ICS2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICS2_YEAST
• UniProt AC: P38284
• Protein Name: Increased copper sensitivity protein 2
• Gene Name: ICS2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 255
• Protein Sequence: MGKFEQKERERISTFSFPTTGSQSSTSIKSLGSPLYGRFSSLSSTESQFDSSKQPHEYEKSFYFEESQGEALFNKLKTYSFPGDKDGVKTRRNSSICPRKPNAVSPLRVESNELSSHSHSRSLSHELTKPSGRRKSYHRKSHAISFSRSCKPNFIDGYDSNSSIGVNSRKTSLASSFLDKEYHSSPDTSYTHQMSPKNTIMNTNEQLRRNASGRFGSLKEFAEKNQINIEGKIFAHKVETGDILQPLIDLDIDNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	QKERERISTFSFPTT HHHHHCCEEEECCCC	29.62	22369663
14	Phosphorylation	KERERISTFSFPTTG HHHHCCEEEECCCCC	22.41	22369663
16	Phosphorylation	RERISTFSFPTTGSQ HHCCEEEECCCCCCC	30.33	22369663
19	Phosphorylation	ISTFSFPTTGSQSST CEEEECCCCCCCCCC	41.60	22369663
20	Phosphorylation	STFSFPTTGSQSSTS EEEECCCCCCCCCCC	34.76	22369663
22	Phosphorylation	FSFPTTGSQSSTSIK EECCCCCCCCCCCHH	25.46	22369663
24	Phosphorylation	FPTTGSQSSTSIKSL CCCCCCCCCCCHHHC	36.96	22369663
25	Phosphorylation	PTTGSQSSTSIKSLG CCCCCCCCCCHHHCC	20.66	22369663
26	Phosphorylation	TTGSQSSTSIKSLGS CCCCCCCCCHHHCCC	39.45	22369663
27	Phosphorylation	TGSQSSTSIKSLGSP CCCCCCCCHHHCCCC	29.93	22369663
30	Phosphorylation	QSSTSIKSLGSPLYG CCCCCHHHCCCCCCC	35.97	22369663
33	Phosphorylation	TSIKSLGSPLYGRFS CCHHHCCCCCCCCCC	19.61	22369663
36	Phosphorylation	KSLGSPLYGRFSSLS HHCCCCCCCCCCCCC	15.05	28889911
40	Phosphorylation	SPLYGRFSSLSSTES CCCCCCCCCCCCCCH	29.07	22369663
41	Phosphorylation	PLYGRFSSLSSTESQ CCCCCCCCCCCCCHH	29.56	22369663
43	Phosphorylation	YGRFSSLSSTESQFD CCCCCCCCCCCHHCC	36.84	22369663
44	Phosphorylation	GRFSSLSSTESQFDS CCCCCCCCCCHHCCC	41.30	22369663
45	Phosphorylation	RFSSLSSTESQFDSS CCCCCCCCCHHCCCC	35.96	22369663
47	Phosphorylation	SSLSSTESQFDSSKQ CCCCCCCHHCCCCCC	35.91	22369663
51	Phosphorylation	STESQFDSSKQPHEY CCCHHCCCCCCCCCC	40.50	22369663
52	Phosphorylation	TESQFDSSKQPHEYE CCHHCCCCCCCCCCC	36.83	22369663
58	Phosphorylation	SSKQPHEYEKSFYFE CCCCCCCCCCCCEEE	26.14	22369663
80	Phosphorylation	FNKLKTYSFPGDKDG HHHHCEECCCCCCCC	30.14	30377154
90	Phosphorylation	GDKDGVKTRRNSSIC CCCCCCCCCCCCCCC	32.24	28889911
94	Phosphorylation	GVKTRRNSSICPRKP CCCCCCCCCCCCCCC	21.19	25704821
95	Phosphorylation	VKTRRNSSICPRKPN CCCCCCCCCCCCCCC	31.58	28889911
105	Phosphorylation	PRKPNAVSPLRVESN CCCCCCCCCCEEECC	18.79	28889911
120	Phosphorylation	ELSSHSHSRSLSHEL CCCCCCCCCCCCCCC	26.95	28132839
122	Phosphorylation	SSHSHSRSLSHELTK CCCCCCCCCCCCCCC	36.92	22369663
124	Phosphorylation	HSHSRSLSHELTKPS CCCCCCCCCCCCCCC	19.03	22369663
128	Phosphorylation	RSLSHELTKPSGRRK CCCCCCCCCCCCCCC	37.61	22369663
131	Phosphorylation	SHELTKPSGRRKSYH CCCCCCCCCCCCCHH	46.63	22369663
141	Phosphorylation	RKSYHRKSHAISFSR CCCHHCCHHHHEECC	20.36	24909858
145	Phosphorylation	HRKSHAISFSRSCKP HCCHHHHEECCCCCC	20.25	24909858
147	Phosphorylation	KSHAISFSRSCKPNF CHHHHEECCCCCCCC	19.25	28889911
160	Phosphorylation	NFIDGYDSNSSIGVN CCCCCCCCCCCCCCC	30.08	28889911
163	Phosphorylation	DGYDSNSSIGVNSRK CCCCCCCCCCCCCCC	27.84	24961812
168	Phosphorylation	NSSIGVNSRKTSLAS CCCCCCCCCCCHHHH	32.52	28889911
171	Phosphorylation	IGVNSRKTSLASSFL CCCCCCCCHHHHHHH	28.06	22890988
172	Phosphorylation	GVNSRKTSLASSFLD CCCCCCCHHHHHHHC	25.60	22890988
175	Phosphorylation	SRKTSLASSFLDKEY CCCCHHHHHHHCCCC	27.24	22890988
176	Phosphorylation	RKTSLASSFLDKEYH CCCHHHHHHHCCCCC	24.99	22890988
182	Phosphorylation	SSFLDKEYHSSPDTS HHHHCCCCCCCCCCC	16.85	21440633
184	Phosphorylation	FLDKEYHSSPDTSYT HHCCCCCCCCCCCCC	42.54	22369663
185	Phosphorylation	LDKEYHSSPDTSYTH HCCCCCCCCCCCCCC	17.30	22369663
188	Phosphorylation	EYHSSPDTSYTHQMS CCCCCCCCCCCCCCC	27.32	22369663
189	Phosphorylation	YHSSPDTSYTHQMSP CCCCCCCCCCCCCCC	35.10	22369663
190	Phosphorylation	HSSPDTSYTHQMSPK CCCCCCCCCCCCCCC	15.44	22369663
191	Phosphorylation	SSPDTSYTHQMSPKN CCCCCCCCCCCCCCC	12.85	21440633
195	Phosphorylation	TSYTHQMSPKNTIMN CCCCCCCCCCCCCCC	26.59	21440633
203	Phosphorylation	PKNTIMNTNEQLRRN CCCCCCCHHHHHHHH	23.81	24961812
212	Phosphorylation	EQLRRNASGRFGSLK HHHHHHCCCCCCCHH	33.77	24961812
217	Phosphorylation	NASGRFGSLKEFAEK HCCCCCCCHHHHHHH	33.29	15665377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICS2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICS2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICS2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YFF2_YEAST	YFL052W	genetic	27708008
YGZ2_YEAST	YGL242C	genetic	27708008
STF2_YEAST	STF2	genetic	27708008
FRE8_YEAST	FRE8	genetic	27708008
POC1_YEAST	PBA1	genetic	27708008
RL6B_YEAST	RPL6B	genetic	27708008
YMK8_YEAST	YML108W	genetic	27708008
MSB4_YEAST	MSB4	genetic	27708008
BUB3_YEAST	BUB3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, AND MASSSPECTROMETRY.
PubMed: 18407956