NOP4_YEAST - dbPTM
NOP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOP4_YEAST
UniProt AC P37838
Protein Name Nucleolar protein 4
Gene Name NOP4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 685
Subcellular Localization Nucleus, nucleolus.
Protein Description Required for 60S ribosomal subunit synthesis. Probably involved in the processing of 27S rRNA to produce mature 25S rRNA..
Protein Sequence MEETIENVEVPSSNVSKQNDDGLDMKTLFVRSIPQDVTDEQLADFFSNFAPIKHAVVVKDTNKRSRGFGFVSFAVEDDTKEALAKARKTKFNGHILRVDIAKRRDRSKKTSEVVEKSTPESSEKITGQNNEDEDDADGEDSMLKGKPKLIIRNMPWSCRDPVKLKKIFGRYGTVVEATIPRKRDGKLCGFAFVTMKKISNCRIALENTKDLKIDGRKVAVDFAVQKNRWEDYKKAQPEMNDKDDNESGNEDAEENHDDEEDENEEEDRQVDQASKNKESKRKAQNKREDFSVFVRNVPYDATEESLAPHFSKFGSVKYALPVIDKSTGLAKGTAFVAFKDQYTYNECIKNAPAAGSTSLLIGDDVMPEYVYEGRVLSITPTLVREDAGRMAEKNAAKRKEALGKAPGEKDRRNLYLLNEGRVVEGSKMADLLTNTDMEIREKSYKLRVEQLKKNPSLHLSMTRLAIRNLPRAMNDKALKALARKAVVEFATEVKNKERHPLSKEEIIRSTKEKYKFMGPDEIEAQKKKDKKSGVVKQAKVIMEVKGSTAGRSRGYGFVEFRDHKNALMGLRWLNCHAVTSDEILEGLNDDEKKQVDNDLGKGRRLCVEFAIENSNVVKRRREQLKQARTKRTRPDNEDTGDVGESENKKPKKEEATTPTNPDDKKMGDDIKRIIGFKRKRKHAKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26AcetylationNDDGLDMKTLFVRSI
CCCCCCHHEEEEEEC		41.5724489116
53UbiquitinationFSNFAPIKHAVVVKD
HHHCCCCCEEEEEEC		25.1817644757
117PhosphorylationTSEVVEKSTPESSEK
HHHHHHHCCCCCCCC		35.3723749301
118PhosphorylationSEVVEKSTPESSEKI
HHHHHHCCCCCCCCC		41.9923749301
141PhosphorylationDDADGEDSMLKGKPK
CCCCCCCCCCCCCCE		23.0123749301
144AcetylationDGEDSMLKGKPKLII
CCCCCCCCCCCEEEE		57.1323572591
173PhosphorylationKIFGRYGTVVEATIP
HHHHCCCCEEEEEEC		16.6728889911
196AcetylationGFAFVTMKKISNCRI
EEEEEEEEECCCCEE		37.2725381059
197AcetylationFAFVTMKKISNCRIA
EEEEEEEECCCCEEE		40.3125381059
217UbiquitinationDLKIDGRKVAVDFAV
CCEECCEEEEEEHHH		39.8215699485
226UbiquitinationAVDFAVQKNRWEDYK
EEEHHHHCCCHHHHH		41.7115699485
247PhosphorylationNDKDDNESGNEDAEE
CCCCCCCCCCCCHHH		53.8525521595
274PhosphorylationDRQVDQASKNKESKR
HHHHHHHHHCHHHHH		31.0029136822
312AcetylationSLAPHFSKFGSVKYA
HHHHHHHHHCCEEEE		53.4524489116
312UbiquitinationSLAPHFSKFGSVKYA
HHHHHHHHHCCEEEE		53.4515699485
317UbiquitinationFSKFGSVKYALPVID
HHHHCCEEEEEEEEE		26.8815699485
317AcetylationFSKFGSVKYALPVID
HHHHCCEEEEEEEEE		26.8824489116
325AcetylationYALPVIDKSTGLAKG
EEEEEEECCCCCCCC		38.5024489116
325UbiquitinationYALPVIDKSTGLAKG
EEEEEEECCCCCCCC		38.5023749301
349UbiquitinationYTYNECIKNAPAAGS
EEHHHHHHCCCCCCC		59.7317644757
377PhosphorylationVYEGRVLSITPTLVR
EEECEEEEECCCCHH		22.8928889911
379PhosphorylationEGRVLSITPTLVRED
ECEEEEECCCCHHHH		13.5715665377
444PhosphorylationMEIREKSYKLRVEQL
HHHHHHHHHHHHHHH		25.7221126336
479AcetylationAMNDKALKALARKAV
HCCHHHHHHHHHHHH		46.3325381059
564UbiquitinationFVEFRDHKNALMGLR
EEEECCCCCHHHHHH		48.4817644757
656PhosphorylationKPKKEEATTPTNPDD
CCCCCCCCCCCCCCH		36.2729136822
657PhosphorylationPKKEEATTPTNPDDK
CCCCCCCCCCCCCHH		34.8525521595
659PhosphorylationKEEATTPTNPDDKKM
CCCCCCCCCCCHHCC		58.2425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOP4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRX1_YEASTBRX1physical
11805826
DBP9_YEASTDBP9physical
11805826
DRS1_YEASTDRS1physical
11805826
ERB1_YEASTERB1physical
11805826
HAS1_YEASTHAS1physical
11805826
NAT10_YEASTKRE33physical
11805826
NOG1_YEASTNOG1physical
11805826
NOP12_YEASTNOP12physical
11805826
NOP2_YEASTNOP2physical
11805826
RLP7_YEASTRLP7physical
11805826
NOP56_YEASTNOP56physical
11805826
UTP20_YEASTUTP20physical
11805826
MAK21_YEASTMAK21physical
11805826
PUF6_YEASTPUF6physical
11805826
NUG1_YEASTNUG1physical
11805826
PESC_YEASTNOP7physical
11805826
CIC1_YEASTCIC1physical
11805826
UTP10_YEASTUTP10physical
11805826
URB1_YEASTURB1physical
11805826
MDN1_YEASTMDN1physical
11805826
NOC2_YEASTNOC2physical
11805826
RRP12_YEASTRRP12physical
11805826
YTM1_YEASTYTM1physical
11805826
HAS1_YEASTHAS1physical
12150911
NAT10_YEASTKRE33physical
12150911
NOP56_YEASTNOP56physical
12150911
RRP12_YEASTRRP12physical
12150911
RRP5_YEASTRRP5physical
12150911
UTP20_YEASTUTP20physical
12150911
FBRL_YEASTNOP1genetic
9372940
NAT10_YEASTKRE33physical
16429126
NOP12_YEASTNOP12physical
16429126
RL2A_YEASTRPL2Aphysical
16429126
RL2B_YEASTRPL2Aphysical
16429126
RL6B_YEASTRPL6Bphysical
16429126
RRP5_YEASTRRP5physical
16429126
NOP56_YEASTNOP56physical
16429126
UTP10_YEASTUTP10physical
16429126
UTP20_YEASTUTP20physical
16429126
BRX1_YEASTBRX1physical
16429126
CIC1_YEASTCIC1physical
16429126
DBP9_YEASTDBP9physical
16429126
DRS1_YEASTDRS1physical
16429126
HAS1_YEASTHAS1physical
16429126
NOG1_YEASTNOG1physical
16429126
NOP2_YEASTNOP2physical
16429126
NUG1_YEASTNUG1physical
16429126
PUF6_YEASTPUF6physical
16429126
RLP7_YEASTRLP7physical
16429126
RL25_YEASTRPL25physical
16429126
RL3_YEASTRPL3physical
16429126
RL7B_YEASTRPL7Bphysical
16429126
RL8B_YEASTRPL8Bphysical
16429126
YTM1_YEASTYTM1physical
16429126
ERB1_YEASTERB1physical
16429126
MAK21_YEASTMAK21physical
16429126
NOC2_YEASTNOC2physical
16429126
PESC_YEASTNOP7physical
16429126
RL18A_YEASTRPL18Aphysical
16429126
RL18B_YEASTRPL18Aphysical
16429126
RRP12_YEASTRRP12physical
16429126
RL4A_YEASTRPL4Aphysical
16429126
XRN1_YEASTXRN1physical
16429126
RL27A_YEASTRPL27Aphysical
16429126
RL16A_YEASTRPL16Aphysical
16429126
RL5_YEASTRPL5physical
16429126
MDN1_YEASTMDN1physical
16429126
LOC1_YEASTLOC1physical
25877921
NOP4_YEASTNOP4physical
25877921
EBP2_YEASTEBP2physical
25877921
MAK21_YEASTMAK21physical
25877921
SWC5_YEASTSWC5genetic
27708008
SAC3_YEASTSAC3genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
CTK1_YEASTCTK1genetic
27708008
ENV10_YEASTENV10genetic
27708008
ALAM_YEASTALT1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
MAK16_YEASTMAK16genetic
27708008
MAK5_YEASTMAK5genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPN5_YEASTRPN5genetic
27708008
DAD1_YEASTDAD1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
ERF3_YEASTSUP35genetic
27708008
RSP5_YEASTRSP5genetic
27708008
PRP43_YEASTPRP43genetic
27708008
PESC_YEASTNOP7genetic
27708008
RRP41_YEASTSKI6genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
UTP9_YEASTUTP9genetic
27708008
MET30_YEASTMET30genetic
27708008
EXO70_YEASTEXO70genetic
27708008
KTHY_YEASTCDC8genetic
27708008
MAK11_YEASTMAK11genetic
27708008
RRN3_YEASTRRN3genetic
27708008
DBP9_YEASTDBP9genetic
27708008
RU1C_YEASTYHC1genetic
27708008
POB3_YEASTPOB3genetic
27708008
RLP7_YEASTRLP7genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RRP44_YEASTDIS3genetic
27708008
BRX1_YEASTBRX1genetic
27708008
HRP1_YEASTHRP1genetic
27708008
GRPE_YEASTMGE1genetic
27708008
DYR_YEASTDFR1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CSG2_YEASTCSG2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
ODPA_YEASTPDA1genetic
27708008
PUF4_YEASTPUF4genetic
27708008
DBP3_YEASTDBP3genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
PIH1_YEASTPIH1genetic
27708008
SSF1_YEASTSSF1genetic
27708008
OSH3_YEASTOSH3genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIR1_YEASTAIR1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
SRP40_YEASTSRP40genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
SWI6_YEASTSWI6genetic
27708008
RSA3_YEASTRSA3genetic
27708008
ECM22_YEASTECM22genetic
27708008
SST2_YEASTSST2genetic
27708008
TMA23_YEASTTMA23genetic
27708008
DOM34_YEASTDOM34genetic
27708008
SPO1_YEASTSPO1genetic
27708008
MDM12_YEASTMDM12genetic
27708008
NOP12_YEASTNOP12genetic
27708008
REXO4_YEASTREX4genetic
27708008
IRA2_YEASTIRA2genetic
27708008
RRP6_YEASTRRP6genetic
27708008
NOP4_YEASTNOP4physical
27077951
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOP4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; THR-118 ANDTHR-173, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-379, AND MASSSPECTROMETRY.

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