SSF2_YEAST - dbPTM
SSF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SSF2_YEAST
UniProt AC Q12153
Protein Name Ribosome biogenesis protein SSF2
Gene Name SSF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 453
Subcellular Localization Nucleus, nucleolus .
Protein Description Required for biogenesis of the 60S ribosomal subunit..
Protein Sequence MAKRRQKKRTHAQITPEQERDIPKSMVIRVGQTSLANHSLNQLVKDFRQIMQPHTAVKLKERKSNKLKDFVVMCGPLGVTHLFMFTQSEKTGNVSLKIARTPQGPTVTFQVLDYSLGRDIKKFLKRPKSLNNDDVLNPPLLVLNGFSTSKRSDEDDQDVNVEKVIVSMFQNIFPPLNPARTSLNSIKRIFMINKDRETGEISMRHYFIDIREVEISRNLKRLYKAKNNLSKTVPNLHRKEDISSLILDHDLGAYTSESEIEDDAIVRVVDNQDVKAKHSQTSLSQKTPVKMTDNEEREKGIEEEDVEMEEPKPSENSQPTPRKKAIKLTELGPRLTLKLVKIEDGICSGKVLHHEFVQKSSEEIKALEKRHAAKMRLKEQRRKEQEENIAKKKAVKDAKKQRKLERRKARAEEQGEGQGKDGAMSDDGSSSSEDEHYSDVPEDLDSDLFSEVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationKRTHAQITPEQERDI
CCCCCCCCHHHHCCC		14.5329136822
45UbiquitinationHSLNQLVKDFRQIMQ
CCHHHHHHHHHHHHC		60.7917644757
243PhosphorylationLHRKEDISSLILDHD
CCCCCCHHHHHHCCC		31.2619779198
244PhosphorylationHRKEDISSLILDHDL
CCCCCHHHHHHCCCC		21.5519779198
254PhosphorylationLDHDLGAYTSESEIE
HCCCCCCCCCCCCCC		14.7017330950
255PhosphorylationDHDLGAYTSESEIED
CCCCCCCCCCCCCCC		26.0319795423
256PhosphorylationHDLGAYTSESEIEDD
CCCCCCCCCCCCCCC		26.8417330950
258PhosphorylationLGAYTSESEIEDDAI
CCCCCCCCCCCCCCE		43.5717330950
279PhosphorylationQDVKAKHSQTSLSQK
CCHHHHHCCCCCCCC		34.1528889911
281PhosphorylationVKAKHSQTSLSQKTP
HHHHHCCCCCCCCCC		34.3523749301
286AcetylationSQTSLSQKTPVKMTD
CCCCCCCCCCCCCCC		51.9625381059
287PhosphorylationQTSLSQKTPVKMTDN
CCCCCCCCCCCCCCH		26.1921440633
329PhosphorylationRKKAIKLTELGPRLT
CHHHHHHHCCCCCEE		24.9423749301
350UbiquitinationEDGICSGKVLHHEFV
CCCCCCCCCCCHHHH		25.9015699485
359UbiquitinationLHHEFVQKSSEEIKA
CCHHHHHCCHHHHHH		51.1215699485
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SSF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SSF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SSF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RSA3_YEASTRSA3genetic
19061648
IF4F1_YEASTTIF4631genetic
19061648
NU159_YEASTNUP159genetic
19061648
SSF1_YEASTSSF1genetic
19061648
IMB1_YEASTKAP95genetic
19061648
MGR1_YEASTMGR1genetic
20093466
RM01_YEASTMRPL1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
SMI1_YEASTSMI1genetic
20093466
YOR1_YEASTYOR1genetic
20093466
NPR3_YEASTNPR3genetic
20093466
SSF1_YEASTSSF1genetic
20093466
CTF8_YEASTCTF8genetic
20093466
URM1_YEASTURM1genetic
20093466
ELO3_YEASTELO3genetic
20093466
SCS7_YEASTSCS7genetic
20093466
SWS2_YEASTSWS2genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
ATP23_YEASTATP23genetic
20093466
MNE1_YEASTMNE1genetic
20093466
SKM1_YEASTSKM1physical
22940862
RRP15_YEASTRRP15physical
25877921
EBP2_YEASTEBP2physical
25877921
HMI1_YEASTHMI1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RIM1_YEASTRIM1genetic
27708008
ATG15_YEASTATG15genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GET1_YEASTGET1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
SMI1_YEASTSMI1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
MED20_YEASTSRB2genetic
27708008
SSF1_YEASTSSF1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
URM1_YEASTURM1genetic
27708008
ELO3_YEASTELO3genetic
27708008
ATP10_YEASTATP10genetic
27708008
MSS1_YEASTMSS1genetic
27708008
SAP30_YEASTSAP30genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
ODP2_YEASTLAT1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
SIN3_YEASTSIN3genetic
27708008
MNE1_YEASTMNE1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SSF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-254; SER-256 ANDSER-258, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.

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