dbPTM

MSB4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSB4_YEAST
UniProt AC	Q12317
Protein Name	GTPase-activating protein MSB4
Gene Name	MSB4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	492
Subcellular Localization	Cytoplasm . Bud . Bud neck . Localizes to the presumptive bud site, the bud tip and the mother-bud neck.
Protein Description	Regulates exocytosis by functioning as a GAP for SEC4. Also required for efficient polarization of the actin patches..
Protein Sequence	MIMSSTMSTEAALVPNESVFDTVSSFNEDDANYSVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSLIMADPENFDRYGFSKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEEKAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVALGILKLSESEFLESKSQKLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEADMEILQVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQRASSRPKERRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
398	Phosphorylation	SQKLFRQYSSYTFGG HHHHHHHHHCCCCCC	8.70	27017623
412	Phosphorylation	GSNDSDSTFKRLKNK CCCCCHHHHHHHHHH	37.86	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSB4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSB4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSB4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPA2_YEAST	SPA2	physical	11489916
SPA2_YEAST	SPA2	physical	16166638
BNI1_YEAST	BNI1	physical	16166638
BUD6_YEAST	BUD6	physical	16166638
PEA2_YEAST	PEA2	physical	16166638
GYP3_YEAST	MSB3	genetic	10514570
SA155_YEAST	SAP155	genetic	16231214
SSZ1_YEAST	SSZ1	genetic	16231214
OSH2_YEAST	OSH2	genetic	17004323
KES1_YEAST	KES1	genetic	17004323
YPT6_YEAST	YPT6	physical	10937877
YPT7_YEAST	YPT7	physical	10937877
SEC4_YEAST	SEC4	physical	10937877
CIC1_YEAST	CIC1	genetic	16231214
USO1_YEAST	USO1	genetic	16231214
VPS35_YEAST	VPS35	genetic	16231214
SEC7_YEAST	SEC7	genetic	16231214
US6NL_HUMAN	USP6NL	genetic	14521938
PP2C1_YEAST	PTC1	genetic	23924898
FUN30_YEAST	FUN30	genetic	27708008
ACS1_YEAST	ACS1	genetic	27708008
PP2C4_YEAST	PTC4	genetic	27708008
ELO2_YEAST	ELO2	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
DOT1_YEAST	DOT1	genetic	27708008
ACA1_YEAST	ACA1	genetic	27708008
PHO4_YEAST	PHO4	genetic	27708008
MDM34_YEAST	MDM34	genetic	27708008
RL11B_YEAST	RPL11B	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
YG2W_YEAST	YGR111W	genetic	27708008
BNS1_YEAST	BNS1	genetic	27708008
SGN1_YEAST	SGN1	genetic	27708008
SDHX_YEAST	YJL045W	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
ANR2_YEAST	ANR2	genetic	27708008
YK03_YEAST	YKR023W	genetic	27708008
YL042_YEAST	YLR042C	genetic	27708008
RS28B_YEAST	RPS28B	genetic	27708008
UBP15_YEAST	UBP15	genetic	27708008
LCF1_YEAST	FAA1	genetic	27708008
YP089_YEAST	YPR089W	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSB4_YEAST

Related Literatures of Post-Translational Modification