| UniProt ID | CIC1_YEAST | |
|---|---|---|
| UniProt AC | P38779 | |
| Protein Name | Proteasome-interacting protein CIC1 | |
| Gene Name | CIC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 376 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth.. | |
| Protein Sequence | MAKKSNSKKSTPVSTPSKEKKKVIEKKSSTAIPRERVIKAVNELIKFTSKPQDENNEEGNNGKKNLLEDDEEELKKDLQLIVVNNKSFTGTSKSFKLKLLNVKHSFYKPWKEASATAVKDFKVLLILKDSDIKKVSEDDLFDQLDSEGIKVDEIICGKDLKTVYKAYEARNAFISQFSLILADDSIVTSLPKLMGGKAYNKVETTPISIRTHANKEFSLTTLTNNIKKVYMNQLPVKLPRGTTLNVHLGNLEWLRPEEFVDNVELISEQLIKAYQIRSIFIKTNRSPVLPLYYNQDVLDELEAKKDKIEETHEDDMVTIDGVQVHLSTFNKGLMEIANPSELGSIFSKQINNAKKRSSSELEKESSESEAVKKAKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAKKSNSKKSTP ---CCCCCCCCCCCC | 45.70 | 17563356 | |
| 7 | Phosphorylation | -MAKKSNSKKSTPVS -CCCCCCCCCCCCCC | 48.85 | 11875433 | |
| 10 | Phosphorylation | KKSNSKKSTPVSTPS CCCCCCCCCCCCCCC | 41.50 | 25521595 | |
| 11 | Phosphorylation | KSNSKKSTPVSTPSK CCCCCCCCCCCCCCH | 36.27 | 25521595 | |
| 14 | Phosphorylation | SKKSTPVSTPSKEKK CCCCCCCCCCCHHHH | 35.49 | 19823750 | |
| 15 | Phosphorylation | KKSTPVSTPSKEKKK CCCCCCCCCCHHHHH | 31.64 | 25521595 | |
| 17 | Phosphorylation | STPVSTPSKEKKKVI CCCCCCCCHHHHHHH | 54.24 | 22890988 | |
| 18 | Acetylation | TPVSTPSKEKKKVIE CCCCCCCHHHHHHHH | 74.81 | 25381059 | |
| 39 | Acetylation | IPRERVIKAVNELIK CCHHHHHHHHHHHHH | 43.34 | 24489116 | |
| 340 | Phosphorylation | LMEIANPSELGSIFS HHHCCCHHHHHHHHH | 45.31 | 30377154 | |
| 344 | Phosphorylation | ANPSELGSIFSKQIN CCHHHHHHHHHHHHH | 32.84 | 30377154 | |
| 348 | Acetylation | ELGSIFSKQINNAKK HHHHHHHHHHHHHHH | 44.44 | 24489116 | |
| 357 | Phosphorylation | INNAKKRSSSELEKE HHHHHHCCHHHHHHH | 47.28 | 17563356 | |
| 358 | Phosphorylation | NNAKKRSSSELEKES HHHHHCCHHHHHHHC | 31.68 | 27214570 | |
| 359 | Phosphorylation | NAKKRSSSELEKESS HHHHCCHHHHHHHCH | 47.66 | 17563356 | |
| 365 | Phosphorylation | SSELEKESSESEAVK HHHHHHHCHHHHHHH | 50.93 | 17330950 | |
| 366 | Phosphorylation | SELEKESSESEAVKK HHHHHHCHHHHHHHH | 46.35 | 25521595 | |
| 368 | Phosphorylation | LEKESSESEAVKKAK HHHHCHHHHHHHHHC | 32.57 | 28889911 | |
| 372 | Acetylation | SSESEAVKKAKS--- CHHHHHHHHHCC--- | 54.80 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CIC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CIC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CIC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; THR-11; SER-359 ANDSER-366, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-7; SER-10;THR-11; SER-14; THR-15; SER-357; SER-359 AND SER-366, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND THR-11, AND MASSSPECTROMETRY. | |
