XPT1_YEAST - dbPTM
XPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID XPT1_YEAST
UniProt AC P47165
Protein Name Xanthine phosphoribosyltransferase 1
Gene Name XPT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 209
Subcellular Localization Cytoplasm .
Protein Description May act as a xanthine phosphoribosyltransferase involved in the synthesis of purine nucleotides. Such activity is however unclear in vivo..
Protein Sequence MAENERMYISYNNIHKLCQGVAKHILARNERPDIIIAITGGGMIPARIIRSFLKTKGQKNIPIQAIGLSLYEDLGLDNSVETIGKEVIRTQWLDFGALNQHFDSLIGKKVLIVDEVDDTRTTLHYAVSELEKEIAEQQKVLNRMSEETVISIFVLHNKDKPKRAGLPDSMMNSGRYIAAQTVPDKWLCYPWDAEDIEEHTMLAKAQGHD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAENERMYISYNNIH
CCCCCCEEEEHHHHH		7.9228132839
11PhosphorylationNERMYISYNNIHKLC
CCCEEEEHHHHHHHH		11.5828132839
16AcetylationISYNNIHKLCQGVAK
EEHHHHHHHHHHHHH		47.3524489116
23AcetylationKLCQGVAKHILARNE
HHHHHHHHHHHHCCC		28.8624489116
79PhosphorylationEDLGLDNSVETIGKE
HHHCCCCCHHHHCHH		22.4628889911
132AcetylationYAVSELEKEIAEQQK
HHHHHHHHHHHHHHH		68.0224489116
169PhosphorylationKRAGLPDSMMNSGRY
CCCCCCHHHHHCCCE		20.2827017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of XPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of XPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of XPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XPT1_YEASTXPT1physical
18467557
PHSG_YEASTGPH1genetic
21623372
SRL2_YEASTSRL2genetic
27708008
INO4_YEASTINO4genetic
27708008
SNF5_YEASTSNF5genetic
27708008
HSP78_YEASTHSP78genetic
27708008
RV167_YEASTRVS167genetic
27708008
LSB3_YEASTLSB3genetic
27708008
SNF6_YEASTSNF6genetic
27708008
NAM8_YEASTNAM8genetic
27708008
IF4A_YEASTTIF2genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
FRE2_YEASTFRE2genetic
27708008
SYM1_YEASTSYM1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
GLRX8_YEASTGRX8genetic
27708008
YMS4_YEASTYMR034Cgenetic
27708008
SCS7_YEASTSCS7genetic
27708008
MSB4_YEASTMSB4genetic
27708008
RQC2_YEASTTAE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of XPT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND MASSSPECTROMETRY.

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