UTP10_YEAST - dbPTM
UTP10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UTP10_YEAST
UniProt AC P42945
Protein Name U3 small nucleolar RNA-associated protein 10
Gene Name UTP10
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1769
Subcellular Localization Nucleus, nucleolus. Mitochondrion. Associated with ribosomal chromatin, even in the absence of transcription.
Protein Description Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Involved in ribosome biosynthesis..
Protein Sequence MSSLSDQLAQVASNNATVALDRKRRQKLHSASLIYNSKTAATQDYDFIFENASKALEELSQIEPKFAIFSRTLFSESSISLDRNVQTKEEIKDLDNAINAYLLLASSKWYLAPTLHATEWLVRRFQIHVKNTEMLLLSTLNYYQTPVFKRILSIIKLPPLFNCLSNFVRSEKPPTALTMIKLFNDMDFLKLYTSYLDQCIKHNATYTNQLLFTTCCFINVVAFNSNNDEKLNQLVPILLEISAKLLASKSKDCQIAAHTILVVFATALPLKKTIILAAMETILSNLDAKEAKHSALLTICKLFQTLKGQGNVDQLPSKIFKLFDSKFDTVSILTFLDKEDKPVCDKFITSYTRSIARYDRSKLNIILSLLKKIRLERYEVRLIITDLIYLSEILEDKSQLVELFEYFISINEDLVLKCLKSLGLTGELFEIRLTTSLFTNADVNTDIVKQLSDPVETTKKDTASFQTFLDKHSELINTTNVSMLTETGERYKKVLSLFTEAIGKGYKASSFLTSFFTTLESRITFLLRVTISPAAPTALKLISLNNIAKYINSIEKEVNIFTLVPCLICALRDASIKVRTGVKKILSLIAKRPSTKHYFLSDKLYGENVTIPMLNPKDSEAWLSGFLNEYVTENYDISRILTPKRNEKVFLMFWANQALLIPSPYAKTVLLDNLNKSPTYASSYSSLFEEFISHYLENRSSWEKSCIANKTNFEHFERSLVNLVSPKEKQSFMIDFVLSALNSDYEQLANIAAERLISIFASLNNAQKLKIVQNIVDSSSNVESSYDTVGVLQSLPLDSDIFVSILNQNSISNEMDQTDFSKRRRRRSSTSKNAFLKEEVSQLAELHLRKLTIILEALDKVRNVGSEKLLFTLLSLLSDLETLDQDGGLPVLYAQETLISCTLNTITYLKEHGCTELTNVRADILVSAIRNSASPQVQNKLLLVIGSLATLSSEVILHSVMPIFTFMGAHSIRQDDEFTTKVVERTILTVVPALIKNSKGNEKEEMEFLLLSFTTALQHVPRHRRVKLFSTLIKTLDPVKALGSFLFLIAQQYSSALVNFKIGEARILIEFIKALLVDLHVNEELSGLNDLLDIIKLLTSSKSSSEKKKSLESRVLFSNGVLNFSESEFLTFMNNTFEFINKITEETDQDYYDVRRNLRLKVYSVLLDETSDKKLIRNIREEFGTLLEGVLFFINSVELTFSCITSQENEEASDSETSLSDHTTEIKEILFKVLGNVLQILPVDEFVNAVLPLLSTSTNEDIRYHLTLVIGSKFELEGSEAIPIVNNVMKVLLDRMPLESKSVVISQVILNTMTALVSKYGKKLEGSILTQALTLATEKVSSDMTEVKISSLALITNCVQVLGVKSIAFYPKIVPPSIKLFDASLADSSNPLKEQLQVAILLLFAGLIKRIPSFLMSNILDVLHVIYFSREVDSSIRLSVISLIIENIDLKEVLKVLFRIWSTEIATSNDTVAVSLFLSTLESTVENIDKKSATSQSPIFFKLLLSLFEFRSISSFDNNTISRIEASVHEISNSYVLKMNDKVFRPLFVILVRWAFDGEGVTNAGITETERLLAFFKFFNKLQENLRGIITSYFTYLLEPVDMLLKRFISKDMENVNLRRLVINSLTSSLKFDRDEYWKSTSRFELISVSLVNQLSNIENSIGKYLVKAIGALASNNSGVDEHNQILNKLIVEHMKASCSSNEKLWAIRAMKLIYSKIGESWLVLLPQLVPVIAELLEDDDEEIEREVRTGLVKVVENVLGEPFDRYLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSLSDQLA
------CCCHHHHHH		51.8222814378
2Phosphorylation------MSSLSDQLA
------CCCHHHHHH		51.8230377154
3Phosphorylation-----MSSLSDQLAQ
-----CCCHHHHHHH		43.6930377154
5Phosphorylation---MSSLSDQLAQVA
---CCCHHHHHHHHH		25.8430377154
13PhosphorylationDQLAQVASNNATVAL
HHHHHHHHCCCHHHC		31.5930377154
72PhosphorylationKFAIFSRTLFSESSI
HHHHHCCCCCCCCCC		30.8421126336
75PhosphorylationIFSRTLFSESSISLD
HHCCCCCCCCCCCCC		39.4230377154
77PhosphorylationSRTLFSESSISLDRN
CCCCCCCCCCCCCCC		31.6028889911
78PhosphorylationRTLFSESSISLDRNV
CCCCCCCCCCCCCCC		16.4919779198
318AcetylationNVDQLPSKIFKLFDS
CHHHCCHHHHHHHCC		50.6624489116
346AcetylationEDKPVCDKFITSYTR
CCCCHHHHHHHHHHH		33.2722865919
434PhosphorylationELFEIRLTTSLFTNA
EEEEEEECCHHCCCC		12.4222890988
435PhosphorylationLFEIRLTTSLFTNAD
EEEEEECCHHCCCCC		28.2022890988
436PhosphorylationFEIRLTTSLFTNADV
EEEEECCHHCCCCCC		19.0922890988
439PhosphorylationRLTTSLFTNADVNTD
EECCHHCCCCCCCCH		34.4922890988
445PhosphorylationFTNADVNTDIVKQLS
CCCCCCCCHHHHHHC		27.2722890988
452PhosphorylationTDIVKQLSDPVETTK
CHHHHHHCCCCCCCC		37.0622890988
457PhosphorylationQLSDPVETTKKDTAS
HHCCCCCCCCCCHHH		44.1222890988
458PhosphorylationLSDPVETTKKDTASF
HCCCCCCCCCCHHHH		23.6922890988
499PhosphorylationKKVLSLFTEAIGKGY
HHHHHHHHHHHCCCC		29.7827017623
676UbiquitinationVLLDNLNKSPTYASS
HHHHCCCCCCCCHHH		62.0617644757
841PhosphorylationAFLKEEVSQLAELHL
HHHHHHHHHHHHHHH		23.8230377154
981AcetylationQDDEFTTKVVERTIL
CCCHHHHHHHHHHHH		41.0224489116
1027AcetylationVPRHRRVKLFSTLIK
CCCHHHHHHHHHHHH		41.8424489116
1173AcetylationLLDETSDKKLIRNIR
HCCCCCCHHHHHHHH		49.6124489116
1372AcetylationKSIAFYPKIVPPSIK
CCEECCCCCCCCCCC		44.9824489116
1435PhosphorylationFSREVDSSIRLSVIS
HCCCCCCHHHHHHHH		13.7819779198
1625PhosphorylationLRRLVINSLTSSLKF
HHHHHHHHHHHCCCC		23.1519823750
1627PhosphorylationRLVINSLTSSLKFDR
HHHHHHHHHCCCCCH		18.9819823750
1628PhosphorylationLVINSLTSSLKFDRD
HHHHHHHHCCCCCHH		38.6819823750
1629PhosphorylationVINSLTSSLKFDRDE
HHHHHHHCCCCCHHH		30.2819823750
1689AcetylationEHNQILNKLIVEHMK
HHHHHHHHHHHHHHH		35.8224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UTP10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UTP10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UTP10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UTP8_YEASTUTP8physical
14759368
UTP9_YEASTUTP9physical
14759368
DPO5_YEASTPOL5physical
14759368
UTP17_YEASTNAN1physical
14759368
UTP4_YEASTUTP4physical
14759368
UTP15_YEASTUTP15physical
14759368
UTP10_YEASTUTP10physical
14759368
UTP5_YEASTUTP5physical
14759368
UTP17_YEASTNAN1physical
12150911
NOP58_YEASTNOP58physical
12150911
PWP2_YEASTPWP2physical
12150911
RRP9_YEASTRRP9physical
12150911
MPP10_YEASTMPP10physical
12068309
UTP4_YEASTUTP4physical
12150911
UTP6_YEASTUTP6physical
12150911
UTP22_YEASTUTP22physical
12150911
UTP8_YEASTUTP8physical
12150911
UTP9_YEASTUTP9physical
12150911
BMS1_YEASTBMS1physical
12150911
NEP1_YEASTEMG1physical
12150911
IMP3_YEASTIMP3physical
12150911
MPP10_YEASTMPP10physical
12150911
FBRL_YEASTNOP1physical
12150911
NOP56_YEASTNOP56physical
12150911
RL10_YEASTRPL10physical
12150911
RL22A_YEASTRPL22Aphysical
12150911
RL4A_YEASTRPL4Aphysical
12150911
RS13_YEASTRPS13physical
12150911
RS17A_YEASTRPS17Aphysical
12150911
RS17B_YEASTRPS17Bphysical
12150911
RS3A1_YEASTRPS1Aphysical
12150911
RS22A_YEASTRPS22Aphysical
12150911
RS4A_YEASTRPS4Aphysical
12150911
RS4B_YEASTRPS4Aphysical
12150911
RRP5_YEASTRRP5physical
12150911
DCA13_YEASTSOF1physical
12150911
UTP20_YEASTUTP20physical
12150911
UTP10_YEASTUTP10physical
12150911
UTP13_YEASTUTP13physical
12150911
UTP21_YEASTUTP21physical
12150911
UTP15_YEASTUTP15physical
12150911
YRA1_YEASTYRA1physical
16554755
UTP5_YEASTUTP5physical
16554755
DPO5_YEASTPOL5physical
16554755
RS26B_YEASTRPS26Bphysical
16554755
UTP9_YEASTUTP9physical
16554755
MPP10_YEASTMPP10physical
16554755
STM1_YEASTSTM1physical
16554755
UTP15_YEASTUTP15physical
16554755
RRS1_YEASTRRS1physical
16554755
UTP17_YEASTNAN1physical
16554755
BMS1_YEASTBMS1physical
16429126
NEP1_YEASTEMG1physical
16429126
IMP3_YEASTIMP3physical
16429126
MPP10_YEASTMPP10physical
16429126
FBRL_YEASTNOP1physical
16429126
NOP58_YEASTNOP58physical
16429126
PWP2_YEASTPWP2physical
16429126
RS13_YEASTRPS13physical
16429126
RS4A_YEASTRPS4Aphysical
16429126
RS4B_YEASTRPS4Aphysical
16429126
RRP9_YEASTRRP9physical
16429126
UTP13_YEASTUTP13physical
16429126
UTP21_YEASTUTP21physical
16429126
UTP22_YEASTUTP22physical
16429126
UTP6_YEASTUTP6physical
16429126
UTP7_YEASTUTP7physical
16429126
UTP17_YEASTNAN1physical
16429126
UTP15_YEASTUTP15physical
16429126
UTP4_YEASTUTP4physical
16429126
UTP8_YEASTUTP8physical
16429126
UTP9_YEASTUTP9physical
16429126
RS22A_YEASTRPS22Aphysical
16429126
RRP5_YEASTRRP5physical
16429126
NOP56_YEASTNOP56physical
16429126
DCA13_YEASTSOF1physical
16429126
UTP20_YEASTUTP20physical
16429126
RS3A1_YEASTRPS1Aphysical
16429126
RS17B_YEASTRPS17Bphysical
16429126
RL4A_YEASTRPL4Aphysical
16429126
HAS1_YEASTHAS1physical
16449635
HSC82_YEASTHSC82physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
UTP5_YEASTUTP5physical
20385600
UTP15_YEASTUTP15physical
20385600
UTP17_YEASTNAN1physical
20385600
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UTP10_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASSSPECTROMETRY.

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