SRL2_YEAST - dbPTM
SRL2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRL2_YEAST
UniProt AC Q12020
Protein Name Protein SRL2
Gene Name SRL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 392
Subcellular Localization Cytoplasm . Nucleus .
Protein Description
Protein Sequence MSNFKNFTLNSFEDYYGKPSETPKMEEEKLEVTNVNASSSKKVHKSKKSTSKYDQKNVFRNSMTGIAQILPTKPVKIIEQNIDFANPKSFDLLQSTHTICFNKRINTTNTKLNVETHTSSDIDNDILHVGAPTDLGGNSNDEAETRQLRKFRWSNNKEKSLCEKLTVIYWALLLHTTKRASKRRPILCHQMIAEFFNRVYKEKSRVPITSRYIRDNLVAWVTQGKELHEKGWVGDAKTGDLQEQFNIATVKLYESAEDGRLSIGKDKPFREENTGSDSLVRAEEDSTAVTNENGHISSEKNLKKDRRESIRNQILTLDLNDEDFFQNVMKVLSAIDEPELRQYVIVISELVSMEMDDGKTVREKLRDVELNINRLQVDIKEIKEMLVTLINK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationFKNFTLNSFEDYYGK
CCCCCCCCHHHHCCC		32.8817563356
22PhosphorylationYYGKPSETPKMEEEK
HCCCCCCCCCCHHHH		32.3327214570
56AcetylationSTSKYDQKNVFRNSM
CCCHHHHHHHHHHCC		52.7825381059
62PhosphorylationQKNVFRNSMTGIAQI
HHHHHHHCCCCHHHH		17.2917563356
64PhosphorylationNVFRNSMTGIAQILP
HHHHHCCCCHHHHCC		25.8424961812
116PhosphorylationNTKLNVETHTSSDID
CCEEEEEEECCCCCC		26.6021440633
118PhosphorylationKLNVETHTSSDIDND
EEEEEEECCCCCCCC		37.0319779198
119PhosphorylationLNVETHTSSDIDNDI
EEEEEECCCCCCCCE		20.5721440633
120PhosphorylationNVETHTSSDIDNDIL
EEEEECCCCCCCCEE		39.4817563356
133PhosphorylationILHVGAPTDLGGNSN
EEEECCCCCCCCCCC		43.2428889911
139PhosphorylationPTDLGGNSNDEAETR
CCCCCCCCCCHHHHH		49.2721551504
145PhosphorylationNSNDEAETRQLRKFR
CCCCHHHHHHHHHHH		30.6628889911
255PhosphorylationATVKLYESAEDGRLS
EEEEEEECCCCCCCC		24.3330377154
262PhosphorylationSAEDGRLSIGKDKPF
CCCCCCCCCCCCCCC		28.1222369663
265AcetylationDGRLSIGKDKPFREE
CCCCCCCCCCCCCCC		61.9925381059
274PhosphorylationKPFREENTGSDSLVR
CCCCCCCCCCCCCEE		41.1428889911
278PhosphorylationEENTGSDSLVRAEED
CCCCCCCCCEEECCC		30.3828889911
298PhosphorylationNENGHISSEKNLKKD
CCCCCCCCCCCCCHH		52.5730377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRL2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRL2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRL2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRL2_YEASTSRL2physical
10688190
YH41B_YEASTYHL009W-Bphysical
16554755
ABF1_YEASTABF1physical
16554755
NOT2_YEASTCDC36genetic
17314980
CKS1_YEASTCKS1genetic
17314980
RPB3_YEASTRPB3genetic
17314980
SPT3_YEASTSPT3genetic
17314980
PFD1_YEASTPFD1genetic
17314980
PFD2_YEASTGIM4genetic
17314980
SRL2_YEASTSRL2physical
11283351
RTC1_YEASTRTC1physical
18467557
SRL2_YEASTSRL2physical
18719252
RMR1_YEASTRMR1physical
18719252
VPS64_YEASTVPS64physical
22875988
SPR3_YEASTSPR3physical
22875988
ETP1_YEASTETP1physical
22875988
SPA2_YEASTSPA2physical
22875988
SRL2_YEASTSRL2physical
22875988
NMT_YEASTNMT1physical
22875988
ARP3_YEASTARP3genetic
27708008
SHG1_YEASTSHG1genetic
27708008
BFA1_YEASTBFA1genetic
27708008
MPCP_YEASTMIR1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DGK1_YEASTDGK1genetic
27708008
SMT3_YEASTSMT3genetic
27708008
ACT_YEASTACT1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
TAD3_YEASTTAD3genetic
27708008
ROT1_YEASTROT1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
GEM1_YEASTGEM1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
STE50_YEASTSTE50genetic
27708008
HAC1_YEASTHAC1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
PTH_YEASTPTH1genetic
27708008
ACA2_YEASTCST6genetic
27708008
GSH1_YEASTGSH1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DCOR_YEASTSPE1genetic
27708008
ROM2_YEASTROM2genetic
27708008
UBC9_HUMANUBE2Iphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRL2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-139, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-62 AND SER-120,AND MASS SPECTROMETRY.

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