| UniProt ID | ACL4_YEAST | |
|---|---|---|
| UniProt AC | Q03771 | |
| Protein Name | Assembly chaperone of RPL4 {ECO:0000303|PubMed:25936803} | |
| Gene Name | ACL4 {ECO:0000303|PubMed:25936803} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 387 | |
| Subcellular Localization | Cytoplasm . Nucleus . Distributed throughout the cell but is enriched in the nucleus. | |
| Protein Description | Acts as a chaperone for the L4 ribosomal subunit encoded by RPL4A and PRPL4B, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.. | |
| Protein Sequence | MSELEATIRQAKEALAENNAKKALKILKPFKSSLKKENANNVILNEVFADAYLDNGQVEKAYPILARACELDPEGQVGGPDKFFTMGQIMGGQDGVSIITRGIMNISNTGGEMLTNVQVEKIVGGLLSVIEIWMTDLCMEPNAEEQCEELIQKAMELTEGKSPETWSTLGSIKISQQKFGEAYEAFSQAWNFFELKKQEIGSGINENGDTTQKAGLQSEYVDLLQPLLSLTKMCLEVGAYEVALKVIAAVRDIDEDNIEGYYLEGFTYYLMSKLEIFKLNNPEVSLRPENIYEFNQLIQEVPLDLSHEPISQLIYDSRLALSFALQAGVNADSKDEIVQELLGGANALLQEIGGPLDPSELTQIKKGDLVNENEDLEELDIEEEYSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSELEATIR ------CCHHHHHHH | 22814378 | ||
| 31 | Acetylation | LKILKPFKSSLKKEN HHHHHHHHHHCCHHC | 24489116 | ||
| 158 | Phosphorylation | IQKAMELTEGKSPET HHHHHHHHCCCCHHH | 24961812 | ||
| 162 | Phosphorylation | MELTEGKSPETWSTL HHHHCCCCHHHHHHH | 21440633 | ||
| 165 | Phosphorylation | TEGKSPETWSTLGSI HCCCCHHHHHHHCCC | 24961812 | ||
| 167 | Phosphorylation | GKSPETWSTLGSIKI CCCHHHHHHHCCCEE | 24961812 | ||
| 168 | Phosphorylation | KSPETWSTLGSIKIS CCHHHHHHHCCCEEC | 24961812 | ||
| 171 | Phosphorylation | ETWSTLGSIKISQQK HHHHHHCCCEECHHH | 24961812 | ||
| 210 | Phosphorylation | GINENGDTTQKAGLQ CCCCCCCCHHHCCCC | 30377154 | ||
| 211 | Phosphorylation | INENGDTTQKAGLQS CCCCCCCHHHCCCCH | 30377154 | ||
| 385 | Phosphorylation | ELDIEEEYSD----- HCCCCHHHCC----- | 29734811 | ||
| 386 | Phosphorylation | LDIEEEYSD------ CCCCHHHCC------ | 19795423 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACL4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACL4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACL4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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