RL27A_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL27A_YEAST
• UniProt AC: P0C2H6
• Protein Name: 60S ribosomal protein L27-A {ECO:0000303|PubMed:9559554}
• Gene Name: RPL27A {ECO:0000303|PubMed:9559554}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 136
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
• Protein Sequence: MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHALVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKVVNYNHLLPTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEERHQAGKNQWFFSKLRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	2-Hydroxyisobutyrylation	--MAKFLKAGKVAVV --CCHHHHCCCEEEE	59.22	-
6	Ubiquitination	--MAKFLKAGKVAVV --CCHHHHCCCEEEE	59.22	22817900
9	Ubiquitination	AKFLKAGKVAVVVRG CHHHHCCCEEEEEEC	31.70	23749301
21	Ubiquitination	VRGRYAGKKVVIVKP EECEECCCEEEEEEC	33.93	22817900
22	Ubiquitination	RGRYAGKKVVIVKPH ECEECCCEEEEEECC	40.59	23749301
27	Acetylation	GKKVVIVKPHDEGSK CCEEEEEECCCCCCC	26.05	24489116
27	Ubiquitination	GKKVVIVKPHDEGSK CCEEEEEECCCCCCC	26.05	23749301
33	Phosphorylation	VKPHDEGSKSHPFGH EECCCCCCCCCCCCE	29.01	21440633
34	Ubiquitination	KPHDEGSKSHPFGHA ECCCCCCCCCCCCEE	64.74	23749301
35	Phosphorylation	PHDEGSKSHPFGHAL CCCCCCCCCCCCEEH	37.78	22369663
52	Acetylation	GIERYPLKVTKKHGA CHHHCCCCCCHHHCC	43.27	25381059
54	Phosphorylation	ERYPLKVTKKHGAKK HHCCCCCCHHHCCHH	32.56	24961812
64	Ubiquitination	HGAKKVAKRTKIKPF HCCHHHHHHHCCCCE	64.68	22817900
67	Ubiquitination	KKVAKRTKIKPFIKV HHHHHHHCCCCEEEE	53.41	23749301
69	Ubiquitination	VAKRTKIKPFIKVVN HHHHHCCCCEEEEEE	35.12	22817900
69	2-Hydroxyisobutyrylation	VAKRTKIKPFIKVVN HHHHHCCCCEEEEEE	35.12	-
73	Acetylation	TKIKPFIKVVNYNHL HCCCCEEEEEECCCC	40.27	24489116
73	Ubiquitination	TKIKPFIKVVNYNHL HCCCCEEEEEECCCC	40.27	22817900
77	Phosphorylation	PFIKVVNYNHLLPTR CEEEEEECCCCCCCE	7.73	21082442
83	Phosphorylation	NYNHLLPTRYTLDVE ECCCCCCCEEEEEHH	35.96	21440633
85	Phosphorylation	NHLLPTRYTLDVEAF CCCCCCEEEEEHHHH	17.71	28889911
93	Ubiquitination	TLDVEAFKSVVSTET EEEHHHHHHHHCCCC	49.76	23749301
93	Acetylation	TLDVEAFKSVVSTET EEEHHHHHHHHCCCC	49.76	24489116
94	Phosphorylation	LDVEAFKSVVSTETF EEHHHHHHHHCCCCC	22.69	22369663
97	Phosphorylation	EAFKSVVSTETFEQP HHHHHHHCCCCCCCH	20.54	22369663
98	Phosphorylation	AFKSVVSTETFEQPS HHHHHHCCCCCCCHH	27.69	22369663
100	Phosphorylation	KSVVSTETFEQPSQR HHHHCCCCCCCHHHH	32.34	22369663
105	Phosphorylation	TETFEQPSQREEAKK CCCCCCHHHHHHHHH	41.38	22369663
111	Ubiquitination	PSQREEAKKVVKKAF HHHHHHHHHHHHHHH	49.75	22817900
111	Acetylation	PSQREEAKKVVKKAF HHHHHHHHHHHHHHH	49.75	24489116
111	Succinylation	PSQREEAKKVVKKAF HHHHHHHHHHHHHHH	49.75	23954790
112	Ubiquitination	SQREEAKKVVKKAFE HHHHHHHHHHHHHHH	60.35	22817900
115	Ubiquitination	EEAKKVVKKAFEERH HHHHHHHHHHHHHHH	41.18	22817900
116	Ubiquitination	EAKKVVKKAFEERHQ HHHHHHHHHHHHHHH	46.85	22817900
126	Ubiquitination	EERHQAGKNQWFFSK HHHHHCCCCCCHHHC	49.32	23749301
126	Succinylation	EERHQAGKNQWFFSK HHHHHCCCCCCHHHC	49.32	23954790
126	Acetylation	EERHQAGKNQWFFSK HHHHHCCCCCCHHHC	49.32	24489116
132	Phosphorylation	GKNQWFFSKLRF--- CCCCCHHHCCCC---	22.70	21440633
133	Ubiquitination	KNQWFFSKLRF---- CCCCHHHCCCC----	38.23	23749301
133	Methylation	KNQWFFSKLRF---- CCCCHHHCCCC----	38.23	20137074
133	Acetylation	KNQWFFSKLRF---- CCCCHHHCCCC----	38.23	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL27A_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL27A_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL27A_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL36A_YEAST	RPL36A	genetic	29158977
DOM34_YEAST	DOM34	genetic	29158977

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.