLELSASHNITQIVEVVSDFEKRDRLNKYLETASQDNEYKTLIFASTKRMCDDITKYLREDGWPALAIHGDKDQRERDWVLQEFRNGRSPIMVATDVAARGIDVKGINYVINYDMPGNIEDYVHRIGRTGRAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPELLKYDRRSYGGGHPRYGGGRGGRGGYGRRGGYGGGRGGYGGNRQRDGGWGNRGRSNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12AcetylationGRDQQYNKTNYKSRG
CCCCCCCCCCCCCCC		32.9622865919
50PhosphorylationRGGFGGRSNYNQPQE
CCCCCCCCCCCCCHH		47.1130377154
60UbiquitinationNQPQELIKPNWDEEL
CCCHHHCCCCCCCCC		44.9423749301
60AcetylationNQPQELIKPNWDEEL
CCCHHHCCCCCCCCC		44.9424489116
75AcetylationPKLPTFEKNFYVEHE
CCCCCCCCCEEECCC		48.4424489116
83PhosphorylationNFYVEHESVRDRSDS
CEEECCCCCCCCCHH		25.1024961812
88PhosphorylationHESVRDRSDSEIAQF
CCCCCCCCHHHHHHH		50.1822369663
90PhosphorylationSVRDRSDSEIAQFRK
CCCCCCHHHHHHHHH		31.9522369663
135AcetylationVKAEGFDKPTGIQCQ
HHCCCCCCCCCCEEC		42.0724489116
208AcetylationQIQTECSKFGHSSRI
HHHHHHHHCCCCHHH		68.0024489116
218PhosphorylationHSSRIRNTCVYGGVP
CCHHHCCCEEECCCC		8.1029136822
221PhosphorylationRIRNTCVYGGVPKSQ
HHCCCEEECCCCHHH		15.4329136822
226UbiquitinationCVYGGVPKSQQIRDL
EEECCCCHHHHHHHH		59.5023749301
227PhosphorylationVYGGVPKSQQIRDLS
EECCCCHHHHHHHHH		22.6523749301
255AcetylationIDMLEIGKTNLKRVT
EEHHHHCCCCCEEEE		39.6424489116
283AcetylationGFEPQIRKIVDQIRP
CCHHHHHHHHHHHCC		49.0322865919
303AcetylationMWSATWPKEVKQLAA
EEECCCCHHHHHHHH		67.7024489116
350AcetylationEKRDRLNKYLETASQ
HHHHHHHHHHHHHCC		56.6624489116
356PhosphorylationNKYLETASQDNEYKT
HHHHHHHCCCCCHHH		45.5527017623
362AcetylationASQDNEYKTLIFAST
HCCCCCHHHHEEECH		30.5824489116
363PhosphorylationSQDNEYKTLIFASTK
CCCCCHHHHEEECHH		24.9619795423
368PhosphorylationYKTLIFASTKRMCDD
HHHHEEECHHHHHHH		24.5819823750
369PhosphorylationKTLIFASTKRMCDDI
HHHEEECHHHHHHHH		21.1719823750
370AcetylationTLIFASTKRMCDDIT
HHEEECHHHHHHHHH		35.3225381059
378AcetylationRMCDDITKYLREDGW
HHHHHHHHHHHHHCC		42.4924489116
451PhosphorylationYVHRIGRTGRAGATG
HHHHHCCCCCCCCCC		26.3027017623
459PhosphorylationGRAGATGTAISFFTE
CCCCCCCCCHHHHHH		19.2327017623
462PhosphorylationGATGTAISFFTEQNK
CCCCCCHHHHHHCCC		16.3127017623
469UbiquitinationSFFTEQNKGLGAKLI
HHHHHCCCCHHHHHH		56.0322817900
474UbiquitinationQNKGLGAKLISIMRE
CCCCHHHHHHHHHHH		44.5523749301
474AcetylationQNKGLGAKLISIMRE
CCCCHHHHHHHHHHH		44.5524489116
492AcetylationNIPPELLKYDRRSYG
CCCHHHHHCCCCCCC		58.7024489116
497PhosphorylationLLKYDRRSYGGGHPR
HHHCCCCCCCCCCCC		29.0828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DBP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DBP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DBP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSB2_YEASTSSB2physical
16554755
RSSA2_YEASTRPS0Bphysical
16429126
RSSA1_YEASTRPS0Aphysical
16429126
GYL1_YEASTGYL1physical
16429126
PRS8_YEASTRPT6physical
16429126
GIS2_YEASTGIS2physical
18467557
NOC2_YEASTNOC2physical
18467557
UBP10_YEASTUBP10physical
18467557
DBP2_YEASTDBP2physical
18467557
BRX1_YEASTBRX1physical
18467557
AIR1_YEASTAIR1genetic
19061648
SIF2_YEASTSIF2genetic
19061648
RPB4_YEASTRPB4genetic
19061648
PUF2_YEASTPUF2genetic
19061648
SSB1_YEASTSSB1physical
19536198
RRP6_YEASTRRP6genetic
22679025
YRA1_YEASTYRA1genetic
23721653
MEX67_YEASTMEX67genetic
23721653
YRA1_YEASTYRA1physical
23721653
ERF3_YEASTSUP35genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
NBP2_YEASTNBP2genetic
27708008
PP2C3_YEASTPTC3genetic
27708008
SCC1_YEASTMCD1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
FCF1_YEASTFCF1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CCA1_YEASTCCA1genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
ERG26_YEASTERG26genetic
27708008
ATC7_YEASTNEO1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
ERB1_YEASTERB1genetic
27708008
HAS1_YEASTHAS1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
BIG1_YEASTBIG1genetic
27708008
ORC6_YEASTORC6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
TYSY_YEASTCDC21genetic
27708008
APC5_YEASTAPC5genetic
27708008
DIB1_YEASTDIB1genetic
27708008
CHK1_YEASTCHK1genetic
27708008
STE50_YEASTSTE50genetic
27708008
ATC5_YEASTDNF1genetic
27708008
CGR1_YEASTCGR1genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
ENO1_YEASTENO1genetic
27708008
MAL12_YEASTMAL12genetic
27708008
MED20_YEASTSRB2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
SAC1_YEASTSAC1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
SUR7_YEASTSUR7genetic
27708008
SPC2_YEASTSPC2genetic
27708008
ERV41_YEASTERV41genetic
27708008
YM24_YEASTYMR147Wgenetic
27708008
TRI1_YEASTTRI1genetic
27708008
LCF4_YEASTFAA4genetic
27708008
HPF1_YEASTHPF1genetic
27708008
YVC1_YEASTYVC1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SGF11_YEASTSGF11genetic
27708008
THRC_YEASTTHR4genetic
27708008
ATG1_YEASTATG1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
HMI1_YEASTHMI1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
ATG15_YEASTATG15genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
SAC3_YEASTSAC3genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
AIM11_YEASTAIM11genetic
27708008
RAD4_YEASTRAD4genetic
27708008
SCM4_YEASTSCM4genetic
27708008
PUR4_YEASTADE6genetic
27708008
CHO2_YEASTCHO2genetic
27708008
ELP2_YEASTELP2genetic
27708008
INM1_YEASTINM1genetic
27708008
ACA2_YEASTCST6genetic
27708008
DCOR_YEASTSPE1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
ENT2_YEASTENT2genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
EFM7_YEASTNNT1genetic
27708008
COX8_YEASTCOX8genetic
27708008
ATP18_YEASTATP18genetic
27708008
CBPY_YEASTPRC1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
INO4_YEASTINO4genetic
27708008
VPS68_YEASTVPS68genetic
27708008
YO159_YEASTYOL159Cgenetic
27708008
CYC2_YEASTCYC2genetic
27708008
MCP1_YEASTMCP1genetic
27708008
PMT3_YEASTPMT3genetic
27708008
ALDH4_YEASTALD4genetic
27708008
HAT1_YEASTHAT1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
ALDH6_YEASTALD6genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
THI6_YEASTTHI6genetic
27708008
FMP40_YEASTFMP40genetic
27708008
SUE1_YEASTSUE1genetic
27708008
ICS2_YEASTICS2genetic
27708008
MET8_YEASTMET8genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
VPS41_YEASTVPS41genetic
27708008
ARX1_YEASTARX1genetic
27708008
APT2_YEASTAPT2genetic
27708008
CEM1_YEASTCEM1genetic
27708008
BMH1_YEASTBMH1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
HTD2_YEASTHTD2genetic
27708008
AIM18_YEASTAIM18genetic
27708008
BFA1_YEASTBFA1genetic
27708008
UBL1_YEASTYUH1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
FABG_YEASTOAR1genetic
27708008
MCR1_YEASTMCR1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
SEI1_YEASTFLD1genetic
27708008
MSH2_YEASTMSH2genetic
27708008
FABD_YEASTMCT1genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
NHP6A_YEASTNHP6Agenetic
27708008
YRA1_YEASTYRA1physical
26876600
MEX67_YEASTMEX67physical
26876600
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DBP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-90, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-90, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.

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